Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Wellcome Trust and MRC Invest £13m to Create a New National Stem Cell Resource

Published: Wednesday, November 07, 2012
Last Updated: Wednesday, November 07, 2012
Bookmark and Share
The Wellcome Trust and Medical Research Council today announced a £12.75 million initiative to create a catalogue of high-quality adult stem cells (iPS cells).

The initiative will provide a knowledge base to underpin the use of such cells in studying the effects of our genes on health and disease and lay the foundations to create a new iPS cell bank, providing a world-class resource for UK researchers.

The investment will enable researchers to exploit the technology made possible by the discoveries of Professor Sir John Gurdon and Professor Shinya Yamanaka, who this year received a Nobel Prize for their pioneering research into changing adult cells into stem cells.

Induced pluripotent stem (iPS) cells are derived from ordinary cells of the adult body by winding the clock back and reprogramming them to become stem cells. They have the potential to develop into a wide range of specialised cell types and are particularly useful for studying the biological mechanisms of disease and exploring the impact of genetic variation on cell behaviour.

The Human Induced Pluripotent Stem Cell Initiative will generate iPS cells from healthy volunteers and patient groups. Using state-of-the-art techniques, researchers will conduct extensive genetic analysis on the cells and will characterise how the cells respond to specific external stimuli and develop into specialised cell types.

The resulting cell collection and dataset will be the UK's most comprehensive resource for investigating how genetic variation impacts cell behaviour and how diseases linked to a specific genetic defect can result in a broad spectrum of clinical abnormalities. The project will be led by King's College London and the Wellcome Trust Sanger Institute.

Professor Fiona Watt of Kings College London said: "The Human Induced Pluripotent Stem Cell Initiative brings together world-leading expertise in clinical genetics, stem cell biology and genomic technologies. We believe that this research will drive forward the translation of basic research into improved diagnosis and treatment of disease.

"At King's, we also hope this will enable us to open a 'Stem Cell Hotel', providing a platform for collaborative experiments between clinician scientists with in-depth knowledge of specific diseases and cell biologists who have the tools to obtain quantitative readouts of cell behaviour."

"Since the Human Genome Project, we have been working to uncover the role of variation in our genome for our wellbeing," explains Dr Richard Durbin, from the Wellcome Trust Sanger Institute. "The 1000 Genomes Project published its first comprehensive suite of findings last Wednesday: today's announcement will harness biological research on a similarly powerful scale to give that variation biological meaning. By tying genetic variation to changes in the behaviour of human cells, we will build paths to understanding human disease."

Sanger Institute investigators aim to make more than 1000 iPS cell lines from healthy people and those with disease, and will use genomic approaches to study variation in their cellular function. The multi-institution project will include collaborations with the University of Cambridge, University of Dundee, European Bioinformatics Institute and UCL (University College London).

"The Human Induced Pluripotent Stem Cell Initiative will be an important resource that will help researchers around the world understand the links between genetic variation, cell behaviour and disease and speed up the translation of this research into improved diagnosis and treatment of disease," said Sir Mark Walport, director of the Wellcome Trust.

"The field of induced pluripotent stem cell research was made possible thanks to the seminal discoveries of Sir John Gurdon and Shinya Yamanaka, who were last month awarded the Nobel Prize for Medicine or Physiology for their work. This is a field in which the UK remains at the cutting edge. Our investment in this new initiative should further strengthen the UK's position and lead to patient benefit."

Professor Sir John Savill, Chief Executive of the MRC, said: "Induced pluripotent stem cells hold enormous potential to help us understand and treat human disease, but currently the application of iPS cell technology is limited by gaps in our knowledge regarding their biological properties and how we can best manipulate them to accurately model human disease.

"By investing in a UK-wide initiative in iPS cell technology, we hope to propel UK researchers to the forefront of this rapidly evolving field and provide an invaluable stock of high-quality cell lines for use by academia and industry alike."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More Than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Hand-Held Nanopore Tech Sequences Multiple Human Genomes
Wellcome Trust Centre for Human Genetics, Genomics plc have been first to sequence multiple human genomes using hand-held nanopore technology.
Monday, December 05, 2016
Five New Breast Cancer Genes Found
Discovery of mutations paves the way for personalised treatment of breast cancer.
Tuesday, May 03, 2016
How Black Fever Beats Drugs
For drug resistance, sometimes it just takes two (extra DNA base pairs).
Wednesday, March 23, 2016
Gene Expression: A Snapshot of Stem Cell Development
New genes found that regulate development of stem cells.
Monday, October 05, 2015
New Research will Show How the Environment Could Change the Way We Eat
A new study funded by the Wellcome Trust will investigate how environmental changes over the next 20-30 years may impact the way we eat, in the UK and worldwide.
Thursday, July 16, 2015
Single Cells Seen In Unprecedented Detail
Parallel sequencing of DNA and RNA provides insight into secret world of cells.
Wednesday, April 29, 2015
The First Fine-Scale Genetic Map Of The British Isles
Many people in the UK feel a strong sense of regional identity, and it now appears that there may be a scientific basis to this feeling, according to a landmark new study into the genetic makeup of the British Isles.
Thursday, March 19, 2015
Project to Focus on Link Between Immune System and Brain Disorders
Researchers to investigate whether mood disorders, such as depression, and neurodegenerative diseases, such as Alzheimer’s, could be treated by targeting the immune system.
Monday, December 22, 2014
Ability Of HIV To Cause AIDS Could Be Slowing
Research indicates that HIV is becoming less virulent.
Tuesday, December 02, 2014
£5m Programme to Investigate Brain Networks
The studies in primates will look at how networks of millions of neurons in the brain give rise to key functions.
Friday, May 16, 2014
Lonely Bacteria are More Likely to Become Antibiotic-resistant
Scientists from the University of Manchester have discovered that microbes in smaller groups are more likely to mutate, resulting in higher rates of antibiotic resistance.
Wednesday, April 30, 2014
Faster Visa Endorsement will Support International Mobility for Top Researchers
This visa route is designed for the brightest and best bringing them from outside the European Economic Area to the UK.
Monday, April 07, 2014
Stem Cell Transplant Repairs Damaged Gut in Mouse Model of IBD
The findings pave the way for patient-specific regenerative therapies for inflammatory bowel diseases such as ulcerative colitis.
Friday, October 18, 2013
New Foot-and-Mouth Vaccine Signals Huge Advance in Global Disease Control
New FMDV vaccine designed to trigger optimum immune response.
Friday, March 29, 2013
Data from Historic Phase IIb Clinical Trial for Tuberculosis Vaccine Candidate Published
Vaccine candidate did not provide statistically-significant protection in preventing TB disease in infants previously vaccinated with BCG.
Monday, February 04, 2013
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Diabetes Missing Link Discovered
Researchers from the University of Auckland have shown that beta catenin plays a vital role in the control of insulin release from the pancreas.
Study Reveals New Role for Hippo Pathway in Suppressing Cancer Immunity
Hippo pathway signaling regulates organ size by moderating cell growth, apoptosis and stem cell renewal, but dysregulation contributes to cancer development.
Biological Link between the Gut Microbiome and Parkinson’s Disease
The findings suggest that targeting the gut microbiome may provide a new approach for diagnosing and treating Parkinson’s disease.
How the Brain Recognizes Faces
Machine-learning system spontaneously reproduces aspects of human neurology.
Boosting Effectiveness of Asthma Therapy
A team of scientists from UCSF has developed a new treatment to dampen bronchospasm.
Improved Stability, Shelf Life of Protein Drugs
Study improves protein drug stability and extend their shelf life by tested a novel route for non-covalent protein modification.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!