Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Nanoparticle Tracking Analysis Technology Facilitates Cancer Metastasis Research

Published: Tuesday, November 13, 2012
Last Updated: Tuesday, November 13, 2012
Bookmark and Share
NanoSight reports on the breakthrough cancer metastasis research of Dr. Hector Peinado Selgas and Dr. David Lyden's research team from Weill Cornell Medical College.

Lead study author Dr. Peinado, Instructor of Molecular Biology in the Department of Pediatrics at Weill Cornell, describes in his recent published research work in Nature Medicine* with senior author Dr. Lyden's research group how they were able to gain better understanding and characterization of exosomes, secreted nanoparticles from tumor cells.

"In our laboratory, we are interested in analyzing the role of tumor-secreted exosomes in metastasis. We have recently published a study describing how exosomes secreted from melanoma tumor cells are educating bone marrow derived progenitor cells toward a pro-metastatic phenotype. We are also interested in analyzing the use of exosomes as biomarkers of specific tumor types and their use as prognostic factors, on which Cornell University currently has pending patents on this technology."

"We have found that the protein content per exosome is increased in metastatic melanoma patients. In addition, we have observed that metastatic cell lines also have increased protein content per exosome. Therefore, knowing the number of exosomes was a definitive and necessary step in our reseach. Before this work, we were only following qualitative changes in exosomes. Now we are able to make quantitative analyses using Nanoparticle Tracking Analysis technology. This has faciliated our recent research work."

"Prior to using NTA, I was measuring exosome size by electron microscopy. There was no other technique available. The new technology allows us to analyze millions of particles, particle by particle, in minutes giving not only numbers but also population distribution. Although the measurement of the size of the particles is not as accurate as the electron microscopy, NTA does allow us to process a large number of samples in a short time period."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Studying behaviour of Exosomes and Microvesicles using Nanoparticle Tracking Analysis
Dr Gregory Gores of the Mayo Clinic in Rochester, Minnesota is using NTA to study extracellular vesicles.
Tuesday, November 19, 2013
NanoSight Acquired by Malvern Instruments
The acquisition of NanoSight by Malvern Instruments was completed on Friday 27 September.
Monday, September 30, 2013
NanoSight Wins a 2013 Queen's Award for Enterprise – Innovation
Award follows on from their 2012 Queen's Award for Enterprise for International Trade.
Monday, April 22, 2013
Conference Highlights Biomarker Detection Role for NanoSight
Oxford researchers presented new data applying NTA to size and count both cellular microvesicles and exosomes at a low concentration.
Saturday, October 09, 2010
The Forschungszentrum Dresden-Rossendorf Chooses NanoSight to Characterize Magnetic Nanoparticles
NanoSight’s LM-20 nanoparticle characterization system to study magnetic nanoparticles for applications in cancer therapy.
Wednesday, August 18, 2010
NanoSight Holds First European Users Meeting on Nanoparticle Characterization in Langen, Germany
Meeting provided an excellent opportunity to present new data using nanoparticle tracking analysis, NTA.
Thursday, July 15, 2010
NanoSight holds first European users meeting on nanoparticle characterization in Langen, Germany
NanoSight, world-leading manufacturers of unique nanoparticle characterization technology, together with distributor partners Schaefer Technologie, have recently held a meeting of users of their successful range of nanoparticle tracking analysis instruments in Langen, Germany.
Tuesday, July 13, 2010
University of Leicester Uses NanoSight to Characterize Marine Viruses and Bacteriophages
Microbiologists use NanoSight system to study cyanobacteria and their viruses which involves the accurate enumeration of viral particles.
Wednesday, June 09, 2010
Leiden University uses NanoSight Characterization System to Aid their Drug Delivery Research Programs
NanoSight helps the research group to focus on vaccine delivery and on protein formulation and characterization with respect to immunogenicity.
Wednesday, February 24, 2010
Strathclyde’s Nanometrology Centre Selects NanoSight to Develop New Biosensors
University of Strathclyde has selected an LM-10 characterization system to aid in their research and development of new biosensors.
Wednesday, November 11, 2009
NanoSight to Supply Instrumentation for Wellcome Trust Technology Development Grant
NanoSight’s methodologies aimed at measuring cellular nanoparticles in plasma and urine as biomarkers of a broad range of human disease conditions.
Friday, May 22, 2009
NanoSight Nanoparticle Detection Technique Contributes to Virus Production to Counter MRSA
Researchers at the University of Strathclyde use virus particle detection and counting using Nanoparticle Tracking Analysis to combat MRSA.
Tuesday, December 09, 2008
NanoSight Receives £925,000 in Funding Round to Expand their Nanoparticle Characterization Business
The new round of financing which will enable the company to expand the business with the development of new products and sales channels in the US market.
Thursday, November 06, 2008
Nanosight Angel Investor Round
The angel investor round increases its shareholder base and complements previous investments by Venture Capital companies.
Monday, September 10, 2007
NanoSight Raises £250k in Second Tranche of Fundraising
The investment supports Company’s current sales drive and develops capabilities in nanoparticle analysis.
Wednesday, September 27, 2006
Scientific News
13 Ways to Stop an Unseen Force from Disrupting Weighing
Download a free Mettler Toledo paper to discover how to halt static’s negative effects before the next weigh-in.
Flinders Ig Nobel Winner Cracks Global Anaesthetic
One of the world’s most in-demand anaesthetics can now be produced on the spot, thanks to the thermos-flask sized device that recently won Flinders University inventor Professor Colin Raston an Ig Nobel prize.
Resurrected Proteins Double Their Natural Activity
Researchers demonstrate method for reviving denatured proteins.
Genes That Protect African Children From Developing Malaria Identified
Variations in DNA at a specific location on the genome that protect African children from developing severe malaria, in some cases nearly halving a child’s chance of developing the life-threatening disease, have been identified in the largest genetic association study of malaria to date.
Messing With The Monsoon
Manmade aerosols can alter rainfall in the world’s most populous region.
Potential Target for Treatment of Autism
Grant of $2.4 million will support further research.
Scientists Decode Structure at Root of Muscular Disease
Researchers at Rice University and Baylor College of Medicine have unlocked the structural details of a protein seen as key to treating a neuromuscular disease.
Sniffing Out Cancer
Scientists have been exploring new ways to “smell” signs of cancer by analyzing what’s in patients’ breath.
New Test Detects All Viruses
A new test detects virtually any virus that infects people and animals, according to research at Washington University School of Medicine in St. Louis, where the technology was developed.
Inroads Against Leukemia
Potential for halting disease in molecule isolated from sea sponges.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos