Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Crown Bioscience, Inc. and Horizon Discovery, Ltd. to Showcase X-MAN Cell Lines

Published: Thursday, November 15, 2012
Last Updated: Thursday, November 15, 2012
Bookmark and Share
Companies will highlight the availability of X-MAN™ cell lines for in vitro and in vivo drug discovery model validation at the 24th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics.

High-quality human disease models are crucial for generating 'first-in-class' patient-relevant targets and facilitating the development of novel oncology targets and early-stage drug discovery programs within the pharmaceutical industry. The new in vivo X-MAN (X-Gene Mutant And Normal) models will be made available to customers by Crown Bioscience via a new service offering whilst Horizon will provide access to a broad range of in vitro services based around its inventory of; >450 X-MAN cell lines, >50 phenotypic cell-based assays and its SyntheTx™ drug/RNAi screening platform.

Leveraging their unique drug discovery and translational research platforms, Crown Bioscience and Horizon Discovery help develop the best drug candidates with high confidence for clinical development, reducing drug attrition and development cost. Crown Bioscience and Horizon Discovery are ideally placed to help bring to the clinic lead molecules based upon highly validated and novel drug models. The in vitro and in vivo cell lines are available to clients who want to help validate new models and become early adopters with full access to new models at the earliest possible phase.

“Crown Bioscience aspires to become the innovation engine for the global biotech and pharmaceutical industry. We are guided by our responsibility to clients and a desire to make a major positive impact on human life worldwide. We are constantly pioneering new paths and finding new answers to meet the urgent needs of our customers’ waging war against cancer,” said Jean-Pierre Wery, President of Crown Bioscience. “The novel in vivo models we are developing based on the X-MANTM cell lines offer new opportunities for clients to collaborate with us at an early stage and validate the models based on their needs, This will allow greater insights and better means to evaluate the therapeutic efficacy of compounds and their impact on key physiological functions.”

“Horizon Discovery uses its highly efficient and proprietary gene-engineering platform technology, GENESIS™ to precisely engineer X-MAN human disease models that harbor the key genetic features that drive a patient’s disease” commented Darrin Disley, CEO of Horizon Discovery. “We are delighted to provide Crown Bioscience with our unique range of X-MAN cell lines, so that Crown can develop and provide our clients with a suite of in vivo models that complements our extensive range of in vitro services.”

The new in vivo models demonstrate Crown Bioscience’s commitment to continuing to invest in and expand its portfolio of models and to work collaboratively with partners and clients to accurately and robustly evaluate the efficacy of new therapeutic agents. The in vivo models are designed to help clients address their key needs and challenges by providing cutting-edge clinically relevant models that are ready to run. Crown Bioscience’s comprehensive services for drug development, from target to pre-IND, have accelerated confident Go/No Go decisions during early stage drug discovery and ensured robust pre-clinical candidate selection.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Genetic Defences of Bacteria Don’t Aid Antibiotic Resistance
Genetic responses to the stresses caused by antibiotics don’t help bacteria to evolve a resistance to the medications, according to a new study by Oxford University researchers.
Detecting HIV Diagnostic Antibodies with DNA Nanomachines
New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and auto-immune diseases such as rheumatoid arthritis and HIV.
Snapshot Turns T Cell Immunology on its Head
New research may have implications for 1 diabetes sufferers.
Tolerant Immune System Increases Cancer Risk
Researchers have found that individuals with high immunoCRIT ratios may have an increased risk of developing certain cancers.
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
New Approach to Treating Heparin-induced Blood Disorder
A potential treatment for a serious clotting condition that can strike patients who receive heparin to treat or prevent blood clots may lie within reach by elucidating the structure of the protein complex at its root.
Horse Illness Shares Signs of Human Disease
Horses with a rare nerve condition have similar signs of disease as people with conditions such as Alzheimer’s, a study has found.
How a Molecular Motor Untangles Protein
Diseases such as Alzheimer’s, Parkinson’s and prion diseases, all involve “tangled” proteins.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos