Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Cerilliant Offers New Certified Spiking Solutions®

Published: Thursday, November 29, 2012
Last Updated: Thursday, November 29, 2012
Bookmark and Share
Preparation of calibrators and controls in nicotine testing and other clinical or diagnostic applications by LC/MS or GC/MS.

Cerilliant has introduced new Certified Spiking Solutions® of nicotine metabolites norcotinine and trans-3-hydroxycotinine as well as nicotine nitrosamines NNN, NNK, and NAB at concentrations of 1.0 mg/mL in methanol for each solution standard.

These certified reference solutions can be used as Snap-N-Spike® starting materials in the laboratory’s matrix of choice for preparation of calibrators and controls in nicotine testing and other clinical or diagnostic applications by LC/MS or GC/MS.

Nicotine biomarkers are commonly monitored in patients who smoke cigarettes, use other nicotine products such as nicotine gum and electronic cigarettes, or are exposed to environmental tobacco smoke.

Accurate patient results in clinical and diagnostic testing of nicotine use depend on accurate and consistent Certified Reference Materials for the numerous nicotine metabolites.

Neat material handling of nicotine analogs and their preparation as certified reference solutions offer significant challenges to the laboratory due to high toxicity of the neat materials and their sensitivity to air and light.

Cerilliant’s validated process includes manufacturing controls for sensitive compounds such as raw material handling and solution preparation under inert conditions and flame-sealing of ampoules under argon to minimize degradation and promote long-term shelf life.

Toxic materials are handled in isolation chambers and are gravimetrically prepared using precision balances which have been qualified to ensure minimal uncertainty.

“Protection of both production staff and the correct handling of these highly toxic neat materials are of paramount importance in the preparation of these solution standards. Consequently the formulation of the nicotine metabolites is limited to staff who have received and passed the appropriated level of internal training through our proficiency testing program to ensure proper use of equipment and accurate preparation using the glove boxes,” added Gregory Kirkovits, PhD, manager of the Standards & Packaging group.

Cerilliant’s latest nicotine metabolite and nitrosamine products complement their current offering of Certified Spiking Solutions® for nicotine, including anabasine, cotinine, and nornicotine and their internal standards, all offered at concentrations suitable for dilution to working levels in the laboratory’s matrix of choice.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Genetic Cause of Rare Allergy
Institute has identified a genetic mutation responsible for a rare form of inherited hives induced by vibratory urticaria.
Battery Component Found to Harm Key Soil Microorganism
The material at the heart of the lithium ion batteries that power electric vehicles, laptop computers and smartphones has been shown to impair a key soil bacterium, according to new research.
Keeping Tumor Growth at Bay
Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets.
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Validating the Accuracy of CRISPR-Cas9
IBS Researchers create multiplex Digenome-seq to find errors in CRISPR-Cas9 processes.
Cancer Drug Target Visualized at Atomic Resolution
New study using cryo-electron microscopy shows how potential drugs could inhibit cancer.
Genetic Mechanism Behind Cancer-Causing Mutations
Researchers at Indiana University has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!