Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

UK Researchers use Nanoscale Thermal Analysis Techniques to Improve Drug Delivery Systems

Published: Tuesday, December 04, 2012
Last Updated: Tuesday, December 04, 2012
Bookmark and Share
Anasys Instruments report on the use of their award-winning nanoscale characterization instrumentation to advance developments in the understanding of drug delivery systems.

The Drug Delivery & Materials Characterization Group at the University of East Anglia, UK, is internationally recognized for work involving the development of novel thermal, dielectric, rheological and microscopic techniques as analytical tools within the pharmaceutical sciences. There is particular emphasis on the study of the physical properties of drugs and dosage forms in relation to performance.

Post-doctoral researcher, Jonathan Moffat, is focused on delivery of poorly water soluble drugs and in particular characterization of delivery systems. His team creates solid dispersions using a variety of different methods which include hot melt extrusion, spray drying and spin coating. Solid dispersions are systems where one or more components are molecularly dispersed in a matrix/carrier. This idea means that if you are able to disperse your drug in a water soluble matrix such as a polymer, then you can improve the dissolution profile and improve the bioavailability of the drug.

The standard characterization methods for these systems include DSC, FTIR and PXRD. Their drawback is that they only provide bulk information. Dr Moffat comments: "As we are analyzing samples consisting of two or more components, we are interested in looking at the distribution, form and at the interface of components. These standard techniques cannot provide this information. Also, the surface of these systems is extremely important as this is the interface between the delivery system and the body. We chose the Anasys nano-TA system as it permits a thorough surface characterization. It is used alongside standard AFM & SEM imaging methods."

Dr Moffat continues: "Whilst these methods can provide high resolution images of the surface of our samples, they cannot provide information on the components within the system. Using nanoTA along with AFM allows the user to pick out features on the surface, interrogate them and subsequently determine the individual component via its transition temperature. As well as determining the component, it is also possible to determine its morphological properties as the transition temperature is sensitive to differences in these properties. This is something that can be difficult to determine with spectroscopic techniques. We also use Transition Temperature Microscopy, TTM, for our samples. This gives a systematic approach to determine the distribution and form of the components and also provides information on how well mixed the systems and whether there is any phase separation."

An example of this work was presented in a poster at the recent AAPS meeting held in Chicago. Dr Moffat's poster presented with co-author, Professor Duncan Craig from UEA, was entitled "Thermal Probe Methods for Nanoscale Characterization of Cyclosporin A Solid Dispersions Prepared by Hot Melt Extrusion."

Kevin Kjoller, Anasys' co-founder and Vice President, says "We're very excited about this new work by Dr Moffat and Professor Craig which potentially opens up a new market for our nanoscale thermal analysis technology." For more details, visit www.anasysinstruments.com/application/nanota-app/.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Researchers Study Cultural Heritage Painting Cross-Sections
Study of cultural heritage painting cross-sections using AFM-based nanoscale mass spectrometry technique.
Friday, January 16, 2015
New NIST AFM-IR Publication has Catalysis Research Implications
Anasys Instruments reports on a new publication from their nanoIR users at NIST which assess the chemical composition of a metal-organic framework with nanoscale resolution.
Tuesday, March 25, 2014
Inventor of AFM-IR Technique to Receive Ernst Abbe Memorial Award
Professor Alexandre Dazzi to receive the award for pioneering field of nanoscale IR Spectroscopy.
Wednesday, March 19, 2014
French Researchers to Identify Best Microbes for Biofuel Production
Scientists used atomic force microscopy combined with infrared spectroscopy.
Wednesday, February 19, 2014
Anasys' NIST Users Report on New AFM-IR Nanoscale Chemical Imaging Method
New application for AFM-IR to study in NIST publication "Tech Beat."
Thursday, July 25, 2013
Purdue University Researchers Use Nanoscale IR Spectroscopy via AFM-IR
Utilizing this technique has provided key insights into drug-polymer blends.
Friday, May 11, 2012
Invited Award Symposium Presentation Nanoscale IR Spectroscopy at Pittcon 2012
Anasys Instruments announced that Dr. Bruce Chase is presenting an invited talk entitled "Structure and Orientation in Electrospun Nanofibers", as part of the Organized Contributed Session on Analytical Applications of Broadly Tunable Lasers.
Thursday, March 08, 2012
Anasys Instruments Receives Microscopy Today’s 2011 Innovation Award
AFM-IR system has been recognized by Microscopy Today in the receipt of the 2011 Innovation Award.
Thursday, August 18, 2011
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!