Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researcher Part of International Pig Genome Sequencing

Published: Friday, December 07, 2012
Last Updated: Friday, December 07, 2012
Bookmark and Share
An animal scientist in Penn State's College of Agricultural Sciences played a role in the first complete sequencing of the pig genome by an international team of researchers.

The study, conducted by the International Swine Genome Sequencing Consortium, provides a genetic comparison of the domesticated pig and its wild cousins.

The research, described in the cover article of the Nov. 15 issue of the journal Nature, offers clues about how the animal evolved. The article is available at http://psu.ag/SHjXHu.

Wansheng Liu, associate professor of animal genomics in the Department of Animal Science, participated in the study, which includes comparisons of the human, mouse, dog, horse, cow and pig genomes.

Funded mostly by the U.S. Department of Agriculture and the National Pork Board, the study promises to expand the usefulness of the pig model in human health and biomedical research, according to Liu.

"The project found variants in 112 genes in the pig genome that were identical to variants implicated in human diseases, including aberrations associated with obesity, diabetes, dyslexia, Parkinson's disease and Alzheimer's disease," he said.

"The sequencing of the pig genome represents a remarkable international initiative involving many universities and research centers worldwide."

Liu and his team at Penn State were involved in the construction of a high-resolution gene map with about 10,000 DNA markers. This map serves as a "scaffold" for pig genome sequence assembly and gene annotation, he noted.

The genome of the common farm pig was compared to the genetic makeup of 10 wild boars from locations in Europe and Asia. The genetic evidence found that the pig emerged in Southeast Asia and expanded into Europe before starting to become domesticated about 10,000 years ago.

"This project is a milestone in a long process that started with man's domestication of the pig to produce food," Liu said. "It offers new opportunities for animal geneticists to understand what genes do and what traits of economic importance they control to improve food production."

The comparison with other mammals' genomes found a rapid evolution of genes in the pig associated with immune response and the sense of smell. Pigs and rats have the greatest number of functional olfactory receptor genes possessed by any species, reflecting the importance of smell in a scavenging animal.

"The pig genome sequence provided us the tools to demonstrate that genes in the pig immune system are more similar to those in the human, in comparison with the genes found in the cow or mouse genomes," Liu explained.

"Researchers now have a genetic blueprint with which to integrate information on nutrition, reproduction, meat science, growth and development, and basic biology, which will benefit both production agriculture and biomedical research," he said.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

3D Printing Cartilage
3D bioprinting has successfully manufactured cartilage using bioink sourced from cow cartilage strands.
Wednesday, July 13, 2016
Genetic Risk Factors of Disparate Diseases Share Similar Biological Underpinnings
Penn Institute for Biomedical Informatics and colleagues identify "roadmap" of disease mechanisms to identify candidate drug targets.
Tuesday, May 03, 2016
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
Friday, April 29, 2016
"Beiging" White Fat Cells to Fight Diabetes
Penn Study reveals a signaling pathway required for beige fat formation.
Wednesday, February 17, 2016
"Gene Fusion" Drives Childhood Brain Cancers
Study co-led by Penn scientists highlights potential targets for future cancer therapies.
Thursday, February 04, 2016
Enzyme Links Age-Related Inflammation, Cancer
Researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration.
Thursday, February 04, 2016
How to Unlock Inaccessible Genes
An international team of biologists has discovered how specialized enzymes remodel the extremely condensed genetic material in the nucleus of cells in order to control which genes can be used.
Thursday, February 04, 2016
Viral Gene Editing System Corrects Genetic Liver Disease
Penn study has implications for developing safe therapies for an array of rare diseases via new gene cut-and-paste methods.
Wednesday, February 03, 2016
Finding the Needle in a Microbial Haystack
After developing a novel investigational technology called PathoChip that can rapidly identify elusive microorganisms, a team of Penn Medicine researchers recently succeeded for the first time in identifying a pathogen in a patient sample, demonstrating the proof of principle that this technology can be used to identify pathogens in human disease.
Tuesday, January 19, 2016
A Cheap, Disposable Device for Diagnosing Disease
The development of a reusable microfluidic device for sorting and manipulating cells and other micro/nano meter scale objects will make biomedical diagnosis of diseases cheaper and more convenient.
Wednesday, December 09, 2015
Lung Repair and Regeneration Gene Discovered
New role for hedgehog gene offers better understanding of lung disease.
Wednesday, October 07, 2015
How Blood Cancers Develop
Team urges consideration of cutting-and-pasting errors when using enzymes for gene modification.
Monday, September 14, 2015
Targeting HIV in Semen to Shut Down AIDS
Breaking up amyloid fibrils in semen makes cells less likely to be infected, Penn pre-clinical study finds.
Wednesday, August 19, 2015
Study Details ‘Rotten Egg’ Gas’ Role in Autoimmune Disease
The finding unveils several new possible points for therapeutic intervention, with implications for autoimmune diseases as well as other conditions such as cancer and hypertension.
Monday, August 17, 2015
Protein That Turns Moles Into Melanoma Cancer Identified
Moles can turn into cancer, if the genetic factors recently identified by a team of researchers at the University of Pennsylvania were not present in humans.
Wednesday, August 12, 2015
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Connectome Map More Than Doubles Human Cortex’s Known Regions
Researchers at NIH have developed software that automatically detects the “fingerprint” of each of these areas in an individual’s brain scans.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
Human Stem Cells to Rapidly Generate Bone, Heart Muscle
A new study shows that combining positive and negative signals can quickly and efficiently steer stem cells down complex developmental pathways to become specialized tissues that could be used in the clinic.
New Mechanism of Tuberculosis Infection
Researchers at UTSW Medical Center have identified a new way that tuberculosis bacteria get into the body, revealing a potential therapeutic angle to explore.
New Therapeutic Targets For Small Cell Lung Cancer Identified
Researchers at UTSW Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer and that, when deleted in the lungs of mice, prevents the cancer from forming.
Eliminating Doubt in Criminal Investigations
New ASU certificate to help curb error, misunderstanding in the quest for justice.
Determination of 13 Organic Toxicants in Human Blood
Researchers have utilised liquid-liquid extraction coupling HPLC-MS/MS to identify and quantify organic toxicants in human blood.
A Novel Cell Culture Model For Forensic Biology Experiments
Researchers have developed a new cell culture model which provides an efficient research tool in forensic biology.
Rhino DNA Bank Aids Anti-Poaching Fight
At the University of Pretoria's Veterinary Genetics Laboratory (VGL) at Onderstepoort, Dr Cindy Harper and her team have developed a ground-breaking technique to collect and catalogue DNA from rhinos and rhino horns.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!