Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

A Second Ascent of Chemistry’s Mt. Everest

Published: Tuesday, December 18, 2012
Last Updated: Tuesday, December 18, 2012
Bookmark and Share
Synthetic chemistry meets drug discovery with the synthesis of rare substance.

In science’s equivalent of ascending Mt. Everest, researchers are reporting success in one of the most difficult challenges in synthetic chemistry — a field in which scientists reproduce natural and other substances from jars of chemicals in a lab.

The feat, reported in the Journal of the American Chemical Society, involved synthesis of a rare substance with promising in vitro anti-cancer effects found naturally in tiny amounts in a Chinese medicinal herb.

Samuel J. Danishefsky and Feng Peng explain that maoecrystal V occurs naturally in a plant growing in China’s Yunnan province. Practitioners of Chinese traditional medicine have used the herb, called Isodon eriocalyx Hara, for hundreds of years. Scientists isolated maoecrystal V in 1994 and found that it has anti-cancer effects that warrant further examination. Large amounts would be needed to do so. However, the herb contains only small amounts of the material. In one experiment, it took more than 26 pounds of dried leaves to produce 0.00017637 oz. of maoecrystal V. In 2010, the first group of scientists succeeded in making maoecrystal V in a lab. Now, a second group has found a new route to the potential anti-cancer compound.

Danishefsky and Peng describe their approach as providing the basis for a synthesis that may help scientists develop a practical route to the substance for drug development and other research. It yielded a mixture of the two enantiomeric forms of maoecrystal V. They are pursuing several improvements, including a way to control the reactions to yield only a single enantiomer of the substance.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Detecting Fake Parmesan Cheeses
Scientists report on a way to catch adulteration of the regional artisanal products.
Friday, May 20, 2016
Measuring The Airborne Toxicants Urban Bicyclists Inhale
Researchers analyze breath biomarkers to measure uptake of volatile organic compounds by bicyclists.
Friday, May 06, 2016
Vinegar Could Potentially Help Treat Ulcerative Colitis
Vinegar is the perfect ingredient for making tangy sauces and dressings. Now, researchers report that the popular liquid could also help fight ulcerative colitis, an inflammatory bowel disease that research suggests is related to the gut microbiome.
Monday, February 15, 2016
Sniffing Out Cancer
Scientists have been exploring new ways to “smell” signs of cancer by analyzing what’s in patients’ breath.
Thursday, October 01, 2015
New, Improved Approach To Mammograms
Detecting breast cancer in women with dense mammary tissues could become more reliable with a new mammogram procedure that researchers have now tested in pre-clinical studies of mice.
Friday, September 18, 2015
“Heat” From Chilli Peppers Could Help Kill Cancer Cells
Capsaicin, the compound responsible for chilis’ heat, is used in creams sold to relieve pain, and recent research shows that in high doses, it kills prostate cancer cells.
Friday, September 11, 2015
Preventing Drinking Water Contamination by Pharmaceuticals
In recent years, researchers have realized that many products, including pharmaceuticals, have ended up where they’re not supposed to be — in our drinking water.
Friday, September 11, 2015
Cheap Diagnostics with a Portable "Paper Machine"
Scientists have developed a cheap, portable system for point of care diagnostics for a range of infectious diseases, genetic conditions and cancer.
Monday, July 20, 2015
Microfluidic Device Mixes And Matches DNA For Synthetic Biology
Researchers have developed a microfluidic device that quickly builds packages of DNA and delivers them into bacteria or yeast for further testing.
Monday, July 06, 2015
Artificial Pancreas Controls Diabetes
Scientists are reporting the development of an implantable “artificial pancreas” that continuously measures a person’s blood sugar, or glucose, level and can automatically release insulin as needed.
Friday, July 03, 2015
Expanding the Code of Life With New “Letters”
Researchers have developed a new nucleotide pair that can be added to DNA, raising the possibility that entirely new proteins could be created for medical uses.
Friday, May 29, 2015
Bioresorbable Electronic Stent Could Provide Feedback, Therapy
Researchers have developed and tested a drug releasing electronic stent which could significantly reduce the risk associated with traditional mesh tube stents.
Thursday, May 28, 2015
How Used Coffee-Grounds Could Make Some Food More Healthful
Phenols in coffee ground extracts could be used as additives to enhances other food products.
Thursday, May 14, 2015
Kimchi-based Preservative Used in Cosmetics is Not So Natural
Scientists report that kimchi-based preservative marketed as “all-natural” contains synthetic ingredients.
Friday, April 17, 2015
Novel Nanoparticles Could Save Soldiers’ Lives After Explosions
Researchers paired clot-promoting nanoparticles with a corticosteroid that stops inflammation.
Friday, April 17, 2015
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
World’s Largest Coral Gene Database
‘Genetic toolkit’ will help shed light on which species survive climate change.
A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
Breast Cancer Drug Hope
A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.
Untangling Disease-Related Protein Misfolding
Work advances understanding of genetic forms of thrombosis, emphysema, cirrhosis of the liver, neurodegenerative diseases and inflammation, among others.
Early Genetic Changes in Premalignant Colorectal Tissue Identified
Findings point to drivers of early cancer development, targets for cancer prevention therapies.
Harnessing Nature’s Vast Array of Venoms for Drug Discovery
Scripps scientists have developed a method for rapidly identifying venoms.
Nanoparticles Target, Transform Fat Tissue
Nanoparticles designed to target white fat and convert it to calorie-burning brown fat slowed weight gain in obese mice without affecting food intake. This proof-of-concept work could lead to new therapies to treat obesity.
New Cancer Fighters Emerge From Lab
Rice University lab simplifies total synthesis of anti-cancer agent.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!