Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Protein Strongest Just Before Death

Published: Tuesday, December 18, 2012
Last Updated: Tuesday, December 18, 2012
Bookmark and Share
Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.

The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer.

“Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang Zhang, a lead author and MSU cell and molecular biology graduate student. “This is an unusual way for proteins to act.”

As an organism grows, proteins essential for fueling its prosperity typically toe a tight line, performing their jobs at the right place and time. If these proteins go rogue, disasters such as cancer can result.

Retinoblastoma proteins, which could be labeled as rebellious ¬as opposed to rogue, perform acts of valor rather than destruction. And just like fireworks, they save their best work for the finale.

Proteins’ lifecycles end with degradation, and like most living things they become weaker and less efficient at their jobs near the end of their lives. For Retinoblastoma proteins, however, their destruction is linked to their ability to efficiently control excessive cell growth.

Using the fruit fly Drosophila, MSU researchers isolated the specific region that controls the protein’s ability to degrade. Strikingly, this is the same region the protein uses to hit its stride and exert its full power to suppress genes related to unrestrained cell growth. Other categories of genes, such as those linked to cell death, may not be influenced by this specific region that controls degradation. This sheds light on a single mechanism that controls both living and dying at the genetic level.

Identifying this mechanism in fruit flies could be beneficial to humans. David Arnosti, MSU biochemist and director of MSU’s Gene Expression in Disease Development initiative, noted the genetic similarities between humans and Drosophila, describing fruit flies as “resembling little people with wings.”

“By revealing the molecular details about the regulation of the fly Retinoblastoma protein, we can start to understand the possible roles of the human counterparts in cancer,” he said.

The research was a product of NIH-funded research between the laboratories of Arnosti and R. William Henry, MSU biochemist.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Molecular Map Provides Clues To Zinc-Related Diseases
Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases.
Wednesday, June 22, 2016
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Friday, April 29, 2016
MSU to Lead $6.5 Million Research on Disease Resistance in Cucurbits
A national team of 20 scientists led by Michigan State University has been awarded $6.5 million grant to accelerate the development of disease-resistant cucurbit crops through leveraging applied genomics.
Wednesday, October 07, 2015
Researchers Pioneer Use of Capsules to Save Materials
Wax capsule delivery systems can simplify a wide range of chemistry transformations.
Friday, August 14, 2015
Fingerprint Accuracy Stays The Same Over Time
Researchers have shown that fingerprint recognition accuracy remains stable in subjects apprehended multiple times over a period of 5 to 12 years.
Friday, July 24, 2015
MSU Scientists Uncover a ‘Funky Cofactor’
While examining the chemical reactions of bacterial cells in a lab at Michigan State University, researchers found an unusually complex molecule in a protein that completes a simple process.
Thursday, July 09, 2015
Perennial Biofuel Crops’ Water Consumption Similar to Corn
A recent study looks at how efficiently “second-generation” biofuel crops—perennial, non-food crops such as switchgrass or native grasses—use rainwater and how these crops affect overall water balance.
Wednesday, July 08, 2015
Heartbeat on a Chip Could Improve Pharmaceutical Tests
A gravity-powered chip that can mimic a human heartbeat outside the body could advance pharmaceutical testing and open new possibilities in cell culture because it can mimic fundamental physical rhythms.
Thursday, June 18, 2015
‘Fracture’ Prints, Not Fingerprints, Help Solve Child Abuse Cases
Much like a finger leaves its own unique print to help identify a person, researchers are now discovering that skull fractures leave certain signatures that can help investigators better determine what caused the injury.
Monday, May 11, 2015
A Poisonous Cure
Toxic fungi may hold the secrets to tackling deadly diseases.
Thursday, December 04, 2014
Identifying the Source of Stem Cells
Researchers discover that Sox2 gene could determine the source of stem cells in mammals.
Saturday, November 01, 2014
New, Fossil-fuel-free Process Makes Biodiesel Sustainable
A new fuel-cell concept, developed by a Michigan State University researcher, will allow biodiesel plants to eliminate the creation of hazardous wastes while removing their dependence on fossil fuel from their production process.
Wednesday, May 21, 2014
MSU Leads Largest Soil DNA Sequencing Effort
Study also created a new analytic approach, which makes interpreting the data much easier.
Thursday, March 13, 2014
How Do You Feed 9 Billion People?
An international team of scientists has developed crop models to better forecast food production to feed a growing population in the face of climate change.
Wednesday, June 12, 2013
MSU Researchers Decode Deadly E. coli Strain
Highly virulent strain of E. coli lead to 54 deaths in Germany.
Friday, August 24, 2012
Scientific News
Open Source Seed Initiative – A Welcome Boost to Global Crop Breeding
A team of plant breeders, farmers, non-profit agencies, seed advocates, and policymakers have created the Open Source Seed Initiative.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Implementation Science Approaches to Reduce Mother-to-Child HIV Transmission
The NIH study will investigate best practices to ease major disease burden in Sub-Saharan Africa.
Tough New Hydrogel Hybrid Doesn’t Dry Out
Water-based material could be used to make artificial skin, longer-lasting contact lenses.
New CAR T Cell Therapy Using Double Target Aimed at Solid Tumors
Researchers at Penn University have described how antibody, carbohydrate combination could apply to range of cancer types.
Lasers Carve the Path to Tissue Engineering
A new technique, developed at EPFL, combines microfluidics and lasers to guide cells in 3D space, overcoming major limitations to tissue engineering.
Link Between Canned Food, BPA Exposure Revealed
New Stanford research resolves the debate on the link between canned food and exposure to the hormone-disrupting chemical known as Bisphenol A, or BPA.
Portable Test Rapidly Detects Zika
To better diagnose and track the disease, scientists are now reporting a new $2 test that in the lab can accurately detect low levels of the virus in saliva.
Erasing Unpleasant Memories with a Genetic Switch
Researchers from KU Leuven and the Leibniz Institute for Neurobiology have managed to erase unpleasant memories in mice using a 'genetic switch'.
Unidentified Spectra Detector
New algorithm clusters over 250 million spectra for analysis, such that millions of unidentified peptide sequences can be recognised.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!