Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Moving Towards a Universal Flu Vaccine

Published: Monday, December 31, 2012
Last Updated: Monday, December 31, 2012
Bookmark and Share
Israeli company reports good results with supplemental shot in elderly.

Multimeric-001, an influenza vaccine now in clinical trials, boosts immunity in elderly people when given as a supplement to the seasonal shot.

But supplementation is just a short-term goal: eventually the drug’s maker, BiondVax Pharmaceuticals of Ness Ziona, Israel, believes that Multimeric-001 alone could protect against all strains of flu.

The company will present the results from its second phase II trial of the shot on 3 April at the Second Annual Vaccines Congress in London.

The 90 people aged 65 and older who got the pair of shots, compared to 30 who received only the annual vaccine, mounted a stronger immune response to the three seasonal flu strains, as well as to a few other strains not in the seasonal vaccine.

For most infectious agents, one exposure teaches the body’s immune system to recognize and destroy the virus or bacterium. The standard flu vaccine teaches the body to recognize the virus's outer coating.

But influenza is constantly changing its stripes, mutating from year to year and forcing scientists to guess which three strains to include in the seasonal vaccine.

“This is crazy,” says Vincent Racaniello, a virologist at Columbia University in New York, who is not involved with the Biondvax trials. If there were one vaccine that worked for any kind of flu, no matter how it mutated its coat, the costs of protection would drop and pandemics could disappear, he says.

The Multimeric-001 vaccine comprises nine linked sections from three flu proteins from different parts of the virus. These represent a “common denominator” shared by more than 10,000 flu strains since 1940, says the company’s chief scientist Tamar Ben-Yedidia. Racaniello says that, in theory, this combination or proteins should be universal, because every strain of flu would have them.

In a study published in February in the Journal of Clinical Immunology1, BiondVax reported that its Multimeric-001 vaccine was safe and conferred immunity on its own. However, BiondVax thinks that a universal flu vaccine would be a tough sell to regulatory agencies.

Part of the challenge is that the standard test for a vaccine’s efficacy is based on the presence of antibodies to the ever-changing parts of the haemagglutinin protein on the outside of the virus in a vaccinated person's blood. It’s a test their universal vaccine is designed to fail, because Multimeric-001 does not confer immunity to these proteins.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Blood Pressure Drug May Boost Effectiveness of Lung Cancer Treatment
Researchers at Imperial College London have suggested that the blood pressure drug may make a type of lung cancer treatment more effective.
Insight into Eye Diseases
Scientists recreate zebrafish cell regeneration from retinal stem cells in mice.
New Discovery May Benefit Farmers Worldwide
Scientists have shown how a crop-microbe 'team' protect against fungal infection.
Antibodies Paving the Way to HIV Vaccine
Researchers uncover factors responsible for the formation of broadly neutralizing HIV antibodies in humans.
Designing Drugs with a Whole New Toolbox
Researchers develop methods to design small, targeted proteins with shapes not found in nature.
Protein Studies Discover Molecular Secrets
Two protein studies have mapped proteins that reveal the secrets to recycling carbon and healing cells.
Tapping Evolution to Improve Biotech Products
Researchers show how 'ancestral sequence reconstruction' can be used to guide engineering of a blood clotting protein.
Scroll Up
Scroll Down

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!