Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Japanese Team Creates Cancer-Specific Killer T Cells from iPS Cells

Published: Wednesday, January 09, 2013
Last Updated: Wednesday, January 09, 2013
Bookmark and Share
Researchers have succeeded for the first time in creating cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS cells).

To create these killer cells, the team first had to reprogram T lymphocytes specialized in killing a certain type of cancer, into iPS cells. The iPS cells then generated fully active, cancer-specific T lymphocytes. These lymphocytes regenerated from iPS cells could potentially serve as cancer therapy in the future.

Previous research has shown that killer T lymphocytes produced in the lab using conventional methods are inefficient in killing cancer cells mainly because they have a very short life-span, which limits their use as treatment for cancer. To overcome these problems, the Japanese researchers led by Hiroshi Kawamoto and presenting their results in the journal Cell Stem Cell online today, reprogramed mature human killer T lymphocytes into iPS cells and investigated how these cells differentiate.

The team induced killer T lymphocytes specific for a certain type of skin cancer to reprogram into iPS cells by exposing the lymphocytes to the 'Yamanaka factors'. The 'Yamanaka factors' is a group of compounds that induce cells to revert back to a non-specialized, pluripotent stage. The iPS cells obtained were then grown in the lab and induced to differentiate into killer T lymphocytes again. This new batch of T lymphocytes was shown to be specific for the same type of skin cancer as the original lymphocytes: they maintained the genetic reorganization enabling them to express the cancer-specific receptor on their surface. The new T lymphocytes were also shown to be active and to produce the anti-tumor compound interferon γ.

"We have succeeded in the expansion of antigen-specific T cells by making iPS cells and differentiating them back into functional T cells. The next step will be to test whether these T cells can selectively kill tumor cells but not other cells in the body. If they do, these cells might be directly injected to patients for therapy. This could be realized in the not-so-distant future." explains Dr Kawamoto.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New ACE-inhibiting Molecule Found in the Asparagus
Scientists have determined that sulfur-containing compounds in plants can inhibit ACE.
Saturday, August 22, 2015
The Genetic Roots of Adolescent Scoliosis
Scientists at the RIKEN Center for Integrative Medical Sciences in collaboration with Keio University in Japan have discovered a gene that is linked to susceptibility of Scoliosis.
Thursday, July 30, 2015
Ensuring Food Safety Using Space Technology
New device can detect cesium isotopes in food samples.
Monday, March 09, 2015
Growing Functioning Brain Tissue In 3D
RIKEN researchers have induced human embryonic stem cells to self-organize into a 3D cerebellum like structure.
Monday, February 02, 2015
Insights Into A Rare Genetic Disease
Study shows mutation in NGLY1 gene is linked to a genetic disorder with severe consequences.
Tuesday, January 20, 2015
Predicting Antibiotic Resistance
A common set of features appear to be responsible for the development of resistance to several types of antibiotics.
Friday, December 19, 2014
A Greasy Way to Take Better Protein Snapshots
Researchers used a newly developed grease to suspend small crystals of lysozyme, glucose isomerase, thaumatin, and fatty acid-binding protein type-3.
Wednesday, November 12, 2014
Stress Turns Ordinary Cells Pluripotent
Researchers demonstrate that ordinary somatic cells from newborn mice can be stripped of their differentiation memory, reverting to a state of pluripotency.
Thursday, January 30, 2014
New Fluorescent Protein from Eel Revolutionizes Key Clinical Assay
Unagi, the sea-going Japanese freshwater eel, harbors a fluorescent protein that could serve as the basis for a revolutionary new clinical test.
Friday, June 21, 2013
Gene Identified Responsible for Disorders of Bones and Connective Tissue
Researchers have identified a gene that when mutated is responsible for a spectrum of disorder.
Monday, May 13, 2013
New Metal Hydride Clusters Provide Insights into Hydrogen Storage
The study sheds light on a class of heterometallic molecular structures whose unique features point the way to breakthroughs in the development of lightweight fuel cell technology.
Thursday, September 22, 2011
RIKEN: Genome-wide Study Reveals 3 New Susceptibility Loci for Adult Asthma in Japanese Population
The findings appear in Nature Genetics and derive from a genome-wide study of 4836 Japanese individuals.
Monday, August 01, 2011
Overlooked Peptide Reveals Clues to Causes of Alzheimer's Disease
Highly aggregative and neurotoxic amyloid peptide A-ß-43 points the way to new approaches for AD diagnosis and treatment.
Monday, July 04, 2011
Genetic Variant Linked to Development of Liver Cancer in Hepatitis C Virus Carriers
The research group conduct a genome-wide study to identify risk factors connecting HVC and HCC.
Monday, July 04, 2011
RIKEN: Mechanism for Stress-induced Epigenetic Inheritance Uncovered in New Study
Results highlight the role of the transcription factor dATF-2 in chromatin assembly, marking a major advance in understanding of non-Mendelian inheritance.
Friday, June 24, 2011
Scientific News
13 Ways to Stop an Unseen Force from Disrupting Weighing
Download a free Mettler Toledo paper to discover how to halt static’s negative effects before the next weigh-in.
Flinders Ig Nobel Winner Cracks Global Anaesthetic
One of the world’s most in-demand anaesthetics can now be produced on the spot, thanks to the thermos-flask sized device that recently won Flinders University inventor Professor Colin Raston an Ig Nobel prize.
Resurrected Proteins Double Their Natural Activity
Researchers demonstrate method for reviving denatured proteins.
Genes That Protect African Children From Developing Malaria Identified
Variations in DNA at a specific location on the genome that protect African children from developing severe malaria, in some cases nearly halving a child’s chance of developing the life-threatening disease, have been identified in the largest genetic association study of malaria to date.
Messing With The Monsoon
Manmade aerosols can alter rainfall in the world’s most populous region.
Potential Target for Treatment of Autism
Grant of $2.4 million will support further research.
Scientists Decode Structure at Root of Muscular Disease
Researchers at Rice University and Baylor College of Medicine have unlocked the structural details of a protein seen as key to treating a neuromuscular disease.
Sniffing Out Cancer
Scientists have been exploring new ways to “smell” signs of cancer by analyzing what’s in patients’ breath.
New Test Detects All Viruses
A new test detects virtually any virus that infects people and animals, according to research at Washington University School of Medicine in St. Louis, where the technology was developed.
Inroads Against Leukemia
Potential for halting disease in molecule isolated from sea sponges.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos