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Alcohol ADME in Primates Studied with Positron Emission Tomography

Published: Monday, January 28, 2013
Last Updated: Monday, January 28, 2013
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This study aimed to use C-11 labeled alcohol, and C-11 and deuterium dual labeled alcohol, as a pair of PET tracers to study alcohol ADME in the baboon including its metabolism within the various organs.

Background and Purpose
The sensitivity to the intoxicating effects of alcohol as well as its adverse medical consequences differ markedly among individuals, which reflects in part differences in alcohol's absorption, distribution, metabolism, and elimination (ADME) properties. The ADME of alcohol in the body and its relationship with alcohol's brain bioavailability, however, is not well understood.

This article was published online in PLoS one and is free to access.


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