Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Discovering the Secrets of Tumour Growth

Published: Monday, January 28, 2013
Last Updated: Monday, January 28, 2013
Bookmark and Share
Scientists have identified a compound that blocks the expression of a protein without which certain tumours cannot grow.

This compound has the potential as an anticancer agent according to the research published in the journal CHBIOL: Chemistry and Biology this week.

The BLM protein is also known to be important in maintaining stability in cells when they multiply, thus preventing cancer. However, certain types of tumour need BLM to grow. This is typical of osteosarcomas - aggressive malignant tumours often seen in bone cancer – and also soft tissue sarcomas.

Now for the first time scientists have been able to turn off the BLM function in cells using an inhibitor called ML216, which stops cells that express BLM from multiplying, leaving cells without BLM alone.

Tumour treatment one step closer

Professor Ian D. Hickson, who led the research says: “Sarcomas and especially osteosarcomas are notoriously difficult to treat. This compound has the potential to lead to a treatment that could stop such tumours growing.”

Professor Hickson’s team is now working on finding derivatives of the compound that will be more potent and suitable to use as a basis for a drug.

“Once we have the compound in the right form, the next step is to test it using mice as a model and then, all being well, to move on to a clinical trial. However, we are several years off having an actual treatment.” He says.

The Nordea Center for Healthy Ageing was founded at the University of Copenhagen in 2008 thanks to funding from the Nordea Foundation. The centre focuses on interdisciplinary research into how people can live healthy lives and enjoy a robust old age.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Discovery Accelerates Targeted Cancer Treatment
In collaboration with international scientists, researchers from the University of Copenhagen have developed a method to help shorten the road to better cancer treatment.
Monday, May 11, 2015
World’s Tiniest Drug Cabinets could be Attached to Cancerous Cells for Long Term Treatment
Reservoirs of pharmaceuticals could be manufactured to bind specifically to infected tissue such as cancer cells for slow, concentrated delivery of drug treatments.
Wednesday, January 15, 2014
Genetic Aberration Paves the Way for New Treatment of Cancer Disease
Research was recently published in Scandinavian Journal of Gastroenterology.
Friday, November 08, 2013
Great Potential for Faster Diagnoses with New Method
The more accurately we can diagnose a disease, the greater the chance that the patient will survive.
Monday, October 21, 2013
New Bio Bank to Resolve Legal and Ethical Issues
When researchers collect human tissue in a so-called bio bank, the purpose is usually to learn about various diseases and improve curing of them.
Tuesday, October 15, 2013
New Protein Knowledge Offers Hope for Better Cancer Treatment
Researchers have developed a sophisticated method for identifying modified proteins that affect a cell's ability to repair DNA damage.
Friday, September 20, 2013
EU Funding for Clinical Trials of a Placental Malaria Vaccine
PlacMalVac project has received an FP7 EU grant.
Tuesday, March 05, 2013
Protein Paves the Way for Correct Stem Cell Differentiation
Research from BRIC, University of Copenhagen, has identified a crucial role of the molecule Fbxl10 in differentiation of embryonic stem cells.
Monday, February 11, 2013
Grants Attract Top Researchers to Copenhagen
Two international leading researchers have each been awarded a Novo Nordisk Foundation Laureate Research Grant of DKK 40 million (€ 5.36 million).
Monday, January 28, 2013
Stem Cells Develop Best in 3D
Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen are contributing important knowledge about how stem cells develop best into insulin-producing cells.
Monday, November 26, 2012
Reconsidering Cancer's Bad Guy
Researchers at the University of Copenhagen have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.
Tuesday, November 20, 2012
Waking the Dead - Scientists Reconstruct the Nuclear Genome of an Extinct Human Being
The discovery improves our understanding of heredity and the disease risk passed down from our ancestors, Copenhagen scientists say.
Monday, February 15, 2010
Isolation of a new Gene Family Essential for Early Development
Researchers have identified a new gene family essential for embryonic development that may contribute to the understanding of the development of cancer.
Thursday, August 23, 2007
University of Copenhagen Wins Novo Nordisk Grant to Build Proteomics Center
The University of Copenhagen in Denmark plans to use a KRO 600 million grant from the Novo Nordisk Foundation to build a protein research center.
Monday, May 07, 2007
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Revolutionary Technologies Developed to Improve Outcomes for Lung Cancer Patients
Breath test to detect lung cancer brings oxygen directly to the wound.
NIH Supports New Studies to Find Alzheimer’s Biomarkers in Down Syndrome
Initiative will track dementia onset, progress in Down syndrome volunteers.
Dementia Linked to Deficient DNA Repair
Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer’s disease.
Using Drug-Susceptible Parasites to Fight Drug Resistance
Researchers at the University of Georgia have developed a model for evaluating a potential new strategy in the fight against drug-resistant diseases.
Boosting Breast Cancer Treatment
To more efficiently treat breast cancer, scientists have been researching molecules that selectively bind to cancer cells and deliver a substance that can kill the tumor cells, for several years.
New Gene Map Reveals Cancer’s Achilles’ Heel
Team of researchers switches off almost 18,000 genes
New Discovery Sheds Light on Disease Risk
Gaps between genes interact to influence the risk of acquiring disease.
How Cells ‘Climb’ to Build Fruit Fly Tracheas
Mipp1 protein helps cells sprout “fingers” for gripping.
Research Finding Could Lead to Targeted Therapies for IBD
Findings published online in Cell Reports.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos