Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Slow-Release "Jelly" Novel Drug Deliverer

Published: Wednesday, January 30, 2013
Last Updated: Wednesday, January 30, 2013
Bookmark and Share
Biomedical engineers have developed a novel method to overcome the major hurdles facing a promising new class of peptide drugs to treat diseases such as diabetes and cancer.

For example, the hormone insulin is a peptide, which regulates the metabolism of carbohydrates in the body and is used as a drug to treat diabetes. There are more than 40 peptide drugs approved for use in humans and more than 650 are being tested in clinical studies.

However, despite their effectiveness, these peptide drugs cannot achieve their full potential for a number of reasons. First, they are rapidly degraded in the blood stream. A second major drawback is their rapid clearance from the body, which requires multiple, frequent injections. Because of this, their concentrations in the blood can rise precipitously right after injection and fall dramatically soon thereafter, causing unwanted side effects for patients.

One popular method to solve this problem involves loading peptide drugs into polymer microspheres that are injected under the skin and slowly degrade and release the peptide drug.   Microsphere-release technology has proven useful, but has many issues related to its manufacture and ease of patient use, the researchers said.

“We wanted to know if we could create a system that does what the polymer microspheres do, but gets rid of the microspheres and is more patient friendly,” said Ashutosh Chilkoti, Theo Pilkington Professor of Biomedical Engineering at Duke’s Pratt School of Engineering.

The new approach involves making a “fusion protein” that consists of multiple copies of a peptide drug fused to a polymer that makes the fusion protein sensitive to body heat. The fusion molecule is a liquid in a syringe but transforms into a “jelly” when injected under the skin.  Enzymes in the skin attack the depot and liberate copies of the peptide, which provides a constant and controllable release of drug over time.

Miriam Amiram, former Chilkoti graduate student and first author on the paper, dubbed the new delivery system POD, for protease-operated depot.

In the latest experiments, published on-line in the journal Proceedings of the National Academy of Science, the researchers fused glucagon-like peptide-1 (GLP-1), a hormone that regulates the release of insulin, with a genetically engineered heat sensitive polymer to create the POD.

“Remarkably, a single injection of the GLP-1 POD was able to reduce blood glucose levels in mice for up to five days, which is 120 times longer than an injection of the peptide alone,” Chilkoti said.  “For a patient with type 2 diabetes, it would be much more desirable to inject such a drug once a week or once a month rather than once or twice a day.

“Additionally, this approach avoids the peaks and valleys of drug concentrations that these patients often experience,” Chilkoti said.

Unlike peptide-loaded microspheres, PODs are also easy to manufacture, as the peptide drug and the heat-sensitive polymer are all made of amino acids, so that they are expressed as one long stretch of amino acids in bacteria.

“Our experiments demonstrate that this new delivery system provides the first entirely genetically encoded alternative to existing peptide drug encapsulation approaches for sustained delivery of peptide drugs,” Chilkoti said.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Poverty Marks a Gene, Predicting Depression
New study of high-risk teens reveals a biological pathway for depression.
Thursday, May 26, 2016
Poliovirus Therapy Wins 'Breakthrough' Status
FDA decision will fast-track research on breakthrough Duke brain cancer therapy.
Wednesday, May 18, 2016
Enzyme Structure May Aid Antibiotic Development
Targeted enzyme is essential to every known strain of bacteria.
Wednesday, April 20, 2016
Coding and Computers Help Spot Methane, Explosives
Coded apertures improve and shrink mass spectrometers for field use.
Tuesday, April 19, 2016
Why Bearcats Smell Like Buttered Popcorn
Researchers pinpoint chemical compound that gives rare animal its popcorn-like scent.
Friday, April 15, 2016
Antibiotics Don't Promote Swapping of Resistance Genes
Bacterial resistance spreads through population dynamics, not an increase in gene transfers.
Wednesday, April 13, 2016
Genetic Elements that Drive Regeneration
Limb or organ regrowth may be hidden in our genes.
Friday, April 08, 2016
Immunity Genes Could Protect Some From E. Coli
When a child comes home from preschool with a stomach bug that threatens to sideline the whole family for days, why do some members of the family get sick while others are unscathed?
Monday, January 25, 2016
Disrupting Cell’s Supply Chain Freezes Cancer Virus
When the cancer-causing Epstein-Barr virus moves into a B-cell of the human immune system, it tricks the cell into rapidly making more copies of itself, each of which will carry the virus.
Thursday, January 21, 2016
Slow Stem Cell Division May Cause Small Brains
Delayed neural stem cells make the wrong cells during development.
Tuesday, January 12, 2016
Travelling Salesman Uncorks Synthetic Biology Bottleneck
Computer program scrambles genetic codes for production of repetitive DNA and synthetic molecules.
Thursday, January 07, 2016
Catching Cellular Impacts of Bubbles and Jets
New technique captures diverse effects of cavitation bubbles on individual cells.
Thursday, December 10, 2015
Cellular Stress Process Identified in Cardiovascular Disease
Combining the investigative tools of genetics, transcriptomics, epigenetics and metabolomics, a Duke Medicine research team has identified a new molecular pathway involved in heart attacks and death from heart disease.
Tuesday, November 10, 2015
Molecular ‘Kiss Of Death’ Flags Pathogens For Destruction
Researchers have discovered that our bodies mark pathogen-containing vacuoles for destruction by using a molecule called ubiquitin, commonly known as the "kiss of death."
Wednesday, September 30, 2015
Newly Identified Biochemical Pathway Could Be Target for Insulin Control
Researchers at Duke Medicine and the University of Alberta are reporting the identification of a new biochemical pathway to control insulin secretion from islet beta cells in the pancreas, establishing a potential target for insulin control.
Tuesday, September 29, 2015
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!