Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Recently Identified Immune Cells Possible Therapeutic Target for Eczema

Published: Wednesday, February 06, 2013
Last Updated: Wednesday, February 06, 2013
Bookmark and Share
The increasing incidence of allergic skin diseases have spurred researchers to look for better ways to control these immune system-based disorders.

Atopic dermatitis, more commonly called eczema, now affects 10 to 20 percent of children in the United States and direct health-care costs exceed $3 billion, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases.  What’s more, up to 50 percent of children with atopic dermatitis will develop other allergic diseases, including asthma, a phenomenon termed the “allergic march,” the gradual acquisition of co-existing allergic diseases.

David Artis, Ph.D., associate professor of Microbiology, and Brian Kim, M.D., clinical instructor of Dermatology, from the Perelman School of Medicine, University of Pennsylvania, have identified a previously unknown critical role for a recently identified immune cell population in the progression of atopic dermatitis. They describe their findings in the latest issue of Science Translational Medicine.

The team found an accumulation of innate lymphoid cells (ILCs) in the active lesions of patients with atopic dermatitis. Using a mouse model of atopic dermatitis they also showed that mouse ILCs contribute to disease progression.  These studies suggest ILCs may be a new therapeutic target in treating the development and severity of atopic dermatitis.

Under the Skin

“Like foot soldiers protecting the skin barrier from onslaught, innate lymphoid cells are present in healthy skin and we would predict that these cells play a role in maintaining normal tissue function and perhaps in protecting against microbes on this barrier,” says Artis. “However, in chronic inflammatory diseases like atopic dermatitis, unchecked innate lymphoid cell responses can promote inflammation.”

Kim adds, “A potential consequence of our more hygienic environment is that immune cells may be left somewhat redundant and so contribute to the increasing incidence of allergic diseases like eczema.”

Many studies before the current one in STM have identified immune pathways that activate ILCs in such other tissues as the intestine and lung. “An unexpected finding of the current study is that innate lymphoid cells in the skin appear to be activated and regulated by different pathways,” says Kim. “These findings suggest that tissue-specific local signals may regulate their function. This finding may also offer therapeutic potential to selectively target innate lymphoid cells in certain tissues, especially for limiting disease severity.”

At present, the first-line therapy for atopic dermatitis remains topical steroids. Unlike other inflammatory diseases like psoriasis and arthritis that can be treated with modern biologic-based therapies, there are no targeted biologic therapies that are approved for use to treat atopic dermatitis.

“Our findings give us hope that new biologic therapies may be designed to treat atopic dermatitis in the future,” says Artis.

These studies are part of a new collaboration between basic scientists in Penn’s Department of Microbiology and Institute for Immunology, along with clinicians at Penn’s Department of Dermatology.  These studies are supported by the National Institutes of Health’s Clinical and Translational Science Award program, which is administered through Penn’s Institute for Translational Medicine and Therapeutics.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Study Questions Presence in Blood of Heart-Healthy Molecules from Fish Oil Supplements
A new study from the Perelman School of Medicine at the University of Pennsylvania questions the relevance of fish oil-derived SPMs and their purported anti-inflammatory effects in humans.
Monday, August 03, 2015
Limber Lungs: One Type of Airway Cell Can Regenerate Another Lung Cell Type
Findings from animal study have implications for disorders such as chronic obstructive pulmonary disease.
Tuesday, April 14, 2015
New Approach to Promote Regeneration of Heart Tissue
Study in animal model paving way forward for tissue repair.
Thursday, March 19, 2015
Penn Researchers Tame the Inflammatory Response in Kidney Dialysis
Researchers temporarily suppress complement during dialysis to avoid these problems.
Saturday, December 13, 2014
First Atlas of Body Clock Gene Expression in Mammals Informs Timing of Drug Delivery
Penn Medicine study has implications for 100 top-selling US drugs, half of which target daily-oscillating genes.
Thursday, October 30, 2014
Study Identifies Potential Treatment Target for Cocaine Addiction
Small change in receptor subunit reduces cocaine seeking in an animal model of addiction.
Thursday, October 30, 2014
Funding for DNA Vaccines to Fight Infectious Disease
DARPA awards $12 million to Penn-led group to develop synthetic DNA vaccines to fight infectious disease.
Wednesday, October 22, 2014
Personalized Cellular Therapy Achieves Complete Remission in 90 Percent of ALL Patients Studied
University of Pennsylvania and Children's Hospital of Philadelphia studies reveal unprecedented results with investigational therapy made from patients' own immune cells.
Friday, October 17, 2014
Ovarian Cancer Oncogene Found in "Junk DNA"
The study is published online in this week in Cancer Cell.
Wednesday, September 10, 2014
Activating Pathway Could Restart Hair Growth in Dormant Hair Follicles
Manipulation of the Wnt/ß-catenin signaling pathway could provide therapeutic targets for hair loss, unwanted hair growth and skin cancer.
Tuesday, December 10, 2013
Researchers Identify Four New Genetic Risk Factors for Testicular Cancer
Large, first-of-its-kind study finds genomic regions associated with higher risk.
Wednesday, May 15, 2013
Newly Described Type of Immune Cell and T Cells Share Similar Path to Maturity
Better understanding of cells' development has implications in study of inflammatory diseases.
Wednesday, May 15, 2013
T-Cell Therapy Eradicates an Aggressive Leukemia in Two Children
CHOP/Penn Medicine oncology team reports complete remission in pediatric ALL patients.
Tuesday, March 26, 2013
Study Confirms No Transmission of Alzheimer's Proteins between Humans
No evidence to show that proteins can spread around within the brain or between animals and humans.
Wednesday, February 06, 2013
Changes to DNA On-Off Switches Affect Cells' Ability to Repair Breaks
Many proteins are involved in everyday DNA repair, but if they are mutated, the repair system breaks down and cancer can occur.
Wednesday, February 06, 2013
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!