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Oncolytics Announces Additional Positive REOLYSIN® Clinical Trial Data from Phase 2 Study

Published: Monday, February 11, 2013
Last Updated: Sunday, February 10, 2013
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Study enroll patients with metastatic or recurrent squamous cell carcinoma of the lung.

Oncolytics Biotech Inc. has announced results examining percent overall tumour shrinkage data from its U.S. Phase 2 clinical trial in patients with squamous cell carcinoma of the lung (SCCLC) using intravenous administration of REOLYSIN® in combination with carboplatin and paclitaxel (REO 021).

The analysis examined percent best overall tumour changes between pre-treatment and up to six treatment cycles.

Of 20 evaluable patients, 19 (95%) exhibited overall tumour shrinkage, (mean (20 patients): 33.7% shrinkage).

A waterfall graph showing individual patient data will be available on the Company's website at http://www.oncolyticsbiotech.com/presentations.

"It's exciting to have 95% of patients in this study exhibit tumour shrinkage and these results further suggest that REOLYSIN may have potential use in neoadjuvant (pre-surgical) settings," said Dr. Brad Thompson , President and CEO of Oncolytics.

Dr. Thompson continued, "Based on these findings we intend to continue to look at REOLYSIN as a treatment for cancers of the lung and cancers that metastasize to the lung."

The study enrolled patients with metastatic or recurrent squamous cell carcinoma of the lung.

The primary endpoint of the study is objective tumour response rates, and the secondary objectives include progression free survival and overall survival.

To date, the Company has observed nine partial responses (PR), nine stable disease (SD) and three progressive disease (PD) by RECIST criteria for a disease control rate (complete response (CR) + PR + SD)) of 86%. The study continues to enroll patients.


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