Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Researcher Taking Shot at Flu Vaccine That's More Effective, Easier to Make

Published: Monday, February 11, 2013
Last Updated: Monday, February 11, 2013
Bookmark and Share
In the midst of an unusually deadly flu season and armed with a vaccine that only offers partial protection, researcher is working on a flu vaccine that overcomes the need to predict which strains will hit each year.

This year's vaccine is 62 percent effective or "moderately" effective against the current flu strains, according to early estimates from the Centers for Disease Control and Prevention. Flu-related deaths this season have reached an epidemic level and include 45 children, according to the most recent report.

Suresh Mittal, a professor of comparative pathobiology in Purdue's College of Veterinary Medicine, is applying a method he developed for an avian flu vaccine to create a more universal seasonal flu vaccine. The vaccine's protection could persist through different strains and mutations of the influenza virus and would not be dependent on accurate predictions of the strains expected each season, he said.

"This method allows us to create a vaccine that targets core parts of the influenza virus that are found across all strains and don't mutate or change quickly," Mittal said. "It also allows us to target multiple parts of the virus, so that even if the virus adapts to one line of attack, there are others that will still work to prevent the illness."

The method uses a harmless adenovirus as a vector to deliver influenza virus genes into the body where they create a two-fold immune response of antibody and cell-based protection. The adenovirus releases the genes inside the host cells, which then create proteins that lead to the creation of antibodies and special T-cells primed to kill influenza virus and any cells infected by it.

"This method works beyond that of the current vaccine, in which the body responds to inactivated virus proteins injected into a muscle," Mittal said. "Getting the influenza virus genes inside the cells better mimics an infection and leads to a more powerful and multifaceted immune response, so we are better prepared to fend off a true infection."

Any genes important to influenza virus protection can be incorporated into the adenovirus vector, and it can be designed to expose the immune system to components from both the surface and deep within the virus. In this way the immune system can be primed to recognize portions of the virus that are the same across all strains and those that are more difficult for the virus to change as it adapts to the immune system attack, he said.

The new vaccine also has manufacturing advantages over current methods because the vector is easily grown in cell culture. The current flu vaccine depends on the growth of influenza viruses in chicken eggs.

"Sometimes the virus strains selected for the year's vaccine do not grow well in an egg and that can lead to delays or shortages of the vaccine," Mittal said. "The new method depends only on the growth of the virus vector, which we know how to grow quite well. The influenza strains we select to include have no effect on the growth or the amount of vaccine that can be made."

Mittal said vaccination is critical to save lives.

"We don't think of the flu as a killer, but it kills around 35,000 people each year," he said. "Even when the flu vaccine isn't a perfect match, it still offers the best protection. It also is important to get vaccinated to help prevent the spread of the virus to those who are too young or too sick to be vaccinated themselves."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Remote-Controlled Drug Delivery
A team of researchers has created a new implantable drug-delivery system using nanowires that can be wirelessly controlled.
Thursday, June 25, 2015
Microsecond Raman Imaging Might Probe Cells, Organs for Disease
An advanced medical diagnostic tool for the early detection of cancer and other diseases.
Thursday, April 02, 2015
Purdue-Based Firms Grow After Receiving Emerging Innovations Fund Investments
The Fund has helped to support new business ventures across a range of research areas.
Friday, March 13, 2015
Keck Foundation to Fund Purdue Research into Spectroscopic Imaging
Ji-Xin Cheng leads a Purdue team awarded a $1 million W.M. Keck Foundation grant to develop a new type of imaging technology for cell and tissue analysis that could bring advanced medical diagnostics.
Tuesday, February 10, 2015
Pharmaceuticals, Personal Care Products Could Taint Swimming Pools
A new study suggests pharmaceuticals and chemicals from personal care products end up in swimming pools, possibly interacting with chlorine to produce disinfection byproducts with unknown properties and health effects.
Monday, January 12, 2015
Purdue Research Suggests Approach to Treat Virus Causing Respiratory Illness
Enterovirus D68 has stricken children with serious respiratory infections.
Monday, January 05, 2015
Drinking Water Odors, Chemicals Above Health Standards Caused by 'Green Building' Plumbing
Several types of plastic pipes in eco-friendly green buildings in the United States have been found to leach chemicals into drinking water that can cause odors and sometimes exist at levels that may exceed health standards.
Tuesday, October 21, 2014
New Technique Yields Drug, Biomedical Test Results in One Minute
Slug flow microextraction makes it possible to quickly detect the presence of drugs or to monitor certain medical conditions using only a single drop of blood or urine.
Tuesday, October 14, 2014
Producing Orange Corn Rich in Provitamin A
Improvement of carotenoid levels in corn a simpler, faster process for plant breeders.
Saturday, October 11, 2014
New Chip Promising For Tumor-Targeting Research
The new system, called a tumor-microenvironment-on-chip device, will allow researchers to study the complex environment surrounding tumors and the barriers that prevent the targeted delivery of therapeutic agents.
Tuesday, September 23, 2014
Mass Spectrometry Tool Helps Guide Brain Cancer Surgery
A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.
Wednesday, July 02, 2014
System 'Prints' Precise, Tailored Drug Dosages
The new approach uses a combination of data and mathematics to determine the precise dosage.
Friday, May 16, 2014
Purdue, Houston Methodist to Take Drug Discoveries from the Bench Top to the Bedside
The planned collaboration on research and educational initiatives includes clinical trials of drugs developed at Purdue.
Monday, March 17, 2014
Helping Genes Get Out of the Starting Blocks Faster
Yeast can quickly adapt to changes in its environment with the help of molecules known as long non-coding RNAs, a Purdue study shows.
Friday, February 21, 2014
Laser Tool Speeds up Detection of Salmonella in Food Products
Purdue University researchers have developed a laser sensor that can identify Salmonella bacteria grown from food samples about three times faster than conventional detection methods.
Sunday, February 16, 2014
Scientific News
Genetic Defences of Bacteria Don’t Aid Antibiotic Resistance
Genetic responses to the stresses caused by antibiotics don’t help bacteria to evolve a resistance to the medications, according to a new study by Oxford University researchers.
Detecting HIV Diagnostic Antibodies with DNA Nanomachines
New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and auto-immune diseases such as rheumatoid arthritis and HIV.
Snapshot Turns T Cell Immunology on its Head
New research may have implications for 1 diabetes sufferers.
Tolerant Immune System Increases Cancer Risk
Researchers have found that individuals with high immunoCRIT ratios may have an increased risk of developing certain cancers.
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
New Approach to Treating Heparin-induced Blood Disorder
A potential treatment for a serious clotting condition that can strike patients who receive heparin to treat or prevent blood clots may lie within reach by elucidating the structure of the protein complex at its root.
Horse Illness Shares Signs of Human Disease
Horses with a rare nerve condition have similar signs of disease as people with conditions such as Alzheimer’s, a study has found.
How a Molecular Motor Untangles Protein
Diseases such as Alzheimer’s, Parkinson’s and prion diseases, all involve “tangled” proteins.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos