Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Thermo Scientific Introduces Automated Sample Prep/LC System

Published: Tuesday, February 12, 2013
Last Updated: Tuesday, February 12, 2013
Bookmark and Share
Designed to make LC-MS/MS analysis accessible to more clinical researchers.

Thermo Fisher Scientific, Inc. has introduced the Thermo Scientific Prelude SPLC sample preparation and liquid chromatography system, developed to make analysis of target compounds in complex biological matrices routine for clinical research and forensic toxicology laboratories.

LC-MS/MS offers significant advantages in selectivity and quantitative accuracy over immunoassays and other analytical techniques, according to numerous published studies.

However, Thermo Fisher Scientific “Voice of the Customer” surveys indicate that many clinical researchers consider the need for specialized mass spectrometry expertise a barrier to adopting this powerful technology.

“Our intent is to demonstrate how easy it now can be to perform LC-MS/MS bioanalysis on a routine basis,” said Ken Miller, Thermo Fisher vice president, Marketing, Life Science Mass Spectrometry.

Miller continued, “As the clinical research community increasingly recognizes the benefits of LC-MS/MS, we set a goal to make this technique more accessible than it is with standard HPLC systems. To do this, we designed a front end of the MS workflow emphasizing robustness, affordable cost of ownership and better ease of use. We feel that the Prelude SPLC system succeeds.”

The Prelude SPLC sample preparation and liquid chromatography system is designed to work seamlessly with Thermo Scientific mass spectrometers such as the Thermo Scientific TSQ Vantage triple-stage quadrupole instrument.

The TSQ Vantage system is known for its very high sensitivity and low noise, enabling quantitative analysis and positive identification of drugs, drug metabolites and steroids in biological samples.

The Prelude SPLC system is designed to enhance the cost effectiveness of LC-MS/MS instrumentation by automating sample preparation and increasing mass spectrometer throughput.

Automation can minimize variability inherent in manual sample preparation procedures while also reducing sample preparation time and effort.

Innovative Thermo Scientific TurboFlow technology is designed to negate problems caused by sample matrix interference while capturing analytes of interest.

This level of sample clean-up can enhance MS quantitative analysis by reducing ion suppression. Contamination of the mass spectrometer ion source can also be reduced, minimizing maintenance requirements.

The Prelude SPLC system can contribute to reductions in operating costs for research laboratories that currently outsource LC-MS/MS analysis by bringing this capability in-house.

Because it features two channels of high-performance liquid chromatography (HPLC) separation, mass spectrometer idle time can be reduced compared to single channel LC systems. This often translates into higher sample throughput.

LC-MS/MS performance can be further enhanced through precise and reproducible low-volume gradient operation at flow rates of 1-2000 µL/min, which can enable fast, high-resolution separations compared to standard HPLC systems.

Ease of use is enhanced by Thermo Scientific TraceFinder software, which provides a single, easy-to-learn interface for both the LC and MS functions. These include instrument control, data acquisition, data processing and reporting.

Thermo Scientific Quick Start methods are designed to facilitate implementation of LC/MS for users who may not be mass spectrometry experts. Once a method is loaded, users can begin running samples with as few as six clicks of the mouse.

The Prelude SPLC system software features a remote instrument monitoring and diagnostics capability, designed to reduce the need for on-site troubleshooting skills. Thermo Scientific technicians can pinpoint hardware problems online.

The Prelude SPLC system is manufactured at an ISO 13485 certified Thermo Fisher facility. ISO 13485 is an internationally recognized standard of quality management.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo and DuPont Extend Food Safety Agreement
Thermo Fisher scientific and DuPont Nutrition & Health extend BAX System Q7 Distribution agreement in Western Europe for an additional three years.
Thursday, July 14, 2016
Thermo Fisher, Cytonome/ST Announce Partnership
Partnership aims to focus on the development of a new line of flow cytometry cell sorting platforms.
Tuesday, June 28, 2016
Thermo Recognizes Tandem Mass Tag Grant Award Winners at ASMS 2016
International competition rewards three top proteomics researchers for outstanding innovation and impact.
Thursday, June 09, 2016
Native Mobile Capabilities Added to Thermo SampleManager
One of world’s most widely deployed LIMS continues to add functionality that modern labs require.
Monday, March 14, 2016
Thermo, Children’s Hospital Los Angeles Partner
Children’s Hospital Los Angeles (CHLA) and Thermo Fisher Scientific have agreed to develop a next-generation sequencing (NGS)-based panel designed specifically for pediatric cancer research. The assay would be CHLA’s first NGS panel designed to target biomarkers associated with childhood cancers.
Friday, February 19, 2016
Thermo Scientific Gemini Handheld Chemical Analyzer Wins R&D 100 Award
Two-in-one portable device also earns Editor’s Choice in Analytical/Test category for 2015 by R&D Magazine.
Thursday, November 26, 2015
Thermo Scientific Signs Agreement with Novartis, Pfizer
Universal test designed for non-small cell lung cancer supports multiple drug development programs.
Thursday, November 26, 2015
Thermo Scientific Opens New GMP Clinical Services Facility in Singapore
New regional BioPharma Services hub offers larger operational space and advanced equipment to meet increasing clinical supply needs for pharma and biotech customers.
Saturday, November 21, 2015
Thermo Scientific Manufacturing Site to Meet Guidelines for 18385 Certification
A new standard proposed by the International Organization for Standardization.
Thursday, October 15, 2015
Thermo Fisher Scientific Announces Winners of 2016 Winter Conference Awards in Plasma Spectrochemistry
Independent committee recognizes significant contributions in plasma spectrochemistry.
Wednesday, September 23, 2015
Thermo Fisher Scientific Receives IVDD CE Mark for LC-MS Products
Now available to clinical laboratories in Europe for general in vitro diagnostic use.
Friday, September 11, 2015
Thermo Launches Geneticon
Thermo Fisher Scientific launches GenetiCon, a virtual resource showcasing the real-life science behind superheroic powers and more.
Tuesday, July 07, 2015
Thermo Fisher Agrees to Buy Alfa Aesar for $403M
The company announced a definitive agreement to buy the research chemical manufacturer for $403 million.
Friday, June 26, 2015
Ebola Sequencing Data Released to Global Research Community Online
To curb further spread of Ebola in Sierra Leone, a team of scientists that is part of an international, multi-organizational effort has released their first dataset of the virus’ genetic structure online.
Wednesday, June 03, 2015
Thermo's NGS Platform Selected for Nationwide Clinical Research Program
National Cancer Institute-MATCH trial to sequence thousands of tumor samples using Ion Torrent targeted sequencing technology.
Monday, June 01, 2015
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Flu Vaccine May Reduce Risk of Death For Type 2 Diabetes Patients
Researchers at Imperial College London have suggested that the vaccine may have substantial benefits for patients with long-term conditions.
Cancer Gene-Drug Combinations Ripe for Precision Medicine
The study aims to expand the number of cancer gene mutations that can be paired with a precision therapy.
Porphyrins as Catalysts in Scalable Organic Reactions
This review covers the most relevant scalable porphyrin-catalysed procedures, showing how these compounds represent broad applications in chemistry.
CDC Updates Zika Recommendations
CDC has issued updated Zika recommendations and guidance for healthcare providers with a focus on sexual transmission.
Exploiting Malaria’s Achilles’ Heel
Researchers have uncovered an Achilles' heel in malaria's anti-drug treatment arsenal that could lead to a disease cure.
Genome of 6000-Year-Old Barley Sequenced
Researchers have successfully sequenced the genome of Chalcolithic barley grains for the first time.
3D Models May Yield Ovarian Cancer Insights
Researchers are developing new tools to decipher ovarian cancer developments through a 3D printing technology.
Targeting BRAF Mutations in Thyroid Cancer
Treating metastatic thyroid cancer patients harboring a BRAF mutation with vemurafenib showed anti-tumor activity in a third of patients.
Plant Compounds Fight Together Against Colon Cancer
Research shows treating colon cancer cells with curcumin, then silymarin is more effective than treatment with each individually.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!