Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

€9m EU-project on Deep-Sea Organisms Started

Published: Friday, February 15, 2013
Last Updated: Friday, February 15, 2013
Bookmark and Share
The PharmaSea project will evaluate the potential of new bioactive compounds from marine organisms as novel drug leads or ingredients for nutrition or cosmetic applications.

The collaborative project PharmaSea will bring European researchers to some of the deepest, coldest and hottest places on the planet. Scientists from the UK, Belgium, Norway, Spain, Ireland, Germany, Italy, Switzerland and Denmark will work together to collect and screen samples of mud and sediment from huge, previously untapped, oceanic trenches. The large-scale, four-year project is backed by more than €9.5 million of EU funding and brings together 24 partners from 14 countries from industry, academia and non-profit organisations.

The PharmaSea project focuses on biodiscovery research and the development and commercialisation of new bioactive compounds from marine organisms, including deep-sea sponges and bacteria, to evaluate their potential as novel drug leads or ingredients for nutrition or cosmetic applications. The international team of scientists is led by Professor Marcel Jaspars of the University of Aberdeen in Scotland, and coordinated by Dr. Camila Esguerra of the University of Leuven in Belgium. 

One of the aims of PharmaSea is to discover new marine bacteria that can produce novel antibiotics: "There’s a real lack of good antibiotics in development at the moment. There hasn’t been a completely new antibiotic registered since 2003. If nothing’s done to combat this problem we’re going to be back to a ‘pre-antibiotic-era’ in around ten or twenty years, where bugs and infections that are currently quite simple to treat could be fatal", says Marcel Jaspars, who is Professor of Chemistry and Director of the Marine Biodiscovery Centre at the University of Aberdeen. PharmaSea will also focus on drug discovery for neurological, inflammatory, and other infectious diseases.

Only a handful of samples have ever been taken from deep trenches and investigated, so the project is breaking new ground. "PharmaSea will not only be exploring new territory at the bottom of the oceans, but also new areas in ‘chemical space’. With our broad platform of cutting-edge bioassays to detect drug-like activity, we'll be testing many unique chemical compounds from these marine samples that have literally never seen the light of day. We're quite hopeful that we'll find a number of exciting new drug leads", says Dr. Camila Esguerra, Industrial Research Fellow and Lecturer with the Laboratory for Molecular Biodiscovery at the University of Leuven.

The international team will employ strategies commonly used in the salvage industry to carry out the sampling. Using fishing vessels, researchers will drop a sampler on a reel of cables to the trench bed to collect sediment. Scientists will then attempt to grow unique bacteria and fungi from the sediment that can be extracted to isolate novel drug-like molecules for pharmacological testing. Partners from China, Chile, Costa Rica, New Zealand and South Africa will support the PharmaSea project. The first field tests will be carried out next autumn in the Atacama Trench in the Eastern Pacific Ocean, about 100 miles off the coast of Chile and Peru. The team will also search the Arctic waters off Norway and the Antarctic via Italian and South African partners. Deep trenches will also be accessed off New Zealand and China.

Marine organisms that live more than 6,000 meters below the sea level are considered to be an interesting source of novel bioactive compounds as they survive under extreme conditions. "Trenches are separated from each other and represent islands of diversity. They are not connected to each other and life has evolved differently in each one", explains Marcel Jaspars. 


 • University of Leuven (Belgium)

The University of Aberdeen (UK)

Aquapharm Biodiscovery Ltd (UK)

University of Tromsø (Norway)

eCoast Research Centre (Belgium)

Biobridge Ltd (UK)

Fundación MEDINA (Spain)

University College Cork, National University of Ireland

BIOCOM AG (Germany)

Stazione Zoologica Anton Dohrn (Italy)

Consiglio Nazionale delle Ricerche ibp-cnr (Italy)

University of Santiago de Compostela (Spain)

The Royal Society of Chemistry (UK)

c-LEcta GmbH (Germany)

Technical University of Denmark

Deep Tek Ltd (UK)

Advanced Chemistry Development UK Ltd

Wuhan University (China)

Institute of Microbiology – Chinese Academy of Sciences (China)

University of the Western Cape (South Africa)

Institute for Cell Dynamics and Biotechnology (Chile)

National Biodiversity Institute of Costa Rica

International Union for Conservation of Nature (Switzerland)

University of Waikato (New Zealand)

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

RTI Launches New Spectral Database for Forensic Laboratories, Research and Law Enforcement
RTI International, funded by a grant from the National Institute of Justice (NIJ), has created 'Forensic DB', a cheminformatics database for the retention, review, and ongoing collection of spectroscopic data pertaining to toxins, drugs, and other compounds of interest to the forensics community.
Wednesday, December 08, 2010
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos