Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Type of Pluripotent Cell Discovered In Adult Breast Tissue

Published: Tuesday, March 05, 2013
Last Updated: Tuesday, March 05, 2013
Bookmark and Share
Human body carries personalized “patch kit," Say UCSF scientists.

UC San Francisco researchers have found that certain rare cells extracted from adult breast tissue can be instructed to become different types of cells – a discovery that could have important potential for regenerative medicine.

As with human embryonic stem cells, the newly found cells are pluripotent, or capable of turning into most cell types, the authors said. The scientists discovered that when the cells were put either in mice, or in cell culture, the cells could differentiate to produce multiple cell types, including those that proceed to make heart, intestine, brain, pancreas and even cartilage.
The finding is significant, the authors said, because scientists previously believed that pluripotent cells did not exist in the body after the embryonic stage of human development.

While a therapeutic use of the cells has yet to be determined, they could potentially generate new tissue – a “patch kit" – to heal wounds or reconstruct damaged or missing organs. They also could be used as a resource to study how cells become pluripotent, and how they repair and replace themselves.

“The ability of cells from an adult body to make so many tissue derivatives was completely unexpected,” said senior author Thea D. Tlsty, PhD, a UCSF professor of pathology. “When we saw that they could make cartilage, bone, gut, brain, pancreas cells – and even beating heart tissue – we were excited and intrigued.”

The study was published on Monday, March 4, in the online Early Edition of the Proceedings of the National Academy of Sciences (PNAS).

UCSF has pioneered research on regenerative medicine in a broad array of animal and human cell studies. Last year, Shinya Yamanaka, MD, PhD, a senior investigator at the UCSF-affiliated Gladstone Institutes and a UCSF professor of anatomy, won the Nobel Prize in Medicine for his discovery of a way to reprogram ordinary human skin cells into stem cells that can be used to better understand and treat a number of human diseases. Other projects at UCSF include work by Allan Basbaum, PhD, to modify stem cells to treat pain and rebuild damaged nervous systems.

Unique Characteristics of Newly Discovered Cells

Though the newly discovered cells share some characteristics of embryonic stem cells, they appear to be unique to themselves, said Tlsty. They are mortal and genetically stable – characteristics that are barriers to subsequent cancer formation, which is a factor that could prove valuable if the cells are to be used for regenerative medicine, she explained. By contrast, human embryonic stem cells as well as engineered induced pluripotent stem cells, also known as iPS cells, are immortal and genetically unstable.

Additionally, the cells can expand to an extensive yet finite number before they stop growing. One cell can grow for almost 60 population doublings, producing in excess of one billion daughter cells, conceptually providing enough cells to help in the recovery of damaged or diseased tissue.
The scientists are currently searching for the rare cells in other organs of the body. They hypothesize that these “universal patch kits” are scattered throughout the body of adult men and women.

The special cells were discovered and isolated in healthy breast tissue from women of various ages and ethnicities who were undergoing breast reductions. All tissues used in the study were devoid of visible disease or contamination, the authors say.

The breast tissue in the study was separated into single cells, and specific markers were used to pull out the rare population of cells.

From Breast Tissue to Beating Heart Cells

Even a single one of these endogenous pluripotent somatic (ePS) cells, when placed in the appropriate conditions, exhibited the same pluripotent power to self-renew and to generate multiple lineages – both in vitro and in vivo – as embryonic stem cells. The cells could develop into any of the three germ layers: endoderm (such as the pancreas and gastrointestinal tract), the mesoderm (bone, heart muscle, blood vessel), or ectoderm (breast tissues and nervous system).

For example, when properly instructed, some ePS cells made human breast tissue that produced milk in transplanted mice, while other cells generated cartilage structures. To the surprise of the researchers, when the cells were differentiated into heart muscle, they even demonstrated the spontaneous beating seen in cardiomyocytes, or “beating heart” cells.

“The cells we describe here exist in the body devoid of commitment,” the authors wrote. “Taken together, these studies provide morphological, molecular and functional evidence of lineage plasticity of these cells. They will make human milk, bone, fat – they will beat like a heart.”

Only a small fraction of certain mammary cells have “this complete and sustained” unique profile capable of morphing themselves, the researchers said.

“Future research will tell us if we lose access to these cells as we age, if they are found in all tissues, and if they can be used to rescue diseased tissues,” said Tlsty.

“The observation that rare cells within an adult human body have the capacity to differentiate into many tissue types under different physiological cues will facilitate a fascinating area of research into the physiology and therapeutic potential of these cells,” said lead author Somdutta Roy, PhD, a postdoctoral fellow at the UCSF Department of Pathology and the UCSF Helen Diller Family Comprehensive Cancer Center.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Finding Factors That Protect Against Flu
A clinical trial examining the body’s response to seasonal flu suggests new approaches for evaluating the effectiveness of seasonal flu vaccines.
Wednesday, April 27, 2016
Factors Influencing Influenza Vaccine Effectiveness Uncovered
The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests.
Thursday, April 21, 2016
Study Finds Factors That May Influence Influenza Vaccine Effectiveness
Researchers at NIH have suggested that the long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited.
Wednesday, April 20, 2016
Serotonin Transporter Structure Revealed
Researchers determined the 3-D structure of the serotonin transporter and visualized how two common antidepressants interact with the protein.
Wednesday, April 20, 2016
Improving Flu Vaccine Effectiveness
NIH study finds factors that may influence influenza vaccine effectiveness.
Wednesday, April 20, 2016
Submissions Open for the Cancer Moonshot Program
NCI opens online platform to submit ideas about research for Cancer Moonshot.
Tuesday, April 19, 2016
Migration Creates Cancer Cell Vulnerabilities
Scientists found that migration can damage cancer cells’ nuclei and DNA, requiring repairs for their survival. The results may open new avenues for targeting metastatic cancer.
Wednesday, April 13, 2016
NIH Sequences Genome of a Fungus
Researchers at the Institute have sequenced genome of human, mouse and rat Pneumocystis that cause life-threatening Pneumonia in immunosuppressed hosts.
Tuesday, April 12, 2016
NIH Awards Grants to Explore Vaccine Adjuvants
NIH awards six grants to explore how combination adjuvants improve vaccines.
Wednesday, April 06, 2016
Children With Cushing Syndrome May Have Higher Suicide Risk
Researchers at NIH have found that depression, anxiety and suicidal thoughts increase after treatment.
Wednesday, March 30, 2016
Experimental Vaccine Protects Against Dengue Virus
An experimental dengue vaccine protected all the volunteers who received it from infection with a live dengue virus.
Wednesday, March 30, 2016
Couples’ Pre-Pregnancy Caffeine Consumption Linked to Miscarriage Risk
Researchers at NIH have found daily multivitamin before and after conception greatly reduces miscarriage risk.
Friday, March 25, 2016
Study Finds Mindfulness Meditation Offers Relief For Low-Back Pain
Researchers at NIH have found that the MBSR and CBT may prove more effective than usual treatment in alleviating chronic low-back pain.
Wednesday, March 23, 2016
3-D Technology Enriches Human Nerve Cells For Transplant to Brain
This platform is expected to make transplantation of neurons a viable treatment for a broad range of human neurodegenerative disorders.
Friday, March 18, 2016
Scientists Discover Non-Opioid Pain Pathway in the Brain
Researchers at NIH have discovered evidence for the existence of a non-opioid process in the brain to reduce pain through mindfulness meditation.
Friday, March 18, 2016
Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!