Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Study Maps Human Metabolism in Health and Disease

Published: Tuesday, March 05, 2013
Last Updated: Tuesday, March 05, 2013
Bookmark and Share
Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual's genetic make-up and their lifestyle.

The international team of researchers say their study - published in Nature Biotechnology - provides the best model yet to explain why individuals react differently to environmental factors such as diet or medication.

"This research is the second, important stage of our understanding of the human genome," said study author Professor Pedro Mendes, from The University of Manchester's School of Computer Science. "If the sequencing of the human genome provided us with a list of the biological parts then our study explains how these parts operate within different individuals.

"The results provide a framework that will lead to a better understanding of how an individual's lifestyle, such as diet, or a particular drug they may require is likely to affect them according to their specific genetic characteristics. The model takes us an important step closer to what is termed 'personalised medicine', where treatments are tailored according to the patient's genetic information."

The research, which involved scientists from Manchester, Cambridge, Edinburgh, Reykjavik, San Diego, Berlin, the BBSRC-funded Babraham Institute and many others, mapped 65 different human cell types and half of the 2,600 enzymes that are known drug targets in order to produce the network model.

Co-author Douglas Kell, Chief Executive of Biotechnology and Biological Sciences Research Council (BBSRC) and Professor of Bioanalytical Science at the Manchester Institute of Biotechnology, said: "To understand the behaviour of a system one must have a model of it. By converting our biological knowledge into a mathematical model format, this work provides a freely accessible tool that will offer an in-depth understanding of human metabolism and its key role in many major human diseases.

"This study offers the most complete model of the human metabolic network available to date to help analyse and test predictions about the physiological and biochemical properties of human cells."

Dr Nicolas Le Novère, from the Babraham Institute said: "This is a model that links the smallest molecular scale to the full cellular level. It contains more than 8,000 molecular species and 7,000 chemical reactions - no single researcher could have built this alone. Having large collaborations like these, using open standards and data-sharing resources, is crucial for systems biology."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

A New £81.6M Food and Health Research Centre
The Quadram Institute is the name of the new centre for food and health research to be located at the heart of the Norwich Research Park, one of Europe’s largest single-site concentrations of research in food, health and environmental sciences.
Wednesday, February 17, 2016
Genome-Editing Position Statement
A group of leading UK research organisations has today issued an initial joint statement in support of the continued use of CRISPR-Cas9 and other genome-editing techniques in preclinical research.
Monday, September 07, 2015
Expanding the DNA Alphabet: 'Extra' DNA Base Found to be Stable in Mammals
A rare DNA base, previously thought to be a temporary modification, has been shown to be stable in mammalian DNA, suggesting that it plays a key role in cellular function.
Thursday, June 25, 2015
Global Food Security (GFS) Develops New Funding Programme
New programme of research to tackle resilience of the food system.
Tuesday, June 02, 2015
£4M to Fund Important Food Crops from BBSRC and NERC
Research projects designed with industry partners to maximize impact.
Tuesday, June 02, 2015
Controlling Leaf Blotch Disease In Wheat
Scientists have found a genetic mechanism that could stop the spread of a "devastating" disease threatening wheat crops.
Thursday, February 05, 2015
Rising Temperatures Predicted to Lower Wheat Yields
An international consortium of researchers has used big data sets to predict the effects climate change on global wheat yields.
Friday, December 26, 2014
New Test For Detecting Horse Meat
New test compares differences in chemical compositions of the fat found in meats.
Tuesday, December 02, 2014
UK And India Collaborate On Future-Proof Crops
Drought-tolerant tomatoes, improved wheat and grass pea could provide crops for the future.
Friday, November 28, 2014
Drugs Used to Treat Lung Disease Work With the Body Clock
Scientists from The University of Manchester have discovered why medication to treat asthma and pneumonia can become ineffective.
Thursday, August 14, 2014
Researchers Use ‘Big Data’ Approach to Map the Relationships Between Human and Animal Diseases
EID2 database used to prevent and tackle disease outbreaks around the globe.
Thursday, July 17, 2014
TGAC at the Forefront of Next Generation Sequencing Capability
The Genome Analysis Centre adds two Illumina HiSeq 2500 machines to its platform suite.
Thursday, June 26, 2014
UK Diet and Health Research Awarded £4M
Funding awarded to six projects investigating diet and health to enable the food and drink industry to meet the needs of UK consumers.
Wednesday, June 25, 2014
Better Understanding of Disease Resistance Genes in Crops
Effector-triggered defence concept describes how plants protect themselves against the apoplast.
Friday, June 06, 2014
Investment Provides Access to the World’s Most Advanced Crystallography Technology
The UK community will benefit thanks to a £5.64M investment from UK research funders.
Tuesday, June 03, 2014
Scientific News
Computational Model Finds New Protein-Protein Interactions
Researchers at University of Pittsburgh have discovered 500 new protein-protein interactions (PPIs) associated with genes linked to schizophrenia.
Experimental Drug Cancels Effect from Key Intellectual Disability Gene
A University of Wisconsin—Madison researcher who studies the most common genetic intellectual disability has used an experimental drug to reverse — in mice — damage from the mutation that causes the syndrome.
MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment
Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Bioreactors Ready for the Big Time
Bioreactors are passive filtration systems that can reduce nitrate losses from farm fields.
Analysis of Dog Genome will Provide Insight into Human Disease
An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies – according to a new study led by The Genome Analysis Centre (TGAC).
‘Mini-Brains’ to Study Zika
Novel tool expected to speed research on brain and drug development.
Finding Factors That Protect Against Flu
A clinical trial examining the body’s response to seasonal flu suggests new approaches for evaluating the effectiveness of seasonal flu vaccines.
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Controlling RNA in Living Cells
Modular, programmable proteins can be used to track or manipulate gene expression.
Common Class of Cancer Drugs May Not Lead to Cognitive Decline
UCLA study refutes 2015 research suggesting anthracyclines could cause memory loss, other impairments.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!