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Biosearch Technologies Licenses RNA FISH-based Inventions from UMDNJ

Published: Tuesday, March 19, 2013
Last Updated: Tuesday, March 19, 2013
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Stellaris® Probe alliance - NextGen Gene Expression™, SNP FISH™, and iceFISH™ in research and clinical applications.

Biosearch Technologies, Inc. (Biosearch) announced that the company has acquired exclusive worldwide rights to continuing Stellaris® RNA FISH based inventions from the University of Medicine and Dentistry of New Jersey (UMDNJ). In addition to single molecule detection of mRNA, lncRNA, and viral RNAs, Stellaris based methods have been extended to directly and quantitatively detect chromosomal diseases caused by translocations and aberrant splice junctions,(intron chromosomal expression – iceFISH™) and single-nucleotide polymorphisms (SNPs or SNP FISH™). Biosearch’s exclusive access to Stellaris probe design is offered complimentary at

“Stellaris Next-Gen gene expression methods deliver high-content analysis within cells and tissues, along with single-molecule detection and quantitation. While qPCR delivers only an average number of RNA transcripts across a population of cells and tissues, and depends on a series of events, including isolation, extraction, purification, amplification and probe analysis, Stellaris RNA FISH delivers directly detected ‘Seeing is Believing’ satisfaction, that eliminates the multiple qPCR processing complexities, costs and blind eye analysis”, says Marc Beal, Director of Corporate Development at Biosearch. “In addition, for the first time, and in the same reaction, researchers and clinicians can simultaneously perform gene expression and chromosomal analysis in combination with Immunofluorescence (IF, IHC). This unique property of Stellaris probes enables transactional analysis from transcription through translation at the single-cell and single-molecule level.”

“Chromosomal paints are just the latest in a series of continuing developments of Stellaris-based tools”, says Arjun Raj, co-inventor of the Stellaris based RNA FISH technology. “We believe our chromosomal paints will provide a simple and effective method for visualizing chromosome structure while simultaneously detecting mRNA levels in single cells. Furthermore, we are very excited to be developing new Stellaris-based assays for long non-coding RNA, allowing us to peer into the ‘dark matter’ of the genome. We are also working on a number of exciting new tools based on the use of Stellaris in the lab, and we are very excited about working with Biosearch to bring these methods to the market. These include assays for live cell imaging.”

"The single-molecule sensitivity afforded by Stellaris probes is providing unprecedented insights into diverse biological processes ranging from RNA localization, RNA processing, the assessment of noise in gene expression. The availability of pre-labeled sets of probes from Biosearch is a tremendous help to cell biologists who no longer need to be concerned with the complexities of probe selection and probe chemistry,” says Sanjay Tyagi, co-inventor of Stellaris based RNA FISH technology.

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