Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researchers Pair Experiments with Computer Models to Peer into Cells

Published: Wednesday, March 20, 2013
Last Updated: Wednesday, March 20, 2013
Bookmark and Share
BBSRC-funded researchers have developed a new strategy that can give scientists a better insight into how complex molecular machineries function in living cells.

In research published in the journal Molecular Systems Biology, the team from the University of Warwick, Manchester Interdisciplinary Biocentre and Liverpool University showed how to extract in vivo information about how complex molecular systems in yeast cells are controlled.

By making small changes in a process called mRNA translation, a crucial step in the manufacture of proteins within a cell, the team was able to obtain important information without disrupting the system.

These data were used to set parameters for a detailed computational model of protein synthesis in cells, revealing a number of insights about the process which were previously unknown.

For example, the research showed how individual components in the mRNA translation process had co-evolved to share responsibility for controlling how fast proteins are made.

Professor John McCarthy, professor of molecular systems biology at Warwick University, said: "A major objective of systems biology is to move forward from analysis of individual cellular components to create accurate digital models that provide insight into how these components work together within living cells.

"Through this approach, we ultimately hope to understand the 'emergent properties' of molecular systems in cells that, for decades, have fascinated biologists but evaded proper explanation.

"Up to now, it has proved very difficult to obtain an accurate picture of how cells control the various processes that go on inside them, leaving us largely guessing how the properties of individual components relate to the behaviour of systems that are assembled from them within living cells.

"Using minimal perturbations of precisely targeted steps of specific cellular processes together with a large number of quantitative analytical measurements, we have now made a major first step towards obtaining detailed insight into how the living cell's protein synthesis machinery is managed at the system level."

The approach has potential as a platform for a wide range of future studies into the molecular systems biology of gene expression.

The researchers also believe the combined experimental and computational approach taken should be applicable to multiple processes in a range of organisms.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

£9M Funding to Optimise UK Food Supply
Five research prjects have been awarded a portion of £9M to help increase resilience in UK food systems.
Wednesday, August 31, 2016
£4.5M Newton Fund to Tackle Antimicrobial Resistance
Six research partnerships tackling the rise of anti-microbial resistance (AMR) have been created with £4.5M investment by the UK Research Councils.
Wednesday, August 31, 2016
Major Pathogen of Barley Decoded
A team of scientists studying the fungus that causes Ramularia leaf spot have sequenced and explored its genome.
Wednesday, August 31, 2016
UK-Brazil Wheat Research Projects Awarded £4M
£4M investment from BBSRC and Embrapa has been awarded to four Brazil-UK partnerships.
Wednesday, July 27, 2016
Protein Boosts Rice Yield by 54%
Over-expression of a natural protein in rice plants led to a 54% increase in crop yield and 40% increase in nitrogen-use efficiency.
Wednesday, July 27, 2016
A New £81.6M Food and Health Research Centre
The Quadram Institute is the name of the new centre for food and health research to be located at the heart of the Norwich Research Park, one of Europe’s largest single-site concentrations of research in food, health and environmental sciences.
Wednesday, February 17, 2016
Genome-Editing Position Statement
A group of leading UK research organisations has today issued an initial joint statement in support of the continued use of CRISPR-Cas9 and other genome-editing techniques in preclinical research.
Monday, September 07, 2015
Expanding the DNA Alphabet: 'Extra' DNA Base Found to be Stable in Mammals
A rare DNA base, previously thought to be a temporary modification, has been shown to be stable in mammalian DNA, suggesting that it plays a key role in cellular function.
Thursday, June 25, 2015
Global Food Security (GFS) Develops New Funding Programme
New programme of research to tackle resilience of the food system.
Tuesday, June 02, 2015
£4M to Fund Important Food Crops from BBSRC and NERC
Research projects designed with industry partners to maximize impact.
Tuesday, June 02, 2015
Controlling Leaf Blotch Disease In Wheat
Scientists have found a genetic mechanism that could stop the spread of a "devastating" disease threatening wheat crops.
Thursday, February 05, 2015
Rising Temperatures Predicted to Lower Wheat Yields
An international consortium of researchers has used big data sets to predict the effects climate change on global wheat yields.
Friday, December 26, 2014
New Test For Detecting Horse Meat
New test compares differences in chemical compositions of the fat found in meats.
Tuesday, December 02, 2014
UK And India Collaborate On Future-Proof Crops
Drought-tolerant tomatoes, improved wheat and grass pea could provide crops for the future.
Friday, November 28, 2014
Drugs Used to Treat Lung Disease Work With the Body Clock
Scientists from The University of Manchester have discovered why medication to treat asthma and pneumonia can become ineffective.
Thursday, August 14, 2014
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients
The research could be a key step in developing treatments to eliminate symptoms that drastically impair the quality of life in Rett patients.
Heart Arrhythmia Caused by Mosaic of Mutant Cells
Researchers have solved the genetic mystery of an infant suffering from heart arrhythmia.
Iron Nanoparticles Make Immune Cells Attack Cancer
Researchers accidentally discover that nanoparticles invented for anemia treatment can trigger the immune system’s ability to destroy tumor cells.
Crispr Toolbox Expanded By Protein
Researchers have shown a newly discovered CRISPR protein has two distinct RNA cutting activities.
Atmosphere Acidity Minimised to Preindustrial Levels
Sheet ice study shows acidic pollution of the atmosphere has now almost returned to preindustrial levels.
New Therapeutic Target for Crohn’s Disease
A promising new target for drugs that treat IBD has been identified along with a possible biomarker for IBD severity.
Culex Mosquitoes Do Not Transmit Zika
A study of the Culex species mosquito appears to show that the species does not transmit Zika virus.
Uncovering Water Bear Resilience
A protein identified in water bears can protect DNA of human cells from lethal doses of radiation damage.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!