Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Fibrocell/UCLA Study on Human Skin Cells Yields Promising Results

Published: Thursday, March 21, 2013
Last Updated: Thursday, March 21, 2013
Bookmark and Share
Research has resulted in a discovery that may lead to a more predictable, commercially viable method of producing stable, induced pluripotent stem (iPS) cells from adult skin cells.

The study has been accepted for publication in the Stem Cell Research and Therapy peer-reviewed journal and the provisional paper is available online. It was conducted under the guidance of James Byrne, PhD, assistant professor, UCLA Department of Molecular and Medical Pharmacology, at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research.

“We continue to be pleased with the results of our collaboration with UCLA to pursue the full potential of fibroblasts,” said David Pernock, CEO and Board Chair, Fibrocell Science.

The cells may be used by academic researchers and pharmaceutical companies to evaluate new drug compounds for safety and to develop patient-specific therapies for multiple disease states, including heart disease, Parkinson’s disease and diabetes. Using skin cells is more advantageous to the patient than obtaining cells from bone marrow or adipose tissue (fat). A skin biopsy is quicker to perform, less painful and minimally invasive.

Dr. Byrne’s study found human skin cells cultured in the presence of a chemical known as BAY11 resulted in reproducible increased expression of the OCT4 gene that did not inhibit normal cell growth. OCT4 is involved in many cell processes, but is primarily known to maintain pluripotency and regulate cell differentiation. It is typically used as a marker to identify undifferentiated cells.

The development of a more stable method to create iPS cells from skin cells allows for the potential of a reproducible commercial manufacturing process. The study was performed at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Department of Molecular and Medical Pharmacology at UCLA in conjunction with the Department of Cell Biology and Neuroscience at Rutgers University.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
Investigating the Vape
Expert independent review concludes that e-cigarettes have potential to help smokers quit.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Researchers Discover Synthesis of a New Nanomaterial
Interdisciplinary team creates biocomposite for first time using physiological conditions.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!