Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

In Managing Inflammation, Controlling White Blood Cell Flow may be Key

Published: Wednesday, March 27, 2013
Last Updated: Wednesday, March 27, 2013
Bookmark and Share
New research by sets the stage for improved management of acute tissue inflammation by advancing current understanding of inflammatory processes.

To exit blood vessels and reach injured tissue, white blood cells must pass through a series of natural barriers. Some aspects of blood vessel architecture facilitate white cell migration to a greater degree than others, a means of self-regulation: Excessive migration can result in extreme inflammation, turning otherwise helpful white cells into agents of disease.

Research by Yale bioengineers reported March 26 in the journal PLOS ONE sheds new light on the roles of specific layers of vasculature, suggesting ways of controlling inflammation.

“By understanding the regulatory mechanisms within the vascular wall, we hope we can identify potential treatments to ensure or restore the balance between protection and destruction of tissues,” said Anjelica L. Gonzalez, assistant professor of biomedical engineering at Yale and principal investigator of the research.

The work focuses in particular on the function of a less permeable (and little studied, researchers said) layer of cells within the blood vessel wall known as the pericyte layer.

Using a composite microvascular model that incorporates both the inner and outer layers of blood vessels, Gonzalez and colleagues showed that the outer pericyte layer helps restrict the number of exiting white blood cells. This helps prevent excessive inflammation, they said. In contrast, the inner (endothelial) layer primes white blood cells for passage through the pericyte layer by transforming them into a more versatile cell subpopulation. A malfunctioning pericyte layer could be responsible for excessive inflammation, they said.

“The results suggest that any disease or disorder that can be termed inflammatory — including wound healing, tissue fibrosis and cancer metastasis — may be exacerbated because of a poor pericyte barrier,” said Gonzalez. “White blood cell-mediated inflammation, in particular, is related to the progression of many inflammatory disorders. These findings give us targets on the white blood cell that will allow us to develop therapeutics aimed at inhibiting their contribution to disease progression.”

The paper’s lead author is Chantal E. Ayres-Sander. Co-authors are Holly Lauridsen, Cheryl L. Maier, Parid Sava, and Jordan S. Pober.

The Hartwell Foundation, a Dubinsky New Initiatives Award, and the National Institutes of Health provided support for the research.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Effects Of Maternal Smoking Continue Long After Birth
Yale study shows that maternal smoking is linked to behavioural changes.
Wednesday, June 01, 2016
Reduced Immune Response Causes Flu Deaths in Older Adults
Yale study suggests that immune response to flu causes death in older people, not the virus.
Friday, April 22, 2016
CNS Inflammation: A Pathway and Possible Drug Target
Scientists have long known that the central nervous system (CNS) has a remarkable ability to limit excessive inflammation in the presence of antigens or injury, but how it works has been unclear.
Tuesday, April 12, 2016
Nanogel That Delivers One-Two Punch To Cancer Heads To Clinical Trial
Yale scientists create a nanogel which can be used to deliver multiple drugs to cancer cells.
Wednesday, April 06, 2016
Chaos, Hope, And The Lupus Butterfly Theory
The lupus butterfly theory suggests that antibodies that attack DNA in lupus may be sources of both chaos and hope.
Wednesday, April 06, 2016
Life-Extending Hormone Bolsters Immunity
A hormone that extends lifespan in mice by 40% is produced by specialized cells in the thymus gland, according to a new study by Yale School of Medicine researchers.
Wednesday, January 13, 2016
Novel Technique for Kidney Research Developed
To better understand how the treatment leads to kidney damage, and possibly prevent it, a team of researchers at Yale School of Medicine developed a new 3D-imaging technique to peer deep into these vital organs.
Thursday, August 27, 2015
Shedding Light On Century-Old Biochemical Mystery
Yale scientists have used magnetic resonance measurements to show how glucose is metabolized in yeast to answer the puzzle of the “Warburg Effect.”
Thursday, August 20, 2015
Gene Testing Now Allows Precision Medicine for Thoracic Aneurysms
Researchers at the Aortic Institute at Yale have tested the genomes of more than 100 patients with thoracic aortic aneurysms, a potentially lethal condition, and provided genetically personalized care.
Monday, July 20, 2015
Creating More Potent Vaccines
Yale researchers uncovered a new role for a type of immune cell, known as regulatory T cells, in promoting long-term immunity.
Wednesday, July 08, 2015
Yale Team finds why BRCA Gene Resists Cancer Treatment
The University researchers have discovered why a key molecular assistant is crucial to the function of the BRCA2 gene.
Tuesday, July 07, 2015
New Type of Drug Can Target All Disease-causing Proteins
Current drugs block the actions of only about a quarter of known disease-causing proteins, but Yale University researchers have developed a technology capable of not just inhibiting, but destroying every protein it targets.
Monday, June 15, 2015
After a Sip of Milkshake, Genes and Brain Activity Predict Weight Gain
The new study published in The Journal Neuroscience.
Thursday, May 21, 2015
Researchers Solve Multiple Sclerosis Puzzle
Yale study shows the role that T cells play in MS.
Monday, May 18, 2015
Gene Editing Corrects Mutation In Cystic Fibrosis
Yale researchers successfully corrected the most common mutation in the gene that causes cystic fibrosis, a lethal genetic disorder.
Monday, April 27, 2015
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Flu Vaccine May Reduce Risk of Death For Type 2 Diabetes Patients
Researchers at Imperial College London have suggested that the vaccine may have substantial benefits for patients with long-term conditions.
Cancer Gene-Drug Combinations Ripe for Precision Medicine
The study aims to expand the number of cancer gene mutations that can be paired with a precision therapy.
Porphyrins as Catalysts in Scalable Organic Reactions
This review covers the most relevant scalable porphyrin-catalysed procedures, showing how these compounds represent broad applications in chemistry.
CDC Updates Zika Recommendations
CDC has issued updated Zika recommendations and guidance for healthcare providers with a focus on sexual transmission.
Exploiting Malaria’s Achilles’ Heel
Researchers have uncovered an Achilles' heel in malaria's anti-drug treatment arsenal that could lead to a disease cure.
Genome of 6000-Year-Old Barley Sequenced
Researchers have successfully sequenced the genome of Chalcolithic barley grains for the first time.
3D Models May Yield Ovarian Cancer Insights
Researchers are developing new tools to decipher ovarian cancer developments through a 3D printing technology.
Targeting BRAF Mutations in Thyroid Cancer
Treating metastatic thyroid cancer patients harboring a BRAF mutation with vemurafenib showed anti-tumor activity in a third of patients.
Plant Compounds Fight Together Against Colon Cancer
Research shows treating colon cancer cells with curcumin, then silymarin is more effective than treatment with each individually.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!