Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Foot-and-Mouth Vaccine is Safer and Cheaper to Produce

Published: Thursday, March 28, 2013
Last Updated: Thursday, March 28, 2013
Bookmark and Share
A new vaccine against foot-and-mouth disease that is safer to produce and easier to store has been developed by scientists from the University of Oxford and The Pirbright Institute.

They have used a new method to produce a vaccine that doesn't rely on inactivating the live, infectious virus which causes the disease – and is therefore much safer to produce.

Instead the vaccine consists of empty virus shells that have been produced synthetically, and are designed to produce an immune response that protects against the disease.

Furthermore, the empty shells have been engineered to be more stable, making the vaccine much easier to store because the need for the vaccine to be refrigerated is reduced.

The 2001 foot and mouth outbreak in Britain was devastating and cost the economy billions of pounds in control measures and compensation. One recommendation in a Royal Society report following the epidemic recommended the development of new approaches to control the virus.

An improved vaccine against the disease would also be important in countries where the disease is endemic, which are often in the developing world.

The research was led by Professor David Stuart, professor of structural biology at the University of Oxford and life science director at Diamond Light Source, and Dr Bryan Charleston of The Pirbright Institute. The findings are published in the journal PLOS Pathogens.

'What we have achieved here is close to the holy grail of foot-and-mouth vaccines. Unlike the traditional vaccines, there is no chance that the empty shell vaccine could revert to an infectious form,' says Professor Stuart.

Dr Charleston adds: 'The ability to produce a vaccine outside of high containment and that does not require a cold storage chain should greatly increase production capacity and reduce costs. Globally there is an undersupply of the vaccine due to the high cost of production and this new development could solve this problem and significantly control foot-and-mouth disease worldwide.'

Early clinical trials of the new vaccine in cattle have shown it is as effective as current vaccines. Whilst a commercial product is still several years away, the team hopes that the technology can be transferred as quickly as possible to make it available to a global market.

One of the problems of existing vaccines against foot and mouth disease is identifying which animals have been vaccinated and which haven't.

Dr Charleston says: 'The complete absence of some viral proteins from this new vaccine will also allow companion diagnostic tests to be further refined to demonstrate the absence of infection in vaccinated animals with greater confidence.'

The work on the structure of the virus shells and identification of mutations to improve their stability was carried out by Professor David Stuart and his team at Oxford University using Diamond Light Source, the UK's national synchrotron facility.

Dr Bryan Charleston at Pirbright Institute and Professor Ian Jones at Reading University and their teams incorporated the mutations into the empty virus shells and showed they stimulate protective immunity in cattle.

Together the three groups have developed a system for the production of empty protein shells in commercially viable amounts.

Richard Seabrook, Head of Business Development at the Wellcome Trust, which part-funded the work, says: 'This vaccine still has some way to go before it will be available to farmers but these early results are very encouraging.'

Nigel Gibbens, the UK's Chief Veterinary Officer, comments: 'There are many more years of work and research to be done to get this vaccine ready for use, but this is undoubtedly an exciting leap forward. Once available, vaccines of this type would have clear advantages over current technology as a possible option to help control the disease should we ever have another foot and mouth disease outbreak.

'This vaccine has been developed using some truly groundbreaking techniques which are a credit to the quality of British scientists working in the field of animal health.'

The scientists involved believe this new approach to making and stabilising a vaccine may also work with other viruses from the same family, including viruses that infect humans such as polio.

'This work will have a broad and enduring impact on vaccine development, and the technology should be transferable to other viruses from the same family, such as poliovirus and hand foot and mouth disease, a human virus which is currently endemic in south-east Asia,' says Professor Stuart.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genetic Research Can Significantly Improve Drug Development
With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?
Friday, June 17, 2016
Genes That Increase Children's Risk Of Blood Infection Identified
A team led by Oxford University has identified genes that make certain children more susceptible to invasive bacterial infections by performing a large genome-wide association study in African children.
Friday, May 27, 2016
Universal Flu Vaccine Under Development
Oxford spinout company Vaccitech has been launched with £10m seed investment to develop a universal flu vaccine already showing promise in clinical trials.
Friday, May 13, 2016
Biomarker Discovery Offers Hope For New TB Vaccine
A team of scientists led by Oxford University have made a discovery that could improve our chances of developing an effective vaccine against Tuberculosis.
Tuesday, April 12, 2016
Novel Collagen Fingerprinting Identifies A Neanderthal
Study from the universities of Oxford and Manchester uses ZooMS technique to identify traces of an extinct human.
Friday, April 01, 2016
Origin of a Species
A study by researchers at the Wellcome Trust Centre for Human Genetics at Oxford University has uncovered the key role played by a single gene in how groups of animals diverge to form new species.
Monday, February 15, 2016
HIV Keeps Growing, Even When Undetectable
A team of international researchers including scientists from Oxford University has found that HIV is still replicating in lymphoid tissue even when it is undetectable in the blood of patients on antiretroviral drugs.
Friday, January 29, 2016
Bacterial Superglue for Faster Vaccine Development
An interdisciplinary team of Oxford University researchers has devised a new technique to speed up the development of novel vaccines.
Wednesday, January 20, 2016
Millions at Risk of Little Known Deadly Tropical Disease
Melioidosis, a difficult to diagnose deadly bacterial disease, is likely to be present in many more countries than previously thought.
Tuesday, January 12, 2016
Identifying Drug Resistance Traits
Scientists have developed an easy-to-use computer program that can quickly analyse bacterial DNA from a patient's infection and predict which antibiotics will work, and which will fail due to drug resistance.
Tuesday, December 22, 2015
Faster, Cheaper TB Diagnosis
Whole Genome Sequencing is a faster, cheaper and more effective way of diagnosing tuberculosis says a new study.
Wednesday, December 09, 2015
Why we Still Don’t Have Personalised Medicine
15 years after sequencing the human genome we still do not have the promised personalised medicine, why is this?
Friday, December 04, 2015
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Tuesday, November 24, 2015
Seeking the Right Prescription in Fight Against Antibiotic Resistance
Researchers at the University of Oxford have received funding to look at ways to improve the prescribing of antibiotics.
Monday, November 23, 2015
£17M Project Launched to Develop HIV Vaccine
A new €23 million (£17 million) initiative to accelerate the search for an effective HIV vaccine has begun.
Wednesday, November 11, 2015
Scientific News
Platelets are the Pathfinders for Leukocyte Extravasation During Inflammation
Findings from the study could help in the prevention and treatment of inflammatory pathologies.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Manufactured Stem Cells to Advance Clinical Research
Clinical-grade cell line will enable development of new therapies and accelerate early-stage clinical research.
Dengue Virus Exposure May Amplify Zika Infection
Researchers at Imperial College London have found that the previous exposure to the dengue virus may increase the potency of Zika infection.
Gender Determination in Forensic Investigations
This study investigated the effectiveness of lip print analysis as a tool in gender determination.
Identifying Novel Types of Forensic Markers in Degraded DNA
Scientists have tried to verify the nucleosome protection hypothesis by discovering STRs within nucleosome core regions, using whole genome sequencing.
Proteins in Blood of Heart Disease Patients May Predict Adverse Events
Nine-protein test shown superior to conventional assessments of risk.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Starving Stem Cells May Enable Scientists To Build Better Blood Vessels
Researchers from the University of Illinois at Chicago College of Medicine have uncovered how changes in metabolism of human embryonic stem cells help coax them to mature into specific cell types — and may improve their function in engineered organs or tissues.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!