Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Genedata Enables Research to Improve Personalized Treatment of Breast and Ovarian Cancer

Published: Saturday, April 06, 2013
Last Updated: Friday, April 05, 2013
Bookmark and Share
Genedata collaborates with leading European institutions on the development of blood tests for early detection of major female cancers based on epigenetic markers

Genedata, a leading provider of advanced software solutions for drug discovery and life science research, today announced its partnership with EpiFemCare, the EU-funded research project that will improve the diagnosis and therapy of breast and ovarian cancer. Genedata scientists will manage, process and analyze terabytes of epigenetic and clinical data from next-generation sequencing, microarray and qPCR experiments to help identify, confirm and clinically validate biomarkers. These should lead to significant improvements in early cancer detection and subsequent patient care. The project will also use Genedata Expressionist®, the leading data analysis and management platform for oncology research.

One of the project's research challenges is the management of complex and large datasets produced by next-generation technologies (e.g. like sequencing, Illumina Infinium arrays and digital qPCR). Genedata scientists will use Genedata Expressionist to identify the most relevant DNA methylation sites, within tens of terabytes of data, which can accurately diagnose breast and ovarian cancer. Resulting biomarkers will be confirmed by independent sample sets and finally validated in large clinical cohorts with over 200,000 patient samples from which over 7,000 will be tested. Genedata Expressionist will be used for its intuitive data visualization, rigorous statistical algorithms, innovative biological interpretation and efficient management and integration of data from various sources and different technology platforms.
"Currently, many women face a diagnosis of advanced ovarian cancer or breast cancer over-diagnosis due to lack of suitable early-detection tests and over-zealous screening procedures," noted Professor Dr. Martin Widschwendter, the EpiFemCare project coordinator, from the Department of Women's Cancer at the University College London "We look forward to collaborating with Genedata and using their epigenetics and oncology expertise to develop innovative blood-based tests with increased sensitivity to ovarian cancers and increased specificity for breast cancers."

Innovative and collaborative, the EpiFemCare project is partially funded by the European Union Seventh Framework Programme for Research and Innovation (FP7). In addition to Genedata, project collaborators include: Charles University (Prague, Czech Republic); Ludwig Maximilian University (Munich, Germany); EURAM Ltd (Nottingham, United Kingdom); and GATC Biotech (Konstanz, Germany). EpiFemCare research aims to reduce by 50% the number of women who receive a diagnosis of breast or ovarian cancer when that cancer is already advanced, reduce by 50% the number of women who receive unnecessary long-term chemotherapy, and reduce the number of women dying from these female cancers by 20%.

"The EpiFemCare project is tackling the next frontier in the fight against breast and ovarian cancers -- to facilitate early detection of disease and better prediction of therapeutic outcomes -- and we are eager to contribute our epigenetics know-how to EpiFemCare's success," said Dr. Othmar Pfannes, CEO of Genedata. "We hope our experience and expertise in the management and analysis of complex datasets in the context of epigenetics and oncology research will help improve methods for screening, diagnosing and personalizing treatment of breast and ovarian cancers."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genedata Signs License Agreement with AstraZeneca
Genedata Screener now AstraZeneca’s corporate platform for expediting drug discovery.
Saturday, November 21, 2015
Kymab Implements Genedata Biologics for High-throughput Antibody Discovery
Genedata Biologics™ integrated workflow platform used to increase throughput and automation of Kymab’s transgenic mice-based discovery platforms.
Tuesday, November 17, 2015
Genedata Completes Important Milestone in Collaboration with Bayer Pharma AG
Successful integration of Genedata Profiler™ allows researchers to access, process, analyze and manage petabytes of NGS and other omics data from patients and pre-clinical experiments.
Thursday, September 24, 2015
Merck Serono Chooses Genedata Biologics to Streamline Antibody Discovery Processes
Global deployment of Genedata Biologics across multiple protein therapeutics R&D groups to standardize workflows and improve efficiency.
Thursday, July 23, 2015
Genedata Releases a Breakthrough for Genomic Comparison
Genedata Selector™4.0 provides reference-independent genome sequence comparisons while reducing data processing and analysis time to optimize efficiency and save costs.
Wednesday, July 22, 2015
Genedata Forges Alliance with Intellicyt
Swiss informatics firm Genedata and Intellicyt today announced an alliance to work on cell-based screening in drug discovery.
Thursday, June 18, 2015
Precision Medicine Software Genedata Profiler™ Launched at Bio-IT World
Open, interoperable enterprise platform for patient and compound profiling provides important data management infrastructure for pharma internal R&D processes.
Friday, April 24, 2015
Partner on Innovative Workflow Platform for High-Throughput Cell Line Development
Novel Cell Line Development (CLD) data platform to support the generation and assessment of mammalian production cell lines.
Tuesday, March 17, 2015
Genedata, Bayer Pharma AG Partner on Innovative Workflow Platform for High-Throughput Cell Line Development
Novel Cell Line Development (CLD) data platform to support the generation and assessment of mammalian production cell lines.
Tuesday, March 17, 2015
Genedata Biologics Licensed by Pfizer
Pfizer implements Genedata Biologics to streamline global biopharma R&D processes.
Wednesday, March 04, 2015
Boehringer Ingelheim Selects Genedata Biologics as Antibody Discovery Workflow Platform
Genedata Biologics integrates and streamlines workflows for protein therapeutics R&D groups across multiple Boehringer Ingelheim sites.
Thursday, February 19, 2015
Genedata Highlights Combination Screening and Surface Plasmon Resonance at SLAS 2015
Colloquium and tutorials on Combination Screening and SPR examine Genedata Screener as the platform for all plate-based screening experiments.
Wednesday, February 04, 2015
Takara Bio Selects Genedata Software to Automate and Standardize NGS Data Analysis
Genedata Expressionist® for Genomic Profiling helps Takara Bio to manage, process, and analyze large NGS datasets.
Wednesday, November 05, 2014
Exploring Innovations in SPR & Combination Screening
Genedata customers will discuss innovations in high content imaging, high throughput screening, compound combination screening, and other related topics at User Group Meetings.
Tuesday, August 26, 2014
GSK Implements Genedata Biologics as Antibody Discovery Platform
Genedata Biologics integrates GlaxoSmithKline's Biopharm Discovery workflows across multiple Biopharm R&D groups and sites
Thursday, June 12, 2014
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos