Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Immune Response Linked to Key Enzyme

Published: Friday, April 12, 2013
Last Updated: Friday, April 12, 2013
Bookmark and Share
A family of enzymes may contribute to scientists’ understanding of signaling molecules involved in the body’s immune response.

The family of enzymes, called Sir2, has been extensively studied for their role in aging.

The research, published April 4 in the journal Nature, was led by senior author Hening Lin, associate professor of chemistry and chemical biology. Lin and colleagues reported that the enzyme Sirtuin-6 (SIRT6) promotes the secretion of a signaling molecule called tumor necrosis factor-alpha (TNF), which is important for triggering immune responses in mammalian cells.

Rheumatoid arthritis, for example, is associated with is an overabundance of TNF. The molecule also promotes cancer cell death. The study found that SIRT6 promotes TNF secretion by removing long-chain fatty acyl groups from protein lysine residues.

It was not previously known that SIRT6 could play this key chemical role in the TNF promotion process. Based on the findings, researchers may one day look to manipulate SIRT6 in therapies to treat diseases.

This is the first study to explain how such long-chain fatty acyl groups are removed in mammalian cells.

“This long-chain fatty acyl lysine modification was reported 30 years ago, but no one knew its physiological function, so our finding helps explain that,” Lin said.

The study was funded in part by the National Institutes of Health. Co-authors include researchers from the University of Hong Kong, Rockefeller University and Harvard Medical School. The study’s lead authors were Hong Jiang, research associate, Saba Khan, graduate student, both in Lin’s lab, and Yi Wang, a researcher at the University of Hong Kong.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More Than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Cancer Cells 'Talk' to their Environment, and it Talks Back
Scientists from Cornell University have developed a novel microscopy technique to measure the force breast cancer cells exert on their surroundings.
Wednesday, November 23, 2016
Wicked Weeds May Be Agricultural Angels
Agricutural scientists suggest less control over nature, as weeds can be beneficial to agriculture.
Wednesday, November 16, 2016
Bad Mitochondrial DNA May Increase Risk of Autism in Kids
Researchers have confired a genetic link between mtDNA and certain forms of autism spectrum disorder.
Tuesday, November 01, 2016
C Dots Show Powerful Tumor Killing Effect
Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer.
Friday, September 30, 2016
$1M NIH Grant to Refine PCR Based Cancer Test
Researchers at Cornell University, Weill Cornell Medicine, the University of California, San Francisco, and the Infectious Diseases Institute in Kampala, Uganda, recieve a four-year, $1 million grant to hone technology for a quick, in-the-field diagnosis of Kaposi's sarcoma — a cancer frequently related to HIV infections.
Friday, September 02, 2016
Vortex Ring Freezing Applications
Accidental lab discovery could aid cell delivery and cell-free protein production.
Monday, August 22, 2016
Measuring Chemistry on a Chip
Researchers developing chemical sensor chip for sample analysis in a lab or monitoring air and water quality in the field.
Thursday, August 18, 2016
Key to Chronic Fatigue Syndrome is in Your Gut, Not Head
Researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.
Wednesday, June 29, 2016
Pathogen Takes Control of Gypsy Moth Populations
A new fungal pathogen is killing gypsy moth caterpillars and crowding out communities of pathogens and parasites that previously destroyed these moth pests.
Tuesday, April 26, 2016
Eating Green Could be in Your Genes
Genetic variation uncovered that has evolved in populations that have historically favored vegetarian diets, such as in India, Africa and parts of East Asia.
Friday, April 01, 2016
$4.8M USAID Grant to Improve Food Security
To strengthen capacity to develop and disseminate genetically engineered eggplant in Bangladesh and the Philippines, the USAID has awarded Cornell a $4.8 million, three-year cooperative grant.
Friday, April 01, 2016
Proteins Seek, Attack, Destroy Tumor Cells in Bloodstream
Using white blood cells to ferry potent cancer-killing proteins through the bloodstream virtually eliminates metastatic prostate cancer in mice, Cornell researchers have confirmed.
Friday, January 15, 2016
Tumor-suppressing Gene Lends Insight to Cancer Treatment
Researchers have found that delicate replication process derails if a gene named PTEN has mutated or is absent.
Tuesday, July 14, 2015
Synthetic Immune Organ Produces Antibodies
Cornell engineers have created a functional, synthetic immune organ that produces antibodies and can be controlled in the lab, completely separate from a living organism.
Friday, June 12, 2015
On Planes, Savory Tomato Becomes Favored Flavor
Study shows the effect that airplane noise has on passengers' taste preferences.
Friday, May 15, 2015
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.
Unique Visual Stimulation May Be New Treatment for Alzheimer’s
Noninvasive technique reduces beta amyloid plaques in mouse models of Alzheimer’s disease.
Major Neuroscience Initiative Launched
Tianqiao and Chrissy Chen Institute invest $115 million to further expand neuroscience research, while Caltech construct $200 million biosciences complex.
Making It Personal
Cancer vaccine linked to increased immune response against leukemia cells.
Genetics Control Regenerative Properties Of Stem Cells
Researchers define how genetic factors control regenerative properties of blood-forming stem cells.
Diabetes Missing Link Discovered
Researchers from the University of Auckland have shown that beta catenin plays a vital role in the control of insulin release from the pancreas.
Study Reveals New Role for Hippo Pathway in Suppressing Cancer Immunity
Hippo pathway signaling regulates organ size by moderating cell growth, apoptosis and stem cell renewal, but dysregulation contributes to cancer development.
Ribosome Recycling as a Drug Target
Researchers explain mechanism that recycles bacterial ribosomes stalled on messenger RNAs that lack termination codons.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!