Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Crystallography on the Nanogram Scale

Published: Tuesday, April 16, 2013
Last Updated: Tuesday, April 16, 2013
Bookmark and Share
Single Crystal X-ray analysis is a powerful tool for determining the structures of molecules and is widely used both in academic and industrial research.

However, this analytical method has an intrinsic limitation that target samples have to be crystallized beforehand. As a result, most oily compounds or extremely small-quantity samples have not been analyzed by single crystal X-ray study solely because there was no way to crystallize them.

Prof. Makoto Fujita’s research group at the University of Tokyo’s Graduate School of Engineering solved this problem using a porous material called a “crystalline sponge”. Crystalline sponges are porous coordination network crystals capable of aligning incoming guest molecules inside their pores along an ordered framework of organic ligands and metal ions. Once the incoming guest molecules are regularly ordered, the resulting crystalline sponges meet the requirement for X-ray analysis, thus the structure of the guest molecule can be determined by X-ray crystallography without crystallizing the sample itself. The Fujita group demonstrated that molecular structures of non-crystalline samples were unambiguously determined by simply soaking a crystal of crystalline sponge in a solution containing from 80 ng up to 5 µg of the target sample.

With this new “crystalline sponge method,” the Fujita group successfully determined the crystal structures of medicinal compounds, natural flavonoids, and a very scarce marine natural product which is extracted from a marine sponge collected at a depth of 400 m.

This research provides an innovative tool to determine the structures of very tiny amounts of organic molecules in the field of medicinal drug, food, agrichemical, fragrance and fundamental organic research.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
AACR 2016: Cancer Immunotherapy and Beyond
At this year's meeting there was a palpable buzz around subjects ranging from microbiomics to the tumor microenvironment and cancer vaccines, big data to in vitro and in vivo modeling and drug delivery (to name just a few).
How Skeletal Stem Cells Form The Blueprint Of The Face
USC researchers discover that two types of molecular signals work to control where and when stem cells turn into facial cartilage.
Intestinal Worms Boost Immune System In A Surprising Way
EPFL researchers find that intestinal worm infections cause lymph nodes to produce more immune cells as well as grow in size.
Measuring The Airborne Toxicants Urban Bicyclists Inhale
Researchers analyze breath biomarkers to measure uptake of volatile organic compounds by bicyclists.
Breast Milk Hormones Impact Bacteria In Infants’ Guts
Intestinal microbiome of children born to obese mothers significantly different from those born to mothers of healthy weight, CU Anschutz researchers find.
Newborn Screening Test Developed For Rare, Deadly Neurological Disorder
Scientists have developed a new dried blood spot screening test for Niemann-Pick type C, with goal to speed diagnosis and treatment.
'Kidney on a Chip' Facilitates Safer Drug Dosing
University of Michigan researchers have used a "kidney on a chip" device to mimic the flow of medication through human kidneys and measure its effect on kidney cells.
New Autism Blood Biomarker Identified
Researchers at UT Southwestern Medical Center have identified a blood biomarker that may aid in earlier diagnosis of children with autism spectrum disorder, or ASD.
New Method Allows First Look At Embryo Implantation
Researchers at The Rockefeller University develop a method that shows the molecular and cellular processes that occur up to day 14 after fertilization.
Shining A Light On Bladder Cancer
Researchers scrutinize patterns of mutations in bladder tumor genomes, gleaning insights into the roles of DNA repair and tobacco-related DNA damage.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!