Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Crystallography on the Nanogram Scale

Published: Tuesday, April 16, 2013
Last Updated: Tuesday, April 16, 2013
Bookmark and Share
Single Crystal X-ray analysis is a powerful tool for determining the structures of molecules and is widely used both in academic and industrial research.

However, this analytical method has an intrinsic limitation that target samples have to be crystallized beforehand. As a result, most oily compounds or extremely small-quantity samples have not been analyzed by single crystal X-ray study solely because there was no way to crystallize them.

Prof. Makoto Fujita’s research group at the University of Tokyo’s Graduate School of Engineering solved this problem using a porous material called a “crystalline sponge”. Crystalline sponges are porous coordination network crystals capable of aligning incoming guest molecules inside their pores along an ordered framework of organic ligands and metal ions. Once the incoming guest molecules are regularly ordered, the resulting crystalline sponges meet the requirement for X-ray analysis, thus the structure of the guest molecule can be determined by X-ray crystallography without crystallizing the sample itself. The Fujita group demonstrated that molecular structures of non-crystalline samples were unambiguously determined by simply soaking a crystal of crystalline sponge in a solution containing from 80 ng up to 5 µg of the target sample.

With this new “crystalline sponge method,” the Fujita group successfully determined the crystal structures of medicinal compounds, natural flavonoids, and a very scarce marine natural product which is extracted from a marine sponge collected at a depth of 400 m.

This research provides an innovative tool to determine the structures of very tiny amounts of organic molecules in the field of medicinal drug, food, agrichemical, fragrance and fundamental organic research.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Flu Vaccine May Reduce Risk of Death For Type 2 Diabetes Patients
Researchers at Imperial College London have suggested that the vaccine may have substantial benefits for patients with long-term conditions.
Cancer Gene-Drug Combinations Ripe for Precision Medicine
The study aims to expand the number of cancer gene mutations that can be pair with a precision therapy.
Porphyrins as Catalysts in Scalable Organic Reactions
This review covers the most relevant scalable porphyrin-catalysed procedures, showing how these compounds represent broad applications in chemistry.
Core-Shell Columns in HPLC: Food Analysis Applications
Explore the most recent applications of core-shell columns in food analysis.
Review of the Analysis of Haemoglobin A1c for Diabetes Diagnostics
This paper aims to clarify methods, units, quality requirements, reference and cutoff limits for hemoglobin A1c (HbA1c) and ratio of blood glucose/HbA1c on the basis of the results from Finnish quality control surveys by comparing them to the literature.
Colon Cancer Blocked in Mice
Case Western Reserve University Researchers block common type of colon cancer tumour in mice, laying groundwork for human clinical trial.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Disrupting Tumour-Promotion in Humans
Researchers have modified an existing protein to represses a specific cancer-promoting ‘message’ within cells.
Protein Nanocages Could Improve Drug Design and Delivery
HHMI scientists have designed and built 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!