Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Gene Signature Can Predict Who Will Survive Chemotherapy

Published: Tuesday, April 16, 2013
Last Updated: Tuesday, April 16, 2013
Bookmark and Share
An eight gene ‘signature’ can predict length of relapse-free survival after chemotherapy, finds new research in Biomed Central’s open access journal BMC Medicine.

Researchers from Academia Sinica and the National Taiwan University College of Medicine first identified genes that were involved in cellular invasion, a property of many cancer cells, using the National Cancer Institute’s 60 human cancer cell line panel (NCI-60). Comparing the pattern of activation of each of these genes in different cell lines with how these cell lines responded to 99 different anti-cancer drugs,  helped narrow down the list of genes to just those which could potentially influence the outcome of chemotherapy.

Testing this link, Prof Ker-Chau Li, from Academia Sinica and UCLA, commented, “Our study found eight genes which were involved in invasion, and the relative activation of these genes correlated to  chemotherapy outcome, including the receptor for growth factor EGF. We also found that some invasion genes had unique patterns of expression that reflect  the differential cell  responses to each of the chemotherapy agents - five drugs (paclitaxel, docetaxel, erlotinib, everolimus and dasatinib) had the greatest effect.”

When the researchers looked at gene expression data of these eight genes from cancer cell lines they found that there was an obvious difference between cells which responded to chemotherapy and those who did not (albeit with some overlap). In clinical studies, looking at lung and breast cancer, the patients, whose gene signature put them in the low-risk group, had a longer relapse free survival than the high-risk group.

Prof Pan-Chyr Yang of National Taiwan University  added, “The discovery of prognostic biomarkers for chemotherapy patients remains critical toward improving the efficacy of cancer treatment. The eight-gene signature obtained here may help choice of treatment as part of individualized cancer therapy and our method of gene discovery may be applicable in studying other cancers.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Imaging Software Could Speed Up Breast Cancer Diagnosis
Researchers use high speed optical microscopy of intact breast tissue specimens to analyze breast tissue.
Friday, August 21, 2015
Detecting and Identifying Candida Species in Blood Samples of Critically Ill Paediatric Patients
The study aimed to develop a multiplex nested PCR method to detect and identify seven Candida species in peripheral blood samples of critically ill paediatric patients.
Wednesday, August 27, 2014
Researchers Identify Urgent Need for Alzheimer's Disease Drug Development
Analysis of clinical trials published in the journal Alzheimer's Research & Therapy shows that the pipeline for potential treatments of AD is small and rate of success is limited.
Friday, July 04, 2014
Showing Your Age: Your DNA Doesn't Lie
Using thousands of tissue samples from open access datasets, a scientist has created a calculator which predicts the age of tissue using chemical changes to DNA.
Monday, October 21, 2013
Leukaemia Drug Could Help Treat Breast Cancer
A drug currently used to treat leukaemia might also help prevent breast cancer from spreading to other parts of the body.
Friday, August 23, 2013
No Place to Hide: Evolutionary Forensics
The rapid molecular evolution of hepatitis C virus (HCV) has been used to help incriminate the source of an outbreak in two Spanish hospitals in the late nineties.
Monday, July 29, 2013
A Possible Blood Test for Alzheimer’s Disease
A new blood test can be used to discriminate between people with Alzheimer's disease and healthy controls.
Monday, July 29, 2013
Is Enough Being Done to Make Drinking Water Safe?
Arsenic in water is threatening the lives of several hundred million people.
Monday, June 03, 2013
Women’s Immune Systems Remain Younger for Longer
The slower decline in a woman’s immune system may contribute to women living longer than men.
Wednesday, May 15, 2013
Testing the Water – Urine Test Identifies Babies at Most Risk of Necrotizing Enterocolitis
Abnormal gut bacteria in premature babies can be found days before the onset of necrotizing enterocolitis (NEC) finds new research in BioMed Central’s open access journal Microbiome.
Tuesday, April 16, 2013
The Tulip Tree Reveals Mitochondrial Genome of Ancestral Flowering Plant
The extraordinary level of conservation of the tulip tree mitochondrial genome has redefined our interpretation of evolution of the angiosperms (flowering plants).
Tuesday, April 16, 2013
Organizing Human Specimen Collections: Getting the Best out of Biobanks
The diversity of biobanks, collections of human specimens from a variety of sources, raises questions about the best way to manage and govern them.
Friday, March 22, 2013
Oxygen-Free Energy Designed to Fuel Brain Development Spurs on Growth of Cancer
The metabolic process which fuels the growth of many cancers has its origins in normal brain growth finds a new study published in BioMed Central's open access journal Cancer & Metabolism.
Wednesday, January 23, 2013
What Did Our Ancestors Look Like?
A new method of establishing hair and eye colour from modern forensic samples can also be used to identify details from ancient human remains.
Monday, January 14, 2013
Microevolutionary Analysis of C. difficile Genomes to Investigate Transmission
Recent study took a genomics approach to assess the incidence of patient-to-patient transmission of C. difficile.
Thursday, January 03, 2013
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
World’s Largest Coral Gene Database
‘Genetic toolkit’ will help shed light on which species survive climate change.
A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
Breast Cancer Drug Hope
A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.
Untangling Disease-Related Protein Misfolding
Work advances understanding of genetic forms of thrombosis, emphysema, cirrhosis of the liver, neurodegenerative diseases and inflammation, among others.
Early Genetic Changes in Premalignant Colorectal Tissue Identified
Findings point to drivers of early cancer development, targets for cancer prevention therapies.
Harnessing Nature’s Vast Array of Venoms for Drug Discovery
Scripps scientists have developed a method for rapidly identifying venoms.
Nanoparticles Target, Transform Fat Tissue
Nanoparticles designed to target white fat and convert it to calorie-burning brown fat slowed weight gain in obese mice without affecting food intake. This proof-of-concept work could lead to new therapies to treat obesity.
New Cancer Fighters Emerge From Lab
Rice University lab simplifies total synthesis of anti-cancer agent.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!