Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

AmpliPhi Establishes Collaboration with Intrexon

Published: Thursday, April 18, 2013
Last Updated: Thursday, April 18, 2013
Bookmark and Share
Combined expertise to create new generation of bacteriophage-based therapeutics for antibiotic resistant infections.

AmpliPhi BioSciences Corp. and Intrexon Corporation have announced the formation of an exclusive channel collaboration (“ECC”) to develop new bacteriophage-based therapies to target specific antibiotic resistant infections, some of the most widespread and deadly types of infections.

The collaboration seeks to develop bacteriophage-containing human therapeutics for use in the treatment of bacterial infections associated with acute and chronic wounds, the treatment of acute and chronic P aeruginosa lung infections, and the treatment of infections of C. difficile.

Philip J. Young, President and Chief Executive Officer of AmpliPhi, said, “The global market for anti-infective therapies is expected to reach $40 billion annually by 2014. Combining Intrexon’s synthetic biology technologies with our phage development expertise gives us the opportunity to develop and bring to market an important new generation of anti-infective therapies that have the potential to save or change the lives of millions of people.”

Randal J. Kirk, CEO and Chairman of the Board of Intrexon, added, “This collaboration with AmpliPhi should at last make practical the long-appreciated therapeutic potential of phage therapies, resulting in an armamentarium of new treatments for infectious diseases. We are delighted to get underway on this exciting program.”

Under the terms of the ECC agreement, AmpliPhi will receive an exclusive, worldwide license to utilize Intrexon’s proprietary technology and expertise toward the standardized production of wild type phages, as well as for the design and production of genetically modified bacteriophages.

Intrexon will apply its proprietary technologies, including the UltraVector® platform, DNA and RNA MOD engineering, protein engineering, inducible gene systems, genome engineering, and cell systems engineering, to AmpliPhi’s bacteriophage programs.

AmpliPhi will issue to Intrexon 24,000,000 shares of its common stock (representing approximately 26% of Ampliphi’s outstanding shares after the issuance).

The ECC also includes the potential for development milestones that are payable in equity or cash. In addition, AmpliPhi will pay Intrexon royalties on the net sales of products developed under the ECC.

Griffin Securities served as financial advisor to Intrexon in connection with the transaction.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

AmpliPhi Announces the Appointment of Baxter Phillips
Industry leader brings broad strategic and licensing experience in development and commercial stage biopharmaceutical companies.
Thursday, November 14, 2013
AmpliPhi Signs Exclusive License With University of Leicester, UK
Collaboration and license agreement to develop bacteriophage therapies targeting Clostridium difficile.
Friday, October 18, 2013
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Promising Drug Combination for Advanced Prostate Cancer
A new drug combination may be effective in treating men with metastatic prostate cancer. Preliminary results of this new approach are encouraging and have led to an ongoing international study being conducted in 196 hospitals worldwide.
A Cellular Symphony Responsible for Autoimmune Disease
Broad Institute researchers have used a novel approach to increase our understanding of the immune system as a whole.
When it Comes to Breast Cancer, Common Pigeon is No Bird Brain
If pigeons went to medical school and specialized in pathology or radiology, they’d be pretty good at distinguishing digitized microscope slides and mammograms of normal vs. cancerous breast tissue, a new study has found.
Editing of LIMS Data Made Faster and More Efficient in Matrix Gemini
The latest version of the Matrix Gemini LIMS (Laboratory Information Management System) from Autoscribe Informatics now provides faster and more efficient editing of LIMS data by eliminating the need for a second editing screen.
University of Edinburgh, Selcia Achieve Key Milestones in Drug Development Program
Scientists from the University of Edinburgh, working with Selcia, have successfully passed the 20-month milestone targets of a 30-month Wellcome Trust SDDi £2.5 million project to design novel treatments for sleeping sickness.
Red Clover Genome to Help Restore Sustainable Farming
The Genome Analysis Centre (TGAC) in collaboration with IBERS, has sequenced and assembled the DNA of red clover to help breeders improve the beneficial traits of this important forage crop.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos