Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Advanced Seeding Techniques Optimize Crystallization Results

Published: Wednesday, April 24, 2013
Last Updated: Wednesday, April 24, 2013
Bookmark and Share
New technologies for crystallization development.

Mettler Toledo has announced the publication of the latest installment in its industry-leading white paper series. This free, downloadable paper entitled “Recent Advances for Seeding a Crystallization Process: A Review of Modern Techniques” explores crystallization experiments that, coupled with advanced seeding techniques and real-time in situ process feedback, provide results which significantly improve yields and reduce manufacturing costs.

Seeding has become a critical and widely-used step to optimize crystallization behavior, process efficiency, and product quality.

However, a non-ideal seeding protocol can result in inconsistent filtration rates, drying times, yields, bulk density, flow properties and particle size distribution-any of which can disrupt downstream processing, potentially resulting in costly rework or even expensive product loss.

The addition of in situ particle monitoring helps researchers choose optimal seeding conditions based on parameters such as temperature, mass, and particle size distribution.

In reported experiments, heightened process control helped establish efficient, repeatable crystallization processes that achieved important goals such as more predictable manufacturing outcomes, purer products, enhanced consumer safety, and lower overall production expenses.

The white paper details both general seeding theory and use of inline particle measurement tools such as Focused Beam Reflectance Measurement (FBRM®), Particle Vision and Measurement (PVM®), and ATR-FTIR (ReactIR™) which allowed real-time process monitoring.

Results include significantly improved fine particle counts which eliminated the need for post-crystallization milling. In practical application, this benefit has been shown to shorten production schedules for faster time-to-market, an essential ingredient in cost-effective chemical and pharmaceutical manufacturing in today’s highly competitive global marketplace.

For more detail on how optimized seeding can help produce the kind of crystallization results that reduce manufacturing costs, enhance results, and improve safety, download the white paper free at

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

13 Ways to Stop an Unseen Force from Disrupting Weighing
Download a free Mettler Toledo paper to discover how to halt static’s negative effects before the next weigh-in.
Saturday, October 03, 2015
Lab Scale Manufacturing Using Continuous Crystallization
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.
Tuesday, April 15, 2014
Mettler-Toledo Awarded Foreign Designated Manufacturer Certification
Mettler Toledo is the first balance manufacturer to win FDM certification in Japan.
Friday, July 26, 2013
Free Webinar Explores Safe Scaling of Pressure Reactions
Robust in situ technology allows cost effective scale-up pressure reactions.
Friday, May 24, 2013
Pharma Tech Trends and Development Cost Solutions
METTLER TOLEDO’s new on-demand webinar, “Methods to Improve Chemical Process Development,” takes on the challenges of today’s pharmaceutical market.
Thursday, April 04, 2013
Mettler-Toledo and Konica Minolta Join Forces
Strategic partnership in the field of multi-parameter analysis for the Flavours & Fragrances industry.
Friday, May 18, 2012
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos