Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Ono Enters into License Agreement with Bial

Published: Tuesday, April 30, 2013
Last Updated: Tuesday, April 30, 2013
Bookmark and Share
Ono Pharmaceutical Co., Ltd. announced that the company has obtained the right to exclusively develop and commercialize BIA 9-1067.

BIA 9-1067 (development code) (generic name: Opicapone) in Japan, is a long acting COMT (Cathechol-O-Methyl Transferase) inhibitor originated by and currently being developed outside Japan by Bial (Porto, Portugal, CEO: António Portela) for the treatment of symptom reemergence due to levodopa “wearing-off” in Parkinson’s disease (PD).

Under the License Agreement, Ono will pay Bial an upfront fee and development and sales milestones based on the development stage and sales performance of Opicapone.

Opicapone is an adjunct therapy to levodopa preparations (levodopa/carbidopa or levodopa/benserazide) in PD patients. It is well established that levodopa preparations offer the most effective symptomatic treatment of PD. As the disease progresses, PD patients develop “wearing off” phenomenon, where the duration of the effect of levodopa is shortened. To address this “wearing off” phenomenon, adjunctive therapy to levodopa preparations is used to help maintain or boost the effects of levodopa. COMT inhibitors have been widely used to prolong the duration of levodopa effect.

The existing COMT inhibitor in Japan requires multiple administration per day due to its short duration of action and is concomitantly administered with each levodopa preparation.

Phase 3 clinical studies of Opicapone by BIAL are currently ongoing and in clinical studies so far it has demonstrated an increase in the systemic exposure to levodopa and showed a long-lasting effect on COMT inhibition from once daily dosing. Opicapone is expected to improve a dosing convenience, compared to the existing COMT inhibitor in Japan.

Ono will continue to make great efforts to offer a new drug which truly contributes to patients wellbeing and fulfills unmet medical needs.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Connectome Map More Than Doubles Human Cortex’s Known Regions
Researchers at NIH have developed software that automatically detects the “fingerprint” of each of these areas in an individual’s brain scans.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
Human Stem Cells to Rapidly Generate Bone, Heart Muscle
A new study shows that combining positive and negative signals can quickly and efficiently steer stem cells down complex developmental pathways to become specialized tissues that could be used in the clinic.
New Mechanism of Tuberculosis Infection
Researchers at UTSW Medical Center have identified a new way that tuberculosis bacteria get into the body, revealing a potential therapeutic angle to explore.
New Therapeutic Targets For Small Cell Lung Cancer Identified
Researchers at UTSW Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer and that, when deleted in the lungs of mice, prevents the cancer from forming.
Eliminating Doubt in Criminal Investigations
New ASU certificate to help curb error, misunderstanding in the quest for justice.
Determination of 13 Organic Toxicants in Human Blood
Researchers have utilised liquid-liquid extraction coupling HPLC-MS/MS to identify and quantify organic toxicants in human blood.
A Novel Cell Culture Model For Forensic Biology Experiments
Researchers have developed a new cell culture model which provides an efficient research tool in forensic biology.
Rhino DNA Bank Aids Anti-Poaching Fight
At the University of Pretoria's Veterinary Genetics Laboratory (VGL) at Onderstepoort, Dr Cindy Harper and her team have developed a ground-breaking technique to collect and catalogue DNA from rhinos and rhino horns.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!