Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Silk and Cellulose Biologically Effective for Use in Stem Cell Cartilage Repair

Published: Wednesday, May 08, 2013
Last Updated: Wednesday, May 08, 2013
Bookmark and Share
Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage.

Stem cells offer a promising way forward but a key challenge has been to design a ‘smart material’ that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer.

The EPSRC-funded study, published in Biomacromolecules and undertaken by University of Bristol researchers, explored the feasibility of using natural fibres such as silk and cellulose as stem cell scaffolds – the matrix to which stem cells can cling to as they grow.

Both cellulose and silk are commonly used in textiles but the researchers demonstrated an unexpected use for the two natural polymers when mixed with stem cells.  The team treated blends of silk and cellulose for use as a tiny scaffold that allows adult connective tissue stem cells to form into preliminary form of chondrocytes — the cells that make healthy tissue cartilage — and secrete extracellular matrix similar to natural cartilage.

Dr Wael Kafienah, lead author from the University’s School of Cellular and Molecular Medicine, said: “We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors. This new blend can cut the cost for health providers and makes progress towards effective cell-based therapy for cartilage repair a step closer.”

Dr Sameer Rahatekar, lead author from the University’s Advanced Composite Centre for Innovation and Science (ACCIS), added: “We used ionic liquids for the first time to produce cellulose and silk scaffolds for stem cells differentiation.  These liquids are effective in dissolving biopolymers and are environmentally benign compared to traditional solvents used for processing of cellulose and silk.”

The teams are currently working on the fabrication of 3D structures from the blend suitable for implantation in patient joints with future studies focusing on understanding the peculiar interactions between the blend and stem cells towards refining the quality of regenerated cartilage.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Gene Variation Identified for Teen Binge-Eating
Researchers have identified a gene variant which can lead to teenage binge eating, they hope that their work will inform the development of future preventative measures.
Wednesday, July 22, 2015
What Causes Immune Cell Migration To Wounds
Study shows triggers which lead immune cells to react and respond to wounded sites.
Friday, May 29, 2015
Fighting Prostate Cancer with a Tomato-Rich Diet
New research suggests that men who eat over 10 portions of tomatoes a week have an 18% lower risk of developing prostate cancer.
Thursday, August 28, 2014
Breakthrough Shows How DNA is ‘Edited’ to Correct Genetic Diseases
An international team of scientists has made a major step forward in our understanding of how enzymes 'edit' genes, paving the way for correcting genetic diseases in patients.
Wednesday, May 28, 2014
Deciphering the Role of Fat Stem Cells in Obesity and Diabetes
New study will examine stem cells to pinpoint how excess fat is stored, potentially paving the way for new treatments to combat obesity-linked diseases.
Wednesday, May 21, 2014
Molecular Biology Mystery Unravelled
Machinery responsible for the entry of proteins into cell membranes.
Saturday, February 22, 2014
Beauty and the Lab: Scientists Reveal the Art of Science
From a heart-shaped cell nucleus to a 3D molecular syringe, creative scientists have revealed the beauty found in complex and technical research.
Monday, December 16, 2013
New Swine Influenza Project to Better Understand Virus Transmission
The Pirbright Institute in Surrey has been awarded £4.4 million to work with researchers from universities on a long-term study on the transmission of swine influenza.
Friday, December 13, 2013
Global Carbon Dioxide Emissions to Reach 36 Billion Tonnes in 2013
Global emissions of carbon dioxide from the combustion of fossil fuels will reach 36 billion tonnes for the year 2013 – a level unprecedented in human history.
Tuesday, November 26, 2013
Human Neural Stem Cells Could Meet the Clinical Problem of Critical Limb Ischemia
New research has shown human neural stem cells could improve blood flow in critical limb ischemia through the growth of new vessels.
Monday, November 25, 2013
Bristol Spearheads UK’s Role in €4 Million Synthetic Biology Project
The University of Bristol has been awarded a share of a €4million (£3.3million) European Union grant to improve public awareness of synthetic biology.
Tuesday, November 19, 2013
North Atlantic Atmospheric Circulation Increases Mountainous Weather Systems and River Flow in Upland Britain
The North Atlantic Oscillation (NAO) is the most important type of climatic variability in the northern hemisphere.
Friday, August 09, 2013
New Findings Could Influence the Development of Therapies to Treat Dengue Disease
New research into the fight against Dengue may influence the development of anti-viral therapies that are effective against all four types of the virus.
Monday, August 05, 2013
Cheap Anti-Cancer Drug is Effective in Treating Most Common Cause of Blindness in Older Adults
An anti-cancer drug has been proven to be equally as effective in treating the most common cause of blindness in older adults as a more expensive drug specifically formulated for this purpose.
Friday, July 19, 2013
Genome of 700,000-Year-Old Horse Sequenced
The oldest genome so far from a prehistoric creature has been sequenced by an international team.
Thursday, June 27, 2013
Scientific News
NIH Study Finds Calorie Restriction Lowers Some Risk Factors for Age-Related Diseases
Two-year trial did not produce expected metabolic changes, but influenced other life span markers.
Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial
Daratumumab proved generally safe in patients, even at the highest doses.
Low-level Arsenic Exposure Before Birth Associated with Early Puberty in Female Mice
Study examine whether low-dose arsenic exposure could have similar health outcomes in humans.
Inciting an Immune Attack On Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
‘Mutation-Tracking’ Blood Test for Breast Cancer
Scientists have developed a blood test for breast cancer able to identify which patients will suffer a relapse after treatment, months before tumours are visible on hospital scans.
Cellular Contamination Pathway for Heavy Elements Identified
Berkeley Lab scientists find that an iron-binding protein can transport actinides into cells.
Intensity of Desert Storms May Affect Ocean Phytoplankton
MIT study finds phytoplankton are extremely sensitive to changing levels of desert dust.
Common ‘Heart Attack’ Blood Test May Predict Future Hypertension
Small rises in troponin levels may have value as markers for subclinical heart damage and high blood pressure.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!