Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Aileron Therapeutics Successfully Completes First-Ever Stapled Peptide Clinical Trial

Published: Thursday, May 09, 2013
Last Updated: Thursday, May 09, 2013
Bookmark and Share
Safety and pharmacokinetics of ALRN-5281, a long-acting growth-hormone-releasing-hormone agonist, established in single-ascending dose study.

Aileron Therapeutics, Inc. announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.

“The successful translation of a Stapled Peptide drug into human subjects has long been our goal. It is an important milestone for Aileron, as well as for the rapidly emerging Stapled Peptide field as a whole,” said Joseph A. Yanchik, III, president, chief executive officer and co-founder of Aileron. “We are proud to pioneer the first clinical trial of Stapled Peptides, and we look forward to continuing our leadership in the development and eventual commercialization of this promising therapeutic class.”

The initial Phase 1 trial evaluated the safety and tolerability of single ascending doses of ALRN-5281 administered by subcutaneous injection in healthy adult subjects. Additional study objectives included the evaluation of pharmacokinetics (PK) and exploratory pharmacodynamic (PD) biomarkers of ALRN-5281. Thirty-two subjects completed the study. There were no serious adverse events, dose-limiting safety findings, or tolerability issues leading to withdrawal during the study.

“We now have clinical data showing that Aileron’s Stapled Peptides are capable of delivering a drug product profile previously believed to be out of reach with traditional peptide-based therapeutics, in particular PK attributes that support once-weekly dosing,” said Hubert C. Chen, M.D., vice president of clinical development at Aileron. “We are encouraged by the prospects of ALRN-5281 to demonstrate improved safety, efficacy, and convenience over currently available GH and GHRH injections. The results of this initial trial will guide us in optimizing dose selection and frequency for ALRN-5281 as a potential best-in-class therapy.”

Stapled Peptides are a new class of drugs with a unique set of properties that fully capitalize on 25 years of genetic research to attack drivers of complex diseases, including cancer, endocrine/metabolic disorders and inflammation. The Stapled Peptide platform locks peptides into their biologically active shape and imparts pharmaceutical stability within the body. Stapled Peptide drugs, such as ALRN-5281, are derived from natural peptides and are designed to remain in a safe and effective therapeutic range longer than traditional peptide hormones. This new class of drugs represents a fundamental scientific breakthrough as they offer the most advanced way to replicate normal human physiology to treat human disease.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos