Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genetic Test Helps Predict Risk of Prostate Cancer Recurrence

Published: Friday, May 10, 2013
Last Updated: Friday, May 10, 2013
Bookmark and Share
Prostate cancer ranks as the most common internal malignancy diagnosed in men in the United States, but often does not require extensive treatment.

A study using tissue samples from men who underwent surgical removal of the prostate at UC San Francisco confirmed that a genetic test that measures cell cycle progression (CCP) — an indicator of how rapidly cancer cells are growing and dividing — can be a useful tool for predicting who will have a recurrence of the disease, especially when combined with existing information from laboratory and pathology tests.

The CCP score provides a biomarker that eventually might help guide decisions about whether to pursue additional treatment after surgery, such as radiation therapy.

The study, published in the Journal of Clinical Oncology (2013 Apr 10;31(11):1428-34), used the UCSF Urologic Oncology Database to access tissue samples and medical records from men who had undergone prostatectomy at UCSF and been followed for at least five years after surgery.

A commercial laboratory operated by Myriad Genetics, the company that developed the test, conducted genetic analysis of the tissue samples to determine a CCP score in 413 patients. The researchers at UCSF then examined how well the CCP score predicted which men had a recurrence of their disease after surgery.

The CCP score was also evaluated with another validated predictive score, the Cancer of the Prostate Risk Assessment post-surgery score (CAPRA-S). The CAPRA-S score is based on preoperative PSA levels and information gleaned from surgery, including how much the tumor has invaded tissues surrounding the prostate and how aggressive he cancer cells look when examined under a microscope.

Investigators found that the CAPRA-S and CCP together they were more useful than either alone, and that adding the CCP was especially helpful in men who appeared to have low-risk disease based on the CAPRA-S score alone.

In addition to the 413 patients in the UCSF group, the researchers also looked at the predictive results of the CCP combined with the CAPRA-S in a group of patients previously studied at the Scott and White Clinic in Georgetown, TX, for whom longer-term follow-up was available. The combination of the CCP and CAPRA-S again accurately predicted recurrence in this group.

“One of the big challenges in prostate cancer is knowing when and how aggressively to treat patients,” said Matthew R. Cooperberg, MD, MPH, lead author of the study. “Biomarkers such as the CCP can provide valuable data to guide treatment decisions.”

The UCSF Urology Department is currently running additional studies with the CCP score, as well as other promising biomarkers and imaging tests, in men who have not undergone surgery or other treatments.

“Our hope is that these tests will help more men with low-risk prostate cancer avoid unnecessary treatment, while ensuring that those with more aggressive cancers do not miss the window of opportunity for cure,” said Cooperberg.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genome Sequencing May Help Avert Banana Armageddon
Researchers at the University of California, Davis, and in the Netherlands have discovered how three fungal diseases have evolved into a lethal threat to the world’s bananas.
Friday, August 12, 2016
‘Human-on-a-Chip’ Could Replace Animal Testing
Researchers are developing a “human-on-a-chip,” a miniature external replication of the human body, integrating biology and engineering with a combination of microfluidics and multi-electrode arrays.
Monday, June 13, 2016
Unveiling the Complexity of Mysterious Protein Folding
Imagine trying to reverse engineer a car when all you have is a finished product or a box full of parts — no instructions.
Wednesday, June 01, 2016
Study Identifies How Brain Connects Memories Across Time
UCLA Neuroscientists have boost ability of aging brain to recapture links between related memories.
Tuesday, May 31, 2016
Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
Thursday, May 19, 2016
An E.coli Detector May be in Your Hands Soon
Hand-held device that can be used to detect a variety of pathogens—including foodborne pathogens like E. coli—at all stages in the food supply chain, from fields to restaurants may be available soon.
Monday, May 16, 2016
Fructose Alters Hundreds of Brain Genes
UCLA scientists report that diet rich in omega-3 fatty acids can reverse the damage.
Tuesday, April 26, 2016
Study Yields the Key to Effective Personalized Medicine
A team of UCLA bioengineers and surgeons has taken a major step toward making personalized medicine a reality.
Monday, April 11, 2016
Tracking RNA in Live Cells
Technique may open doors to new treatments for many conditions, from cancer to autism.
Friday, March 18, 2016
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Monday, February 08, 2016
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Monday, February 08, 2016
Toxic Pollutants Found in Fish Across the World's Oceans
Scripps researchers' analysis shows highly variable pollutant concentrations in fish meat.
Friday, January 29, 2016
Key Enzyme in Pierce’s Disease Grapevine Damage Uncovered
UC Davis plant scientists have identified an enzyme that appears to play a key role in the insect-transmitted bacterial infection of grapevines with Pierce’s disease, which annually costs California’s grape and wine industries more than $100 million.
Wednesday, January 13, 2016
Science Magazine Names CRISPR ‘Breakthrough of the Year’
In its year-end issue, the journal Science chose the CRISPR genome-editing technology invented at UC Berkeley 2015’s Breakthrough of the Year.
Monday, December 21, 2015
Genome Sequencing May Save California's Legendary Sugar Pine
The genome of California’s legendary sugar pine, which naturalist John Muir declared to be “king of the conifers” more than a century ago, has been sequenced by a research team led by UC Davis scientists.
Thursday, December 17, 2015
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
A Diversity of Genomes
New DNA from understudied groups reveals modern genetic variation, ancient population shifts.
“Sixth Sense” May Be More Than Just A Feeling
The NIH Study shows that two young patients with a mutation in the PIEZ02 have problems with touch and proprioception, or body awareness.
Gene Could Reduce Female Mosquitoes
Virginia Tech researchers have found a gene that can reduce female mosquitoes over many generations.
Biomolecular Manufacturing ‘On-the-Go’
Wyss Institute team unveils a low-cost, portable method to manufacture biomolecules for a wide range of vaccines, other therapies as well as diagnostics.
Improving Crop Efficiency with CRISPR
New study of CRISPR-Cas9 technology from Virginia Tech shows potential to improve crop efficiency.
Fighting Cancer with Sticky Nanoparticles
Treatment that uses bioadhesive nanoparticles drug carriers proved more effective than conventional treatments for certain cancers.
Stem Cell ‘Heart Patch’ Almost Perfected
Scientists aiming to perfect and test 3D "heart patches" in animal model, last hurdle before human patients.
Fighting Plant Pathogens with RNA
Researchers develop strategy that could lead to environmentally friendly fungicide to fight pathogens.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!