Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

ProQinase and Mercachem Obtain € 2.5 Million EU EUROSTARS Grant

Published: Tuesday, May 14, 2013
Last Updated: Monday, May 13, 2013
Bookmark and Share
Grant to establish epigenetics drug discovery platform.

ProQinase and Mercachem have received a € 2.5 M grant from the EU’s Eurostars program to support their joint efforts in establishing and expanding an innovative small molecule drug discovery platform.

The platform will comprise novel biological and pharmacological assay systems combined with new chemical space libraries targeted against most prominent epigenetic enzyme families.

During a 3 year program biochemical, cell-based, and in vivo test systems will be established alongside with the development of novel scaffold-based compound libraries that qualify for hit generation and subsequent lead finding and optimization campaigns.

Frank Leemhuis, Managing Director of Mercachem, points out: “We are glad that we can strengthen our integrated drug discovery service offering with ProQinase in the emerging field of epigenetics, a very promising field in pharmaceutical and biotech research and development. The funds will enhance our position as a reliable research service provider within the rapidly developing market segment of drug discovery and medicinal chemistry outsourcing.”

Christoph Schächtele, CEO of ProQinase GmbH, further elaborates: “It’s a promising matter to combine our cancer drug discovery know-how with Mercachem’s complementary expertise in medicinal chemistry and to adapt all of this to epigenetic targets. We are convinced that thereby a new drug discovery platform will be formed which offers huge potential for integrated drug discovery projects in collaboration with pharmaceutical companies active in this field.”

“With this grant we have the exciting opportunity to apply our in-house expertise in medicinal chemistry with a focus on modern optimization parameters, such as residence time on target, for the generation of novel chemotypes aimed at most ambitious epigenetic targets.” explained Gerhard Müller, Senior Vice President Medicinal Chemistry at Mercachem.

“Similar to protein kinases, epigenetic enzymes belong to enzyme families of which some members are deregulated in cancer representing promising oncology intervention points. To allow most beneficial epigenetic therapies, novel epigenetic drugs should only block the action of oncogenic, (but not other) members of the respective enzyme family. Hence, we are convinced that our approach that comprises early drug profiling against on- and off-targets of epigenetic enzyme families and a stepwise improvement of inhibitory profiles will allow us to generate improved lead compounds and pre-clinical candidates.” Michael Kubbutat, Head Drug Development of ProQinase, added.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Mercachem to Acquire Prague Business from Synthon
Employees will join Mercachem per the contractually agreed date of 1 October 2014.
Wednesday, September 03, 2014
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients
The research could be a key step in developing treatments to eliminate symptoms that drastically impair the quality of life in Rett patients.
Heart Arrhythmia Caused by Mosaic of Mutant Cells
Researchers have solved the genetic mystery of an infant suffering from heart arrhythmia.
Iron Nanoparticles Make Immune Cells Attack Cancer
Researchers accidentally discover that nanoparticles invented for anemia treatment can trigger the immune system’s ability to destroy tumor cells.
Crispr Toolbox Expanded By Protein
Researchers have shown a newly discovered CRISPR protein has two distinct RNA cutting activities.
CES Score May Predict Response to Cancer Treatment
Researchers identify new type of biomarker that helps predict prognosis and response to several types of cancer treatment.
Uncovering Cancer’s ‘Invisibility Cloak’
Researchers discover cancer cell mechanism to become invisible to the body's immune system.
Genetic Impact of Endurance Training
Research has found that endurance training changes genetic activity in thousands of genes, giving rise to large number of altered RNA variants.
Treating Sepsis with Marine Mitochondria
Mitochondrial alternative oxidase from a marine animal combats bacterial sepsis.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!