Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

CLSI Releases Newborn Screening Document

Published: Wednesday, May 22, 2013
Last Updated: Wednesday, May 22, 2013
Bookmark and Share
NBS06 - A newborn blood spot screening for severe combined immunodeficiency.

Clinical and Laboratory Standards Institute (CLSI) has released NBS06-A-Newborn Blood Spot Screening for Severe Combined Immunodeficiency by Measurement of T-cell Receptor Excision Circles; Approved Guideline.

Severe combined immunodeficiency (SCID) is a lethal disorder not evident at birth. This document addresses its detection by population-based newborn screening (NBS), which uses dried blood spot (DBS) specimens to measure T-cell receptor excision circles (TREC).

TREC may be used to reveal the presence of SCID, and this presymptomatic detection is required for effective treatment.

This guideline, which is intended for use by NBS clinicians, laboratory personnel, producers of laboratory products related to NBS, and those involved with the oversight of NBS programs, facilitates the incorporation of SCID NBS into the routine operation of existing NBS programs.

Methodologically, it focuses on measuring TREC in DBS specimens by real-time quantitative polymerase chain reaction, the method currently in use by all NBS laboratories.

Both startup and operating NBS programs benefit from the use of NBS06, which contains detailed protocols for screening and follow-up.

"There is the potential for a cure with early detection of SCID," said Harry Hannon, PhD, and Roshini Sarah Abraham, PhD, D(ABMLI); Chairholder and Vice-Chairholder of the NBS06-A document development committee. "Newborn screening can save lives from this devastating disorder."

NBS06 conveys detailed information for laboratory practice, including calibration, quality control, and proficiency testing. It also addresses program issues such as short-term follow-up (ie, notification and tracking to establish or rule out a diagnosis).

The guideline includes clinical and immunological background on SCID and other immunodeficiency disorders that may present with low or no TREC content in newborns.

This guideline also boasts several appendixes that showcase information vital to the document, including the first comprehensive tabulation of primary and secondary conditions detected by the TREC assay, and an exemplar generic flow chart for TREC assays in NBS.

SCID NBS is technologically evolving with respect to both laboratory practices and outcome measures. NBS06 provides the foundation for refinements in the future.

The participation and close collaboration of all NBS programs is critical to the success of this endeavor.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Newborn Screening for Cystic Fibrosis - Approved Guideline
This document describes the use of newborn screening laboratory tests for detecting risk for cystic fibrosis from newborn dried blood spots (DBS) and addresses both the primary screening tests and the reflex tests performed on DBS.
Tuesday, December 06, 2011
New Guideline on Establishing Molecular Testing in Clinical Laboratory Environments
The Clinical and Laboratory Standards Institute (CLSI) recently published the document which provides comprehensive guidance for planning and implementation of molecular diagnostic testing.
Tuesday, December 06, 2011
CLSI Publishes Quality Practices in Noninstrumented Point-of-Care Testing
New instructional guideline delivers laboratory science concepts and activities for increasing knowledge and quality of laboratory testing.
Wednesday, December 08, 2010
CLSI Publishes new Approved Guideline for use of Mass Spectrometry in the Clinical Laboratory
The guideline includes guidance, references, and quality assurance markers that will assist with the implementation and correct operation of an MS system for its many applications.
Friday, November 23, 2007
CLSI Guideline Provides Protocols for the use of RNA Controls in Gene Expression Assays
The guideline addresses important issues associated with the use of external RNA controls as a tool for verification of technical performance.
Wednesday, September 20, 2006
Scientific News
RNAi Screening Trends
Understand current trends and learn which application areas are expected to gain in popularity over the next few years.
Diagnostic Test Developed for Enterovirus D68
researchers at Washington University School of Medicine in St. Louis have developed a diagnostic test to quickly detect enterovirus D68 (EV-D68), a respiratory virus that caused unusually severe illness in children last year.
How a Kernel Got Naked and Corn Became King
Ten thousand years ago, a golden grain got naked, brought people together and grew to become one of the top agricultural commodities on the planet.
Sweet Revenge Against Superbugs
A special type of synthetic sugar could be the latest weapon in the fight against superbugs.
New Material Opens Possibilities for Super-Long-Acting Pills
A pH-responsive polymer gel could create swallow able devices, including capsules for ultra-long drug delivery.
How To Keep Your Rice Arsenic-Free
Researchers at Queen’s University Belfast have made a breakthrough in discovering how to lower worrying levels of arsenic in rice that is eaten all over the world.
New Tool For Investigating RNA Gone Awry
A new technology – called “Sticky-flares” – developed by nanomedicine experts at Northwestern University offers the first real-time method to track and observe the dynamics of RNA distribution as it is transported inside living cells.
Computer Model Could Explain how Simple Molecules Took First Step Toward Life
Two Brookhaven researchers developed theoretical model to explain the origins of self-replicating molecules.
New Tech Enables Epigenomic Analysis with a Mere 100 Cells
A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer has been developed by researchers at Virginia Tech.
Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support
A new study reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!