Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Fungal Findings

Published: Monday, June 10, 2013
Last Updated: Monday, June 10, 2013
Bookmark and Share
NIH team used genomic approach to gain a better understanding of the fungi in their new study.

A genomic survey of the fungi living on our skin provides a framework for understanding how these microbes contribute to skin health and disease.

Complex communities of microbes live on the surface of our bodies. These fungi, bacteria and viruses are collectively known as the skin microbiome.

A team from NIH’s National Human Genome Research Institute (NHGRI) and National Cancer Institute (NCI) previously used genomic techniques to study skin bacteria.

They found diverse bacterial communities that varied between people and by skin site. In their new study, the team used a similar genomic approach to gain a better understanding of the fungi that live on our skin.

Fungi include molds, mushrooms, and the yeast that are used to ferment bread and beer. These microbes have been associated with many skin diseases and conditions, including athlete’s foot, eczema, dandruff and toenail infections.

Fungal skin infections affect an estimated 29 million people nationwide. But fungi can be slow and difficult to grow in laboratories, making fungal infections hard to identify and treat.

As described online in Nature on May 22, 2013, the scientists collected samples at 14 body sites from 10 healthy adults. They focused on a fragment of DNA shared by all fungi-the intervening internal transcribed spacer 1 (ITS1) of ribosomal RNA-that could be used to classify fungi at the genus level with greater than 97% accuracy.

By generating more than 5 million ITS1 sequences from the samples, the team was able to identify more than 80 genus-level fungal types living on human skin. In contrast, traditional culturing methods could identify only 18 types.

Ascomycetes and Basidiomycetes were found at all the skin sites. Fungi of the genus Malassezia were the predominant type on 11 of the 14 sites, including behind the ears, in nostrils, on the back, and on the arms.

The team found that heels, which don’t show extensive bacterial diversity, were the most complex site for fungi, with about 80 types represented.

Toe webs, with about 60 types, and toenails, with 40, had the next highest levels of fungal diversity. Hands and arms, which harbor a great diversity of bacteria, had relatively few types of fungi.

Fungal communities on the core body were quite stable over time, with little change when tested up to 3 months apart. In contrast, fungi on the feet altered considerably over 3 months, perhaps reflecting more environmental exposure.

“The fungal communities on the human body are complex and site-specific,” says co-senior author Dr. Heidi Kong of NCI. “By gaining a more complete awareness of the fungal and bacterial ecosystems, we can better address associated skin diseases, including fungal infections, which can be related to cancer treatments.”

“The data from our study gives us a baseline about normal individuals that we never had before,” says co-senior author Dr. Julie Segre of NHGRI. “The bottom line is your feet are teeming with fungal diversity, so wear your flip flops in locker rooms if you don’t want to mix your foot fungi with someone else’s fungi.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Vital Protein in Healthy Fertilization Process Identified
Researchers at the National Institutes of Health have discovered a protein that plays a vital role in healthy egg-sperm union in mice.
Monday, July 27, 2015
Young South African Women can Adhere to Daily PrEP Regimen as HIV Prevention
NIH-funded study finds men in Bangkok, Harlem also successful in taking daily dose.
Saturday, July 25, 2015
Study Shows Promise of Precision Medicine for Most Common Type of Lymphoma
The study appeared online July 20, 2015, in Nature Medicine.
Tuesday, July 21, 2015
NIH Joins Public-Private Partnership to Fund Research on Autism Biomarkers
Biomarkers Consortium project to improve tools for measuring and treating social impairment in children with autism.
Tuesday, July 21, 2015
NIH Study Identifies Gene Variant Linked to Compulsive Drinking
Mice carrying the Met68BDNF gene variant would consume excessive amounts of alcohol.
Tuesday, July 21, 2015
HIV Control Through Treatment Durably Prevents Heterosexual Transmission of Virus
NIH-funded trial proves suppressive antiretroviral therapy for HIV-infected people effective in protecting uninfected partners.
Tuesday, July 21, 2015
Early Antiretroviral Therapy Prevents Non-AIDS Outcomes in HIV-infected People
NIH-supported findings illustrate manifold benefit of therapy.
Tuesday, July 21, 2015
Futuristic Brain Probe Allows for Wireless Control of Neurons
NIH-funded scientists developed an ultra-thin, minimally invasive device for controlling brain cells with drugs and light.
Saturday, July 18, 2015
House Votes in Favor of Bill Boosting NIH Funding
The US House of Representatives today overwhelmingly voted in favor of a bill that would increase funding to the NIH by about $10 billion, help speed the development of new drugs, and advance precision medicine initiatives.
Monday, July 13, 2015
NIH-funded Vaccine for West Nile Virus Enters Human Clinical Trials
Enrollment is expected to be completed by December 2015.
Tuesday, July 07, 2015
In Blinding Eye Disease, Trash-Collecting Cells Go Awry, Accelerate Damage
NIH research points to microglia as potential therapeutic target in retinitis pigmentosa.
Friday, July 03, 2015
Boys More Likely to Have Antipsychotics Prescribed, Regardless of Age
NIH-funded study is the first look at antipsychotic prescriptions patterns in the U.S.
Thursday, July 02, 2015
Potential Therapeutic for Blinding Eye Disease
NIH research points to microglia as potential therapeutic target in retinitis pigmentosa.
Thursday, July 02, 2015
New Medication for Alcohol Use Disorder
NIH begins clinical trial investigating a potential treatment for alcohol use disorder.
Friday, June 26, 2015
NIH Begins Clinical Trial of New Medication for Alcohol Use Disorder
Clinical trial will evaluate the safety and effectiveness of gabapentin enacarbil in treating alcohol use disorder.
Friday, June 26, 2015
Scientific News
RNAi Screening Trends
Understand current trends and learn which application areas are expected to gain in popularity over the next few years.
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
TOPLESS Plants Provide Clues to Human Molecular Interactions
Scientists at Van Andel Research Institute have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic development and to diseases such as cancer.
Toxin from Salmonid Fish has Potential to Treat Cancer
Researchers from the University of Freiburg decode molecular mechanism of fish pathogen.
Study Finds Non-Genetic Cancer Mechanism
Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
Scientists Create CRISPR/Cas9 Knock-In Mutations in Human T Cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
Researchers Find U.S. Breast Milk is Glyphosate Free
Washington State University scientists have found that glyphosate, the main ingredient in the herbicide Roundup, does not accumulate in mother’s breast milk.
Peering into the Vapors
Research suggests that e-cigarettes are much less harmful than previous studies have indicated.
New Technique for Mining Health-conferring Soy Compounds
A new procedure devised by U.S. Department of Agriculture (USDA) scientists to extract lunasin from soybean seeds could expedite further studies of this peptide for its cancer-fighting potential and other health benefits.
Long-sought Discovery Fills in Missing Details of Cell 'Switchboard'
A biomedical breakthrough reveals never-before-seen details of the human body’s cellular switchboard that regulates sensory and hormonal responses.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!