Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Chlamydia Protein has an Odd Structure

Published: Thursday, June 13, 2013
Last Updated: Thursday, June 13, 2013
Bookmark and Share
Research could lead to new ways to combat this sexually transmitted disease.

A protein secreted by the chlamydia bug has a very unusual structure, according to scientists in the School of Medicine at The University of Texas Health Science Center San Antonio. The discovery of the protein's shape could lead to novel strategies for diagnosing and treating chlamydia, a sexually transmitted disease that infects an estimated 2.8 million people in the U.S. each year.

The protein, Pgp3, is secreted by Chlamydia trachomatis, the bacterium that causes chlamydia. Pgp3's shape is very distinguishable — sort of like an Eiffel Tower of proteins. "From a structural standpoint, the protein is very odd indeed," said X-ray crystallographer P. John Hart, Ph.D., the Ewing Halsell President's Council Distinguished Chair in the Department of Biochemistry at the San Antonio medical school. "This long and slender molecule contains a fusion of structural motifs that resemble those typically found in viral and not bacterial proteins." Dr. Hart is co-lead author of the research, which is described in the Journal of Biological Chemistry (JBC).

The Pgp3 protein is a chlamydial virulence factor that is hypothesized to enhance the bug's ability to initially infect its human host and then evade host defenses. "Although my lab has worked on this protein for many years and gained a great deal of knowledge on it, we still don't know what roles it may play in chlamydial pathogenesis (disease development)," said co-lead author Guangming Zhong, M.D., Ph.D., professor of microbiology at the Health Science Center. "With the structural information uncovered in this paper, we can now test many hypotheses."

This is the second chlamydial virulence factor that Dr. Zhong's laboratory has identified; the first was a protein called CPAF. Structural studies have played an important role in understanding CPAF's functions in chlamydial infections, Dr. Zhong said.

Chlamydia's toll

According to the U.S. Centers for Disease Control and Prevention (CDC), more than 1.4 million new cases of chlamydia were reported in 2011 across the 50 states and the District of Columbia. But the CDC says as many cases go unreported because most people with chlamydia have no symptoms and do not seek testing. If left untreated, chlamydia can permanently damage a woman's reproductive system. This can lead to ectopic pregnancy, pelvic inflammatory disease and infertility.

The disease burden of chlamydia worldwide is magnitudes greater, with new cases numbering in the dozens of millions per year. The World Health Organization estimates that 499 million new cases occur annually of four curable sexually transmitted diseases — chlamydia, syphilis, gonorrhea and trichomoniasis. This estimate is for cases in adults aged 15-49.

Chlamydia infection induces inflammatory pathology in humans, and Pgp3 may contribute to the pathology by activating inflammation via one of its structural features uncovered in the crystal structure, said Dr. Zhong, who has worked with Dr. Hart on the Pgp3 project for nearly four years.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More Than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

First-Ever Capsule to Treat Hemophilia
In the near future, hemophiliacs could be able to treat their disease by simply swallowing a capsule.
Wednesday, November 30, 2016
Powerful New Tools to Combat Zika
Researchers have created a way to replicate the stucture of Zika virus, removing the genes that make the virus infectious.
Monday, November 21, 2016
Supercomputing Tumor Suppression Protein Model
TACC/XSEDE's Stampede supercomputer simulates largest atomic level system to date.
Monday, October 31, 2016
New Platform for Roundworms Could Speed Up Drug Delivery
Researchers have developed a large-scale in vitro drug discovery platform that could speed up scientific research.
Tuesday, October 11, 2016
New Insights Into Microbial Evolution
Researchers studing E. coli report that most new genetic mutations that were passed on were beneficial and occurred at much more variable rates.
Thursday, August 04, 2016
Gut Bacteria Older than Human Species
Some bacteria have lived in the human gut since before we were human, suggesting evolution could have a larger role inhuman bacterial makeup.
Friday, July 22, 2016
Lab-Tested Diagnosis Needed When Treating Persistent Diarrhea
New PCR multiplex method makes lab testing more effective.
Wednesday, July 20, 2016
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
Monday, June 27, 2016
Scientific Gains May Make Electronic Nose the Next Everyday Device
UT Dallas team breathes new life into possibilities by using CMOS integrated circuits technology.
Friday, June 17, 2016
New Breast Cancer Staging System
Neo-Bioscore adds HER2 status into previously developed system.
Monday, March 21, 2016
Prostate Cancer Surgery Improved
Researchers at UT Southwestern Medical Center have determined that light reflectance spectroscopy can differentiate between malignant and benign prostate tissue with 85 percent accuracy, a finding that may lead to real-time tissue analysis during prostate cancer surgery.
Monday, March 14, 2016
Leukemia’s Surroundings Key to its Growth
Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.
Friday, February 12, 2016
Flesh-Eating Bacteria Work Together
Scientists recently discovered different strains of deadly flesh-eating bacteria working together to spread infection and they now have a better understanding of the role of the toxins they produce. The discovery could change how the illness and other diseases are treated.
Wednesday, January 27, 2016
Utilizing Antibodies from Ebola Survivors
A collaborative team from The University of Texas Medical Branch at Galveston, Vanderbilt University, The Scripps Research Institute and Integral Molecular Inc. have learned that antibodies in the blood of people who have survived a strain of the Ebola virus can kill various types of Ebola.
Wednesday, January 27, 2016
Mechanism of Tumor Suppressing Gene Uncovered
The most commonly mutated gene in cancer,p53, works to prevent tumor formation by keeping mobile elements in check that otherwise lead to genomic instability, UT Southwestern Medical Center researchers have found.
Tuesday, January 26, 2016
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Soil Carbon Release Might Equal U.S. Emissions
Research suggests 55M tons of carbon will be release from soils by 2050, 17% higher than prjected emissions.
‘NoBody,’ a Microprotein On a Mission
Researchers identify over 400 microproteins encoded in the human genome, one of which clears unneeded genetic material inside cells.
Unexpected Epigenetic Enzymes Role in Cancer
Researchers use epigenetics to identify the role of an enzyme family as regulators of genetic message interpretation in yeast.
Genetic Links to Brain Cancer Cell Growth
Researchers discover clues to tumour behaviour from genetic differences between brain cancer cells and normal tissue cells.
New Form of Autism Found
An international team of researchers have identified a new form of syndromic autism.
Radiation-Free Imaging in the Brain
Scientists create sensors that use proteins to detect particular targets through induced blood flow changes.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!