Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

University of Toronto Breakthrough Allows Fast, Reliable Identification of Pathogens

Published: Friday, June 21, 2013
Last Updated: Friday, June 21, 2013
Bookmark and Share
Researchers have created an electronic chip that can analyze blood and other clinical samples for infectious bacteria with record-breaking speed.

Life-threatening bacterial infections cause tens of thousands of deaths every year in North America but current methods of culturing bacteria in the lab can take days to report the specific source of the infection, and even longer to pinpoint the right antibiotic that will clear the infection.

The new technology, reported in the journal Nature Communications, can identify the pathogen in a matter of minutes, and looks for many different bacteria and drug resistance markers in parallel, allowing rapid and specific identification of infectious agents.

“Overuse of antibiotics is driving the continued emergence of drug-resistant bacteria,” said Shana Kelley (Pharmacy and Biochemistry), a senior author of the study. “A chief reason for use of ineffective or inappropriate antibiotics is the lack of a technology that rapidly offers physicians detailed information about the specific cause of the infection.”

Many infections are resistant to first-line antibiotics and there is an urgent, unmet need for technologies that can allow bacterial infections to be rapidly and specifically diagnosed, Kelley said.
The researchers developed an integrated circuit that could detect bacteria at concentrations found in patients presenting with a urinary tract infection.

“The chip reported accurately on the type of bacteria in a sample, along with whether the pathogen possessed drug resistance,” explained Chemistry Ph.D. student Brian Lam, the first author of the study.

One key to the advance was the design of an integrated circuit that could accommodate a panel of many biomarkers.

“The team discovered how to use the liquids in which biological samples are immersed as a ‘switch’ – allowing us to look separately for each biomarker in the sample in turn,” said Ted Sargent (Electrical and Computer Engineering), the other senior author of the report.

“The solution-based circuit chip rapidly and identifies and determines the antibiotic resistance of multiple pathogens – this represents a significant advance in biomolecular sensing,” said Paul S. Weiss, Kavli Chair in NanoSystems Science and Director of the California NanoSystems Institute at UCLA.

Ihor Boszko, director of business development at Xagenic, a Toronto-based in vitro diagnostics company said the breakthrough could have significant practical implications.

"This kind of highly sensitive, enzyme-free electrochemical detection technology will have tremendous utility for near patient clinical diagnostic," said Boszko. "Multiplexing of in vitro diagnostic approach adds the capability of simultaneously testing for multiple viruses or bacteria that produce similar clinical symptoms.

"It also allows for simple and cost effective manufacturing of highly multiplexed electrochemical detectors, which will certainly have a significant impact on the availability of effective diagnostic tools."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

How Many Nanoparticle-Based Drugs Reach Tumours?
“Reality check” meta-analysis reveals that only 0.7 per cent of designer nanoparticles reach their intended target.
Wednesday, April 27, 2016
‘Person-on-a-Chip’ for Drug Testing and More
Researchers at U of T Engineering have developed a new way of growing realistic human tissues outside the body.
Monday, March 14, 2016
Cancer-causing Protein “Turned Off”
Clinical trials on the horizon for experimental cancer drug.
Friday, December 04, 2015
New Gene Map Reveals Cancer’s Achilles’ Heel
Team of researchers switches off almost 18,000 genes
Tuesday, December 01, 2015
Mixed Up Cell Transportation Key Piece of ALS and Dementia Puzzle
Researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment.
Wednesday, October 07, 2015
World’s Largest Protein Interaction Map Created
A multinational team of scientists sifted through cells of vastly different organisms – from amoebae to worms to mice to humans – to reveal how proteins fit together to build different cells and bodies.
Wednesday, September 09, 2015
Why We’re Smarter Than Chickens
Toronto researchers have discovered that a single molecular event in our cells could hold the key to how we evolved to become the smartest animal on the planet.
Monday, August 24, 2015
New Chip Makes Testing For Antibiotic-Resistant Bacteria Faster, Easier
Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time.
Wednesday, May 27, 2015
Hydrogels Help Stem Cells Accelerate Healing
Scientists say they have made a breakthrough in cell transplantation using a gel-like biomaterial that keeps stem cells alive and helps them integrate better into tissue.
Monday, May 18, 2015
An end To Cancer Pain? Dentistry Researcher Finds The Pain Trigger
Study identifies TMPRSS2 as potential culprit behind the most severe forms of cancer pain.
Tuesday, April 28, 2015
Stem Cells: How to Predict Their Fate
Technique has potential for regenerative medicine and drug development.
Thursday, October 31, 2013
How Disease-Related Proteins Work; a "Truly Momentous" Discovery
Researchers are helping demystify an important class of proteins associated with disease.
Tuesday, July 09, 2013
A Recipe for Stem Cell Production
Researchers may be one step closer to a ‘recipe’ for large-scale production of stem cells for use in research and therapy.
Tuesday, July 09, 2013
A Recipe for Stem Cell Production
Researchers may be one step closer to a ‘recipe’ for large-scale production of stem cells for use in research and therapy.
Tuesday, July 09, 2013
Liver and Pancreas Precursor Cells Created using New Stem Cell Production Method
Scientists in Canada have overcome a key research hurdle to developing regenerative treatments for diabetes and liver disease.
Friday, December 02, 2011
Scientific News
Shedding Light on HIV Vaccine Design
Broadly speaking - Mathematical modelling of host-pathogen coevolution sheds light on HIV vaccine design.
AACC 2016 Sees Clinical Chemistry Labs Drive Precision Medicine Offerings
Biomarker assays to enable precision medicine and risk assessment, mass spec-based tests designed for use in clinical labs large and small, and liquid biopsy technology captured the spotlight at the AACC annual meeting.
Automated Patch Clamping Trends
Learn more about current practices, preferences and metrics in ion channel drug screening using APC technology.
Lab-on-a-Stick: Miniaturised Clinical Testing For Fast Detection Of Antibiotic Resistance
A portable power-free test for the rapid detection of bacterial resistance to antibiotics has been developed by academics at Loughborough University and the University of Reading.
Genetic Ancestry of Cultivated Strawberry Unravelled
UNH scientists constructed a linkage map of the seven chromosomes of the diploid Fragaria iinumae, which allows them to fill in a piece of the genetic puzzle about the eight sets of chromosomes of the cultivated strawberry.
Progress In Vaccination Against Vespid Venom
Researchers at the Helmholtz Zentrum München and the Technical University Munich have presented a method which facilitates a personalised procedure for wasp allergy sufferers.
New Drug Target for Inflammatory Disorders
Penn study finds enigmatic molecules maintain equilibrium between fighting infection and inflammatory havoc.
Breast Cancer Cells Found To Switch Molecular Characteristics
Spontaneous interconversion between HER2-positive and HER2-negative states could contribute to progression, treatment resistance in breast cancer.
Mechanisms of Calcium Blockers
Researchers describe how the fundamental mode of action of two distinct chemical classes of calcium channel blockers differs.
Some Breast Cancer Patients With Low Genetic Risk Could Skip Chemotherapy
Genetic test can help predict survival and guide treatment options.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!