Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

LGC Genomics and Covaris, Inc. Announce FFPE DNA Extraction Partnership

Published: Tuesday, June 25, 2013
Last Updated: Tuesday, June 25, 2013
Bookmark and Share
Companies are partnering to develop an innovative solution for the high-throughput extraction of Nucleic Acids from Formalin-Fixed, Paraffin Embedded (FFPE) tissue samples.

Covaris recently introduced a kit for high-yield DNA extraction from FFPE tissue samples. Covaris' patented Adaptive Focused Acoustic™ (AFA) Technology is used to emulsify and separate the paraffin, while simultaneously re-hydrating the tissue sample in an aqueous solution within a few minutes. Covaris Focused-ultrasonicators enable the purely mechanical processing of the samples, eliminating the need for organic solvents in the extraction process. DNA is efficiently extracted from FFPE samples with greater yield when compared to other commercially available solutions. It results in a simplified workflow, which improves reproducibility, reduces hands on time, and ensures the seamless integration with Next Generation Sequencing (NGS) and other analytical applications.
LGC Genomics has a long standing expertise in providing DNA extraction solutions, including a range of extraction technologies and the development of kits and systems optimized for specific applications. LGC Genomics' current product offerings include, sbeadex® magnetic microparticles and Kleargene spin plates for automated extraction of high quality DNA.

Building on the strengths of both companies, LGC Genomics and Covaris will integrate LGC Genomics' DNA purification solution with Covaris FFPE extraction workflow. This collaboration will offer a complete solution, from FFPE tissue to high quality DNA, suitable for high throughput applications with the ability to process thousands of FFPE samples per week.

FFPE is a widely used method for archiving tissue specimens; especially clinical samples. These archived samples are a rich resource for studying gene variations or gene expression profile changes, and have the promise of empowering advancements to clinical diagnostics and personalized medicine. However, extraction of DNA or RNA from FFPE tissue has traditionally been a challenge as it requires removing the paraffin, rehydrating the sample, and reversing the formaldehyde cross-links - resulting in low yields and poor quality of nucleic acid samples. Additionally, the traditional extraction processes require the use of hazardous or difficult-to-handle solvents causing barriers to automation and higher throughput processing. Covaris CEO, Jim Laugharn, commented, "This collaboration will provide a solution to overcome traditional short-comings and barriers. We will improve the extraction workflow and provide higher quality samples and higher quality results in a high throughput environment." Giulio Cerroni, LGC Genomics Managing Director added, "We are delighted to be working with Covaris to develop this application together. Linking our Sbeadex and Kleargene technologies with the Covaris technology will provide our customers in both pathology and research laboratories with a complete solution that will enable them to process FFPE samples significantly more efficiently, whilst also providing high yields, reproducibly."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Platelets are the Pathfinders for Leukocyte Extravasation During Inflammation
Findings from the study could help in the prevention and treatment of inflammatory pathologies.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Manufactured Stem Cells to Advance Clinical Research
Clinical-grade cell line will enable development of new therapies and accelerate early-stage clinical research.
Dengue Virus Exposure May Amplify Zika Infection
Researchers at Imperial College London have found that the previous exposure to the dengue virus may increase the potency of Zika infection.
Gender Determination in Forensic Investigations
This study investigated the effectiveness of lip print analysis as a tool in gender determination.
Identifying Novel Types of Forensic Markers in Degraded DNA
Scientists have tried to verify the nucleosome protection hypothesis by discovering STRs within nucleosome core regions, using whole genome sequencing.
Proteins in Blood of Heart Disease Patients May Predict Adverse Events
Nine-protein test shown superior to conventional assessments of risk.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Starving Stem Cells May Enable Scientists To Build Better Blood Vessels
Researchers from the University of Illinois at Chicago College of Medicine have uncovered how changes in metabolism of human embryonic stem cells help coax them to mature into specific cell types — and may improve their function in engineered organs or tissues.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!