Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Mirna Therapeutics and Horizon Discovery Uncover Important Tumor Suppressor Pathway

Published: Thursday, June 27, 2013
Last Updated: Thursday, June 27, 2013
Bookmark and Share
Paper reports new findings on tumor suppressor miR-34 relationship with p53 and p21 cancer pathways.

Mirna Therapeutics, Inc. and Horizon Discovery Ltd. announced today the publication of new data providing further confirmation that microRNA-34 (miR-34), and the tumor suppressor pathways it controls, is an important potential target for a wide variety of cancers. The data are published in Molecular Therapy, the official journal of the American Society of Gene and Cell Therapy, and reveals a novel mechanism through which miR-34 exerts its tumor suppressor function in cancers.

Mirna is currently conducting a Phase I study of MRX34, a miR-34-based therapy and the first microRNA mimic to advance into a human clinical trial. The Phase I study focuses on patients with unresectable primary liver cancer or metastatic cancer with liver involvement.
The data published in the paper entitled: “TP53-independent function of miR-34a via HDAC1 and p21CIP1/WAF1” demonstrate that the tumor suppressive activity of miR-34 is the same in p53-positive and p53-negative cancer cells. The study further revealed the existence of a p53-independent pathway by which miR-34 induces the expression of p21, a potent tumor suppressor inhibiting uncontrolled cellular proliferation. The endogenous level of p21 was shown to be critical for maximal miR-34 activity.

“The identification of an alternative pathway to induce p21 expression is a significant discovery in cancer biology with wide ranging implications for therapeutic interventions to overcome inhibition of programmed cell death,” says Andreas Bader, Ph.D., Mirna’s Director of Analytical and External Research, and senior author of the publication. “Particularly exciting is the observation that miR-34 functions similarly to p53, suggesting that miR-34 replacement therapy might represent an attractive alternative to p53-targeted therapy.”

Chris Torrance, Ph.D., Chief Scientific Officer, Horizon Discovery, said: “We were delighted to collaborate with Mirna on this project, which involved supply of X-MAN isogenic cell lines to examine the effects of specific mutations to the TP53 gene. The results are very exciting, and we look forward to seeing the outcome of Mirna’s Phase I study.”

The research was supported by a grant from the National Institutes of Health, and a commercialization grant from the Cancer Prevention and Research Institute of Texas (CPRIT).


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Mirna Therapeutics is First to Advance MicroRNA into the Clinic for Cancer
Phase 1 clinical trial of anticancer drug MRX34 underway.
Tuesday, May 14, 2013
Mirna Therapeutics Presents Preclinical Data on Lead Product Candidate
Mirna Therapeutics, Inc. announced that new preclinical data from its lead product candidate will be presented this week at the Keystone conference on Non-coding RNAs in Development and Cancer.
Thursday, January 24, 2013
Scientific News
Study Finds Brain Chemicals that Keep Wakefulness in Check
Researchers to develop new drugs that promote better sleep, or control hyperactivity in people with mania.
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!