Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Biochemical Role of Crucial TonB Protein in Bacterial Iron Transport and Pathogenesis

Published: Wednesday, July 03, 2013
Last Updated: Wednesday, July 03, 2013
Bookmark and Share
A study has discovered the role of a protein in bacteria that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery.

The results may lead to new and improved antibiotics for humans and animals.

Phillip E. Klebba, professor and head of the department of biochemistry and molecular biophysics, made the findings with two colleagues in the department: Lorne D. Jordan, doctoral candidate, Manhattan, and Salete M. Newton, research professor. The collaboration included other biophysicists at the University of Oklahoma and Purdue University. Their study, "Energy-dependent motion of TonB in the Gram-negative bacterial inner membrane," appears in the journal Proceedings of the National Academy of Sciences USA, or PNAS.

The research focuses on the central role of iron in biochemistry. Both animals and bacteria require iron for biological processes like energy generation and DNA, Klebba said. The iron acquisition systems of bacteria, however, contribute to infectious diseases.

"Iron is the object of a microbiological war in the human body," Klebba said. "Host proteins defend cells and tissues by sequestering the metal, and successful pathogens overcome this barrier and capture the iron. But the iron transport mechanisms of pathogenic organisms are not well understood."

The membrane protein TonB plays an indispensable role in the uptake of iron by Gram-negative bacteria -- a classification of bacteria that is more resistant to antibiotics because of a nearly impenetrable cell wall. Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.

Despite decades of research, the biochemical role of TonB in Gram-negative bacteria was a scientific mystery, Klebba said. He and his colleagues found that the cellular electrochemical forces put TonB in a spinning motion that provides the energy and physical mechanism to enable iron uptake into the cell.

"In this sense TonB acts like an electric motor that constantly rotates in response to the cellular energy flow," Klebba said. "TonB is one of nature's smallest and oldest electrical devices."


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genomics Can Match Plant Variety to Climate Stresses
A new study on the genomic signatures of adaptation in crop plants can help predict how crop varieties respond to stress from their environments.
Friday, July 10, 2015
Vaccines Developed for H5N1, H7N9 Avian Influenza Strains
Vaccines have been developed for H5N1 and H7N9, two emerging strains of avian influenza. The strains are zoonotic and can be transmitted from chickens to pigs and humans.
Tuesday, May 26, 2015
Spring Heat More Damaging to Wheat than Fall Freeze
Scientists need to develop new heat-resistant wheat varieties.
Friday, May 15, 2015
Detailed Genetic Map of World Wheat Varieties Developed
Kansas State University researchers are releasing a study that details the first haplotype map of wheat.
Tuesday, March 24, 2015
Resistance Gene Found Against Ug99 Wheat Stem Rust Pathogen
The world's food supply got a little more plentiful thanks to a scientific breakthrough.
Wednesday, July 03, 2013
Controlling Plant Parasitic Nematodes
A recently patented invention from a Kansas State University research team aims to control a devastating parasite that causes millions of dollars in crop damage each year.
Wednesday, November 17, 2010
Study Finds Media May be Overhyping Benefits of Organic Food, Agriculture
News accounts of organic agriculture and organic food are more likely to be positive than negative and inaccurately claim organic food is safer
Monday, July 26, 2010
Scientific News
Study Finds Brain Chemicals that Keep Wakefulness in Check
Researchers to develop new drugs that promote better sleep, or control hyperactivity in people with mania.
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!