Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Cancer-Linked Fam190a Gene Found to Regulate Cell Division

Published: Monday, July 08, 2013
Last Updated: Monday, July 08, 2013
Bookmark and Share
A little-described gene known as FAM190A plays a subtle but critical role in regulating the normal cell division process known as mitosis.

In laboratory studies of cells, investigators found that knocking down expression of FAM190A disrupts mitosis. In three pancreatic cancer-cell lines and a standard human-cell line engineered to be deficient in FAM190A, researchers observed that cells often had difficulty separating at the end of mitosis, creating cells with two or more nuclei. The American Journal of Pathology published a description of the work online May 17, which comes nearly a century after German scientist Theodor Boveri linked abnormal mitosis to cancer. Until now, there had been no common gene alteration identified as the culprit for cancer-linked mitosis.

“These cells try to divide, and it looks like they succeed, except they wind up with a strand that connects them,” explains Scott Kern, M.D., professor of oncology and pathology at Johns Hopkins University School of Medicine and its Kimmel Cancer Center. “The next time they try to divide, all the nuclei come together, and they try to make four cells instead of two. Subsequently, they try to make eight cells, and so on.” Movies of the process taken by Kern’s laboratory are available on the journal Web site.

Kern’s group previously reported that deletions in the FAM190A gene could be found in nearly 40 percent of human cancers. That report, published in 2011 in the journal Oncotarget, and the current one are believed to be the only published papers focused solely on FAM190A, which is frequently altered in human cancers but whose function has been unknown. Alterations in FAM190A messages may be the third most common in human cancers after those for the more well-known genes p53 and p16, Kern says.

“We don’t think that a species can exist without FAM190, but we don’t think severe defects in FAM190A readily survive among cancers,” Kern says. “The mutations seen here are very special – they don’t take out the whole gene but instead remove an internal portion and leave what we call the reading frame. We think we’re finding a more subtle defect in human cancers, in which mitosis defects can occur episodically, and we propose it may happen in about 40 percent of human cancers.”

Abnormalities in FAM190A may cause chromosomal imbalances seen so commonly in cancers, Kern says. Multipolar mitosis is one of the most common functional defects reported in human cancers, and more than 90 percent of human cancers have abnormal numbers of chromosomes.

Kern says he plans to study FAM190A further by creating lab models of the subtle defects akin to what actually is tolerated by human cancer cells.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Paternal Sperm May Hold Clues to Autism
Tags on DNA from fathers’ sperm linked to children’s autism symptoms.
Friday, April 17, 2015
New Autism-Causing Genetic Variant Identified
Novel approach expected to be useful for other diseases too.
Saturday, March 28, 2015
Bad Luck of Random Mutations Plays Predominant Role in Cancer, Study Shows
Statistical modeling links cancer risk with number of stem cell divisions.
Tuesday, January 06, 2015
Enzyme's Alter Ego Helps Activate the Immune System
Findings could shed light on related Alzheimer's protein.
Tuesday, January 06, 2015
Researchers Tease Out Glitches in Immune System's Self-Recognition
A new study revises understanding of how the process works and sheds light on autoimmune disease.
Saturday, November 22, 2014
Cancer Leaves a Common Fingerprint on DNA
Chemical alterations to genes appear key to tumor development.
Tuesday, August 26, 2014
Researchers Use Human Stem Cells to Create Light-Sensitive Retina in a Dish
Johns Hopkins researchers have created a 3-D complement of human retinal tissue in the laboratory.
Saturday, June 14, 2014
Signals Found That Recruit Host Animals’ Cells, Enabling Breast Cancer Metastasis
Mouse studies suggest that blocking aid from white blood cells and stem cells could keep tumors contained.
Thursday, May 22, 2014
Common Genetic Pathway Could Be Conduit to Pediatric Tumor Treatment
Investigators have found a known genetic pathway to be active in many difficult-to-treat pediatric brain tumors called low-grade gliomas.
Monday, November 11, 2013
A Simple Blood Test May Catch Early Pancreatic Cancer
Currently, disease usually found too late to save lives.
Wednesday, October 30, 2013
New Testing Strategy Detects Population-Wide Vitamin and Mineral Deficiencies
Could speed mass intervention in developing countries.
Wednesday, October 30, 2013
Stem Cells may do Best with a Little Help from their Friends
“Helper cells” improve survival rate of transplanted stem cells, mouse study finds.
Wednesday, September 11, 2013
Molecular Marker Predicts Patients Most Likely to Benefit Longest From Two Popular Cancer Drugs
Preliminary study needs further confirmation.
Wednesday, September 11, 2013
Discovery Increases Diagnostic Certainty and Opportunity for Individualized Drug Therapy
Of the over 1,900 errors already reported in the gene responsible for CF, it is unclear how many of them actually contribute to the inherited disease.
Thursday, August 29, 2013
Crucial Brain-Signaling Molecule Requires Coordinated Motion to Turn On
Study could help yield new drugs for brain disorders.
Monday, August 12, 2013
Scientific News
Genetic Defences of Bacteria Don’t Aid Antibiotic Resistance
Genetic responses to the stresses caused by antibiotics don’t help bacteria to evolve a resistance to the medications, according to a new study by Oxford University researchers.
Detecting HIV Diagnostic Antibodies with DNA Nanomachines
New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and auto-immune diseases such as rheumatoid arthritis and HIV.
Snapshot Turns T Cell Immunology on its Head
New research may have implications for 1 diabetes sufferers.
Tolerant Immune System Increases Cancer Risk
Researchers have found that individuals with high immunoCRIT ratios may have an increased risk of developing certain cancers.
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
New Approach to Treating Heparin-induced Blood Disorder
A potential treatment for a serious clotting condition that can strike patients who receive heparin to treat or prevent blood clots may lie within reach by elucidating the structure of the protein complex at its root.
Horse Illness Shares Signs of Human Disease
Horses with a rare nerve condition have similar signs of disease as people with conditions such as Alzheimer’s, a study has found.
How a Molecular Motor Untangles Protein
Diseases such as Alzheimer’s, Parkinson’s and prion diseases, all involve “tangled” proteins.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos