Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

A Recipe for Stem Cell Production

Published: Tuesday, July 09, 2013
Last Updated: Tuesday, July 09, 2013
Bookmark and Share
Researchers may be one step closer to a ‘recipe’ for large-scale production of stem cells for use in research and therapy.

Induced pluripotent stem cells (iPSCs) can be of great value for medical research because they can flexibly develop into many different types of cells. However, producing these cells is challenging because the proteins that control their generation are largely unknown.                                                       

But researchers from the University of Toronto, the Hospital for Sick Children and Mount Sinai Hospital (with colleagues from the United States and Portugal) say they have identified certain proteins that play a key role in controlling pluripotency, which may mean a potential breakthrough in producing these cells.

The findings were recently published in Nature. One of the authors is Professor Brendan Frey (ECE). He said the researchers discovered the proteins using the splicing code developed a few years ago by a team led by he and U of T Donnelly Centre researcher Benjamin Blencowe. “The mechanisms that control embryonic stem cell pluripotency have remained a mystery for some time. However, what Dr. Blencowe and the research team found is that the proteins identified by our splicing code can activate or deactivate stem cell pluripotency,” Frey said.

When asked why the identification of these proteins is important, Frey gave the following analogy: “Suppose you've tasted many wonderful gourmet dishes, but you have absolutely no idea what's needed to make them. Then, one day, you discover that there's something called a ‘measuring cup’ that is used by all of the gourmet chefs. Now you understand something important about how dishes are prepared, and you also know about a ‘control knob’ that can be turned in order to make different dishes, just as adjusting the amount of butter and flour will give a different kind of pastry.”

And while a complete recipe for producing iPSCs may not be available yet, Frey said, it’s beginning to look more likely.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

How Many Nanoparticle-Based Drugs Reach Tumours?
“Reality check” meta-analysis reveals that only 0.7 per cent of designer nanoparticles reach their intended target.
Wednesday, April 27, 2016
‘Person-on-a-Chip’ for Drug Testing and More
Researchers at U of T Engineering have developed a new way of growing realistic human tissues outside the body.
Monday, March 14, 2016
Cancer-causing Protein “Turned Off”
Clinical trials on the horizon for experimental cancer drug.
Friday, December 04, 2015
New Gene Map Reveals Cancer’s Achilles’ Heel
Team of researchers switches off almost 18,000 genes
Tuesday, December 01, 2015
Mixed Up Cell Transportation Key Piece of ALS and Dementia Puzzle
Researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment.
Wednesday, October 07, 2015
World’s Largest Protein Interaction Map Created
A multinational team of scientists sifted through cells of vastly different organisms – from amoebae to worms to mice to humans – to reveal how proteins fit together to build different cells and bodies.
Wednesday, September 09, 2015
Why We’re Smarter Than Chickens
Toronto researchers have discovered that a single molecular event in our cells could hold the key to how we evolved to become the smartest animal on the planet.
Monday, August 24, 2015
New Chip Makes Testing For Antibiotic-Resistant Bacteria Faster, Easier
Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time.
Wednesday, May 27, 2015
Hydrogels Help Stem Cells Accelerate Healing
Scientists say they have made a breakthrough in cell transplantation using a gel-like biomaterial that keeps stem cells alive and helps them integrate better into tissue.
Monday, May 18, 2015
An end To Cancer Pain? Dentistry Researcher Finds The Pain Trigger
Study identifies TMPRSS2 as potential culprit behind the most severe forms of cancer pain.
Tuesday, April 28, 2015
Stem Cells: How to Predict Their Fate
Technique has potential for regenerative medicine and drug development.
Thursday, October 31, 2013
How Disease-Related Proteins Work; a "Truly Momentous" Discovery
Researchers are helping demystify an important class of proteins associated with disease.
Tuesday, July 09, 2013
A Recipe for Stem Cell Production
Researchers may be one step closer to a ‘recipe’ for large-scale production of stem cells for use in research and therapy.
Tuesday, July 09, 2013
University of Toronto Breakthrough Allows Fast, Reliable Identification of Pathogens
Researchers have created an electronic chip that can analyze blood and other clinical samples for infectious bacteria with record-breaking speed.
Friday, June 21, 2013
Liver and Pancreas Precursor Cells Created using New Stem Cell Production Method
Scientists in Canada have overcome a key research hurdle to developing regenerative treatments for diabetes and liver disease.
Friday, December 02, 2011
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
A Diversity of Genomes
New DNA from understudied groups reveals modern genetic variation, ancient population shifts.
“Sixth Sense” May Be More Than Just A Feeling
The NIH Study shows that two young patients with a mutation in the PIEZ02 have problems with touch and proprioception, or body awareness.
Gene Could Reduce Female Mosquitoes
Virginia Tech researchers have found a gene that can reduce female mosquitoes over many generations.
Biomolecular Manufacturing ‘On-the-Go’
Wyss Institute team unveils a low-cost, portable method to manufacture biomolecules for a wide range of vaccines, other therapies as well as diagnostics.
Improving Crop Efficiency with CRISPR
New study of CRISPR-Cas9 technology from Virginia Tech shows potential to improve crop efficiency.
Fighting Cancer with Sticky Nanoparticles
Treatment that uses bioadhesive nanoparticles drug carriers proved more effective than conventional treatments for certain cancers.
Stem Cell ‘Heart Patch’ Almost Perfected
Scientists aiming to perfect and test 3D "heart patches" in animal model, last hurdle before human patients.
Fighting Plant Pathogens with RNA
Researchers develop strategy that could lead to environmentally friendly fungicide to fight pathogens.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!