Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Discovered a Future Therapeutic Target for Lung Cancer Treatment

Published: Monday, July 22, 2013
Last Updated: Monday, July 22, 2013
Bookmark and Share
One of the goals of research in cancer genetics and molecular biology is to get an "on demand" treatment, with maximum effect and minimal toxicity.

Two recent examples in this field are the findings that lung cancer patients carrying mutations in EGFR and ALK are more sensitive to certain drugs with tyrosine kinase inhibitory activity. The problem is that few cancer patients show the aforementioned genetic defects susceptible to be treated with the new drugs.

The magazine Oncogene has published an article ed by Manel Esteller, Director of Epigenetics and Cancer Biology Biomedical Research Institute (IDIBELL), ICREA researcher and Professor of Genetics at the University of Barcelona, which describes a new genetic alteration an oncogene in lung cancer that could be a good candidate for the development of specific drugs.

"We found that in 5-10% of lung tumors, instead of having normal dose of  oncogene (two copies, one on the maternal chromosome and one on the paternal) have an overdose of it, about 10 copies gene pool "explained Manel Esteller, director of the study.

The new identified oncogene originates the protein called SETDB1, a histone methyltransferase. It is an enzyme which can be inhibited by compounds in which drug industry has experience.

"Our study," explained Esteller "indicates a weakness of the defensive wall of the tumor cell and it has been possible to detect through the European project CURELUNG . Now we would like some pharmaceutical company follow this line of research in the future availability of an applicable drug in patients".

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Keeping Growth in Check
Ribosomal proteins RPL5 and RPL11 play an essential role in normal cell proliferation.
Friday, December 13, 2013
Key Role of a Protein in the Segregation of Genetic Material During Cell Division
Researchers at IDIBELL have reported an article which delves into the regulator mechanisms of mitosis.
Wednesday, December 11, 2013
Discovered a Mechanism that Induces Migration of Tumor Cells in Liver Cancer
Coordinated overactivation of TGFb and CXCR4 signaling pathways confer migratory properties to the hepatocellular carcinoma cells.
Wednesday, November 06, 2013
The European Union Allocates Six Million Euros to Study Prevention Strategies Tumors Caused by HPV
The human papillomavirus (HPV) is responsible for cervical cancer and is behind a significant percentage of other tumors such as vulva , vagina, penis, anus, and oropharynx.
Tuesday, November 05, 2013
Researchers Discover the Genetic Signature of Highly Aggressive Small Lung Tumors
A study conducted by the IDIBELL allows to identify this type of cancer at an early stage and adapt the treatment.
Thursday, October 03, 2013
Discovered Epigenetic Alterations in the Brain of Alzheimer's Patients
Alzheimer disease is becoming a major health problem in Western societies, exacerbated by the progressive aging of the population.
Monday, September 16, 2013
High Levels of RANK Protein Interferes with the Differentiation of Mammary Cells
Levels of this protein increase with age, which could explain the increase in breast cancer risk associated with age.
Wednesday, September 11, 2013
The Epigenome Differentiates the Different Human Populations
Establishing what differentiates us from our neighbors, our friends or strangers from distant countries.
Monday, August 05, 2013
Patented, a Molecule that Opens the Door to Develop New Drugs Against Immune Rejection
Researchers have patented a peptide that inhibits the immune response activated by the enzyme calcineurin which could serve to develop new more specific immunosuppressive drugs.
Thursday, August 01, 2013
Brain Epigenome Changes from Birth to Adolescence
Experience of parents with their children and teachers with their students demonstrate how kids change their behaviours and knowledge from childhood to adolescence.
Friday, July 05, 2013
Discovered the Role of Noncoding 5S rRNA in Protecting the p53 Tumor Suppressor Gene
Over 50% of tumors are associated with mutations in p53.
Thursday, July 04, 2013
A Gene Conserved from Worms to Humans Opens the Door to new Therapeutics
Gene shows promising therapeutic strategies in cancer and in some types of blindness.
Friday, June 21, 2013
Genetically Modified Stem Cells are Effective Against Acute Respiratory Diseases
Administration of genetically modified mesenchymal stem cells regenerates lung tissue and stops the inflammatory process in mice with acute lung injury.
Tuesday, June 18, 2013
An Epigenetic Change Causes the Block of Antitumor Genes
Healthy cells live in a delicate balance between growth-promoting genes (oncogenes) and those who restrain it (anti-oncogenes or tumor suppressor genes).
Wednesday, June 12, 2013
A Diabetes Drug, a Promising Treatment for Neurodegenerative Disease
Pioglitazone slows neurodegeneration and impaired locomotor system affected by X-linked adrenoleukodystrophy.
Tuesday, June 11, 2013
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Fat Cells Originating from Bone Marrow Found in Humans
Cells could contribute to diabetes, heart disease.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos