Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Flow Methodology for Highly Reproducible Bromination Reactions

Published: Monday, July 29, 2013
Last Updated: Monday, July 29, 2013
Bookmark and Share
Uniqsis FlowSyn™ - Designed for easy, safe and efficient operation.

Uniqsis has announced an application note that describes a continuous flow methodology for electrophilic bromination that offers excellent control of both temperature and mixing using a proprietary mixer chip, leading to a highly reproducible outcome.

Electrophilic bromination is a useful reaction in organic synthesis. However, when molecular bromine is used as the electrophile, under acidic conditions, it can be difficult to control both the exothermic addition and to prevent subsequent bis-bromination of the desired monobrominated product.

In application note 21 - the authors demonstrate that using a static mixer chip on a FlowSyn flow chemistry system to control both mixing and temperature - bromination becomes a titration and the reaction can be performed rapidly under elevated temperatures.

The bromination could be performed in a coil reactor however the short reaction time of 30 seconds at 70°C makes it better suited to implementation in a chip.

The authors suggest how the chip based bromination methodology could be straightforwardly scaled to 28g / hour by connecting a 5 ml HT-PTFE coil reactor in line with the mixer chip and increasing the flow rate to 13.2 ml/min.

The Uniqsis FlowSyn™ is a compact integrated continuous flow reactor system designed for easy, safe and efficient operation.

The FlowSyn™ range includes models for performing single or multiple homogeneous or heterogeneous reactions, either manually or automatically.

The range of chemistries that can be explored with Uniqsis’ integrated and modular flow chemistry systems grows ever wider and is exemplified by the growing number of applications published both in the academic press and in Uniqsis’ own application notes.

Typical examples of flow chemistry applications include hydrogenation, nitration, bromination, metalation, molecular rearrangements and synthesis of compounds suchas dihyropyridine, indole, pyrazole, quinolinone and benzimidazole.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Cambridge Reactor Design and Uniqsis Announce Joint Marketing Agreement
The companies have entered into a joint marketing agreement for the Gastropod gas introduction module and the Polar Bear low temperature reactor, for flow chemistry applications.
Monday, April 18, 2011
Flow Chemistry Company Moves Ahead
Significant developments have been reported by Uniqsis to develop a new concept in flow chemistry, leading to the launch of the FlowSyn™ Continuous Flow Reactor at the end of last year.
Monday, January 14, 2008
Microreaction System Nears Launch
Uniqsis Ltd. has announced major progress towards launching FlowSyn™ later in the year.
Wednesday, August 15, 2007
Scientific News
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Genetic Cause of Rare Allergy
Institute has identified a genetic mutation responsible for a rare form of inherited hives induced by vibratory urticaria.
Battery Component Found to Harm Key Soil Microorganism
The material at the heart of the lithium ion batteries that power electric vehicles, laptop computers and smartphones has been shown to impair a key soil bacterium, according to new research.
Keeping Tumor Growth at Bay
Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets.
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Validating the Accuracy of CRISPR-Cas9
IBS Researchers create multiplex Digenome-seq to find errors in CRISPR-Cas9 processes.
Cancer Drug Target Visualized at Atomic Resolution
New study using cryo-electron microscopy shows how potential drugs could inhibit cancer.
Genetic Mechanism Behind Cancer-Causing Mutations
Researchers at Indiana University has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!