Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New AB SCIEX Software Accelerates Drug Screening for Clinical Research Laboratories

Published: Wednesday, July 31, 2013
Last Updated: Wednesday, July 31, 2013
Bookmark and Share
Software expands possibilities in clinical research with speed and precision of accurate mass technology.

AB SCIEX has announced the availability of MPX™ TF 1.0 Software to accelerate drug screening with accurate mass-based technology for laboratories performing clinical research.

The new software is designed to deliver faster turnaround times, increased sample throughput and lower costs compared to single-stream, mass spectrometry (MS) methods.

This new software will be showcased to researchers at the American Association for Clinical Chemistry (AACC) conference in Houston, Texas this week.

With the new MPX TF Software, researchers are now able to increase throughput by as much as twofold. This is made possible by enabling the use of two parallel liquid chromatography streams.

The ability to stagger chromatographic runs while collecting sample data allows the use of instrument "dead time" to increase the number of samples run in a given time period. This means identifying more compounds in a shorter period of time.

By combining the increased throughput of the MPX software with the capability of the AB SCIEX TripleTOF® 4600 accurate mass system to produce reliable data for a large number of compounds, researchers will be able to do more in less time compared to single-stream MS methods while significantly reducing rates of false positives and false negatives, thanks to LC separation of potential interferences and the enhanced specificity of high-resolution accurate mass technology.

Among the researchers who are using accurate mass technology is Dr. Kara Lynch, PhD. from the University of California, San Francisco (UCSF). She uses a TripleTOF platform to identify unknown compounds, complementing the targeted analysis she does with triple quadrupole instrumentation.

“As the list of drugs and their metabolites are always changing, the value of high resolution, accurate mass technology is identifying unknowns with high specificity,” said Dr. Lynch at UCSF. “Accurate mass-based analysis with a TripleTOF system helps identify compounds that could be missed in a targeted approach if a certain drug is not in the original method. Furthermore, with this technology, you are able to re-interrogate the data at a later date to answer new questions, without needing to re-run the samples.”

AB SCIEX is committed to providing the tools to enable the adoption of accurate mass technology in clinical research laboratories.

By applying MS/MS on an accurate mass system, clinical researchers can take advantage of the enhanced specificity of compound-specific MS/MS fragmentation. This enables more confident compound identification, including ID of unknown compounds, such as new ‘designer’ drugs.

“AB SCIEX continues to drive innovation in clinical research to address existing issues, such as slow turnaround times and false positives or negatives, which hinder these labs from increasing productivity and improving data quality,” said Rainer Blair, President of AB SCIEX. “We are helping clinical research labs reshape how they conduct drug screening to accurately identify not only known but also unknown compounds.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

SCIEX and New Objective Announce Partnership
New nanospray sources to offer maximum sensitivity and robustness for NanoLC-MS.
Tuesday, June 02, 2015
SCIEX and New Objective Partner
Partnership will provide advanced nanospray ionization technologies for next-generation proteomics.
Tuesday, May 26, 2015
SCIEX and Hepregen Announce Co-Marketing Agreement
Alliance establishes SCIEX and Hepregen as a one-stop solution provider for drug metabolism investigators.
Friday, May 22, 2015
Sciex, Hepregen Team up on Metabolite Identification Offering
This recently announced collaboration aims to provide practical solutions for drug metabolism researchers.
Thursday, May 21, 2015
Dr. Gyula Vigh wins Arnold O. Beckman Award
SCIEX sponsored award recognizes outstanding contributions to the field of electrodriven separation techniques.
Thursday, May 07, 2015
SCIEX and Mass Consortium Corporation Announce Exclusive Reseller Agreement
SCIEX to provide customers with XCMSplus software solution for simplified and accelerated metabolomics workflows.
Tuesday, March 31, 2015
SCIEX Announces OneOmics™ Collaborators
Advaita Bioinformatics, Researchers at Yale University and ISB launch applications and libraries that combine next-generation proteomics and next-generation sequencing data in innovative ways.
Thursday, March 19, 2015
SCIEX and Labor Berlin Collaboration to Advance Forensic Testing
Collaboration for the development of a hybrid Quadrupole Time-of-Flight (TOF) MS/MS reference library.
Thursday, March 05, 2015
New Capabilities for Bioanalysis Studies at the International Pharmaceutical Research Center
AB SCIEX Triple Quad™ 6500 LC/MS/MS systems enable new levels of sensitivity for clinical trials of inhaled drugs.
Wednesday, February 11, 2015
Improved Accuracy of Pesticide Detection in Food
European Reference Laboratory improves accuracy of pesticide detection in food with AB SCIEX mass spectrometry instrumentation.
Wednesday, February 04, 2015
AB SCIEX Wins New Product Innovation Award in Asia Pacific
The award recognizes the company’s continued innovation in the mass spectrometry industry and a number of new products introduced into the market in recent years.
Thursday, October 30, 2014
AB SCIEX Scientist Wins HUPO 2014 Science and Technology Award
Winner becomes second team member to be recognized for the commercialization of transformative chemistries such as iTRAQ® eagents.
Monday, October 06, 2014
AB SCIEX, Illumina Collaborate to Create Multi-omics Cloud-Computing Environment
Integration of SWATH™ Apps with BaseSpace® brings next-generation proteomics and next-generation sequencing together for the first time.
Thursday, October 02, 2014
AB SCIEX and Dalton Collaborate to Advance ADC Analysis
Collaboration supports movement to develop targeted anti-body based therapies.
Friday, August 29, 2014
AB SCIEX, Dalton Pharma Services Announce ADC Partnership
Research collaboration aims to develop Antibody-Drug Conjugate analysis capabilities.
Wednesday, August 27, 2014
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
Investigating the Vape
Expert independent review concludes that e-cigarettes have potential to help smokers quit.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Researchers Discover Synthesis of a New Nanomaterial
Interdisciplinary team creates biocomposite for first time using physiological conditions.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!