Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Dentistry School Receives $5M to Study Saliva Biomarkers

Published: Thursday, August 15, 2013
Last Updated: Thursday, August 15, 2013
Bookmark and Share
Imagine having a sample of your saliva taken at the dentist's office, and then learning within minutes whether your risk for stomach cancer is higher than normal.

The UCLA School of Dentistry received $5 million in funding from the National Institutes for Health to study biological markers in saliva to attempt to develop a tool for detecting stomach cancer. The study has the potential to create a new paradigm in the field of salivary diagnostics, and it could supply concrete evidence that saliva can be used in the detection of life-threatening diseases, including diabetes and cancers of the pancreas, breasts, ovaries and stomach.

The award comes from the NIH Common Fund, a program established to overcome obstacles in biomedical research that have hindered scientific discovery and its translation into improved human health. The funding awarded to the School of Dentistry comes from the Common Fund's Extracellular RNA Communication initiative, which has awarded leading research institutes around the world a total of $160 million to address the transformative potential of the emerging field of salivary diagnostics.

Leading UCLA's five-year project is Dr. David Wong, a pioneer in the field of salivary diagnostics, the dentistry school's associate dean of research, and the Felix and Mildred Yip Endowed Professor in Dentistry. His team will develop and definitively validate salivary extracellular ribonucleic acid (exRNA) biomarkers for stomach cancer detection.

Conventionally, RNA - which translates genetic code from DNA to make protein - was always believed to reside within cells. However, scientists have recently found that RNA is secreted into extracellular spaces, or spaces outside the cell. Researchers surmised that exRNA acts as an exocrine signal, a signal that travels by way of a duct, to alter the cell traits of target cells. This messaging system occurs in the body's central organs, such as the stomach and heart, and in the extremities, such as the fingers, toes and mouth.

With the Common Fund award, Wong's team will conduct a prospective study to develop a salivary biomarker panel that would definitively validate for stomach cancer detection. Their hope is to capture exRNAs in saliva samples secreted by stomach cancer cells to confirm whether the patient is at risk for stomach cancer.

"Salivary diagnostics is a very dynamic field with a lot of potential and I am excited that our research is advancing toward clinical maturation," Wong said. "The National Institutes for Health's support for developing salivary exRNA biomarkers as part of the Common Fund initiative is a strong statement that saliva is scientifically credible for the detection of systemic disease."

Wong's laboratory, along with collaborators, first discovered salivary exRNA molecules in 2004 and demonstrated their translational utility for detecting oral cancer. Over the next several years, the team developed salivary exRNA biomarkers for a number of oral and systemic diseases, including salivary gland tumors, Sjögren's syndrome and many life-threatening cancers. While there are other diagnostic constituents in saliva, salivary exRNAs are the most reliable markers for disease.

This NIH Common Fund initiative highlights the transformative potential of biological information revealed in exRNAs towards the regulation of health and diseases. Moreover, it echoes President Barrack Obama's Strategy for American Innovation to address the so-called Grand Challenges of the 21st century. High on the list of those challenges is the goal of "early detection of dozens of disease from a saliva sample."

"UCLA is uniquely poised to advance the basic, translational and clinical sciences of salivary diagnostics," said Dr. No-Hee Park, dean of the UCLA School of Dentistry. "A new landscape of saliva biology is on the horizon."

The research will be conducted in collaboration with Dr. Sung Kim, executive vice president and director of gastric cancer at the Samsung Medical Center in Seoul, Korea; Dr. David Chia, a professor in the department of pathology at the David Geffen School of Medicine at UCLA; Dr. David Elashoff, a professor in the department of biostatistics at the UCLA Fielding School of Public Health; and Dr. Yong Kim, an associate professor in the division of oral biology and medicine at the UCLA School of Dentistry.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Ultrafast DNA Diagnostics
New technology developed by UC Berkeley bioengineers promises to make a workhorse lab tool cheaper, more portable and many times faster by accelerating the heating and cooling of genetic samples with the switch of a light.
Monday, August 03, 2015
Scientists Create CRISPR/Cas9 Knock-In Mutations in Human T Cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
Tuesday, July 28, 2015
Simple Technology Makes CRISPR Gene Editing Cheaper
University of California, Berkeley, researchers have discovered a much cheaper and easier way to target a hot new gene editing tool, CRISPR-Cas9, to cut or label DNA.
Friday, July 24, 2015
Printed "Smart Cap" Detects Spoiled Food
It might not be long before consumers can just hit “print” to create an electronic circuit or wireless sensor in the comfort of their homes.
Tuesday, July 21, 2015
Growing Spinal Disc Tissue
Scientists develop new method for growing spinal disc tissue in the lab for combating chronic back pain.
Friday, July 03, 2015
Delivering Drugs to the Right Place
Thomas Weimbs has developed a targeted drug delivery method that could potentially slow the progression of polycystic kidney disease.
Monday, June 29, 2015
The Deep Carbon Cycle
Over billions of years, the total carbon content of the outer part of the Earth—in its upper mantle, crust, oceans and atmospheres—has gradually increased, scientists report.
Tuesday, June 23, 2015
Designing New Pain Relief Drugs
Researchers have identified the molecular interactions that allow capsaicin to activate the body’s primary receptor for sensing heat and pain, paving the way for the design of more selective and effective drugs to relieve pain.
Thursday, June 11, 2015
Engineers Crack DNA Code of Autoimmune Disorders
Researchers have identified an unexpectedly general set of rules that determine which molecules can cause the immune system to become vulnerable to the autoimmune disorders lupus and psoriasis.
Wednesday, June 10, 2015
Genetic Markers for Detecting and Treating Ovarian Cancer
Custom bioinformatics algorithm identifies human mRNAs that distinguish ovarian cancer cells from normal cells and provide new therapeutic targets
Wednesday, May 27, 2015
Researchers Reverse Bacterial Resistance to Antibiotics
Evidence continues to surface that supports the premise that antibiotics which have been out of use could still be effective in treating drug-resistant bacteria.
Friday, May 08, 2015
Industry-Sponsored Academic Inventions Spur Increased Innovation
Analysis questions assumption that corporate support skews science toward inventions that are less useful than those funded by the government or non-profit organizations.
Monday, March 24, 2014
May the Cellular Force be With You
Like tiny construction workers, cells sculpt embryonic tissues and organs in 3D space.
Friday, December 13, 2013
Grant Supports Creation of Patient-Derived Stem Cell Lines
Researchers have received a two-year, $600,000 grant from the National Institute on Aging to develop and study patient-derived stem cell lines.
Thursday, December 12, 2013
Prostate Cancer Stem Cells are a Moving Target
Researchers have discovered how prostate cancer stem cells evolve as the disease progresses, a finding that could help point the way to more highly targeted therapies.
Friday, December 06, 2013
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
Investigating the Vape
Expert independent review concludes that e-cigarettes have potential to help smokers quit.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Researchers Discover Synthesis of a New Nanomaterial
Interdisciplinary team creates biocomposite for first time using physiological conditions.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!