Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Propose a Molecular Explanation for Degenerative Disease

Published: Monday, August 19, 2013
Last Updated: Monday, August 19, 2013
Bookmark and Share
An international collaboration has shed new light on the origins and molecular causes of age related degenerative conditions including Motor Neurone Disease (MND).

The new perspective provided by this work may lead the way to new treatments and early diagnoses.

The article which has just been published in the leading peer reviewed, international journal Cell, offers new opportunities for early diagnosis of age related degenerative diseases before symptoms appear, including through the identification of disease causing genes. It also suggests specific strategies for developing therapies which might have both preventative and therapeutic benefits for this class of degenerative disease.

Commenting on the significance of the findings co-lead author Professor Mani Ramaswami, Professor of Neurogenetics at the School of Genetics and Microbiology, Trinity College Dublin said: “Degenerative diseases, such as MND, are a poorly understood and largely untreatable set of life limiting diseases which can leave people unable to do the everyday things that the rest of us, particularly the young, take for granted. These age-associated diseases have far-reaching socioeconomic impacts. If you can predict the disease you may be in a position to slow down its onset and progression through therapeutic interventions. With these types of diseases this is significantly more effective than trying to treat the condition once symptoms have appeared. The potential for early diagnosis and delaying the onset of motor or cognitive decline by perhaps ten years is of potentially profound importance in an ageing society.”

There are nearly 120,000 cases of MND diagnosed worldwide each year with about 300 people in Ireland living with the disease at any one time.

The research just published proposes that the normal biology of mRNA regulation in neurones, in which RNA is generally silenced and only activated in the correct place and time, makes it susceptible to both age-related decline and disturbance by genetic mutation. Altered RNA regulation (ribostasis), therefore, may be a frequent causative factor in degenerative disease.  While normal RNA regulation involves regulated and reversible assembly of RNA-protein particles, both increased cellular age and mutation push the process towards hyperassembly, which leads to altered pools of RNA or RNA regulatory proteins in neurones that contribute to their eventual death.

Co-authors of the publication, Professors Ramaswami, Taylor (St. Jude Children’s Research Hospital, Memphis) and Parker (University of Colorado)* have based their model on a synthesis of findings from their collaborations and recent work by their individual research groups.

Research on neuronal RNA regulation in Professor Ramaswami's lab is funded by Science Foundation Ireland and benefits from collaborations with the National Centre for Biological Sciences Bangalore.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Blueprinting Cell Membrane Proteins
Recent breakthrough will make the blueprinting process faster, easier and cheaper, and should have major implications in the field of drug discovery and development.
Monday, June 08, 2015
Inflammation Stops The Clock
Researchers at Trinity College Dublin and the University of Pennsylvania have uncovered an important link between our body clock and the immune system that will have relevance to the treatment of inflammatory and infectious diseases.
Wednesday, May 20, 2015
Grazing Animals ‘Rescue’ Biodiversity Threatened by Fertiliser
Damaging impacts of fertiliser offset by herbivorous grazers, whose actions enhance the amount of sunlight available to lots of precious species.
Monday, March 10, 2014
Fertilization Destabilizes Grassland Ecosystems on a Global Scale
Collaborative research across five continents shows that fertilization drives the same damaging patterns seen in different grassland ecosystems across the planet.
Tuesday, February 18, 2014
New Cloud Computing System that can Reduce Carbon Emissions
The ‘Stratus’ system shares server load to meet green and cost-related goals of companies.
Wednesday, January 15, 2014
Scientists Discover Genetic Basis for Memory Formation with Implications for Neurological Diseases
Two genes linked to simple memory formation also regulate appropriate nerve responses that are lacking in related disease sufferers.
Monday, December 23, 2013
Elliot Meyerowitz Receives Trinity College Dublin Dawson Prize in Genetics
World-renowned plant biologist honoured for his contribution to genetics at Trinity.
Monday, December 09, 2013
Genetic Mutation Could Increase Understanding of ADHD
Absence of normal gene that expresses a protein involved in nerve cell communication results in seizures and hyperactivity.
Wednesday, November 27, 2013
International Research Project Identifies a New Genetic Mutation that Helps Explain the Development of Eczema
Scientists have identified a new genetic mutation linked to the development of a type of eczema known as atopic dermatitis (AD).
Monday, November 04, 2013
New Genetic Mutation Helps Explain Development of Eczema
Researchers found that a mutation in the gene Matt/Tmem79 led to the development of spontaneous dermatitis in mice.
Monday, November 04, 2013
Scientists Solve Structure of Important Protein in Energy Storage of Cells
Scientists at Trinity College Dublin, using a highly specialised crystallography technique have solved a large protein structure that will increase our understanding of energy generation and storage in cells.
Wednesday, July 18, 2012
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial
Daratumumab proved generally safe in patients, even at the highest doses.
Low-level Arsenic Exposure Before Birth Associated with Early Puberty in Female Mice
Study examine whether low-dose arsenic exposure could have similar health outcomes in humans.
Inciting an Immune Attack On Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
‘Mutation-Tracking’ Blood Test for Breast Cancer
Scientists have developed a blood test for breast cancer able to identify which patients will suffer a relapse after treatment, months before tumours are visible on hospital scans.
Cellular Contamination Pathway for Heavy Elements Identified
Berkeley Lab scientists find that an iron-binding protein can transport actinides into cells.
Intensity of Desert Storms May Affect Ocean Phytoplankton
MIT study finds phytoplankton are extremely sensitive to changing levels of desert dust.
Common ‘Heart Attack’ Blood Test May Predict Future Hypertension
Small rises in troponin levels may have value as markers for subclinical heart damage and high blood pressure.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!